DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and ced-3

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001255708.1	Gene:	ced-3 / 178272	WormBaseID:	WBGene00000417	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	311	Identity:	91/311 - (29%)
Similarity:	148/311 - (47%)	Gaps:	56/311 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 HKKDKADATKIAHTPTSELDLKRIIISRPTNEDT-YEN-CARAGIALILNHKDVKGQKQRVGTER 77
            |::|    ......||         |||..:|.| |.| .:..|:.||:|::..:....|.||:.
Worm   213 HEED----MNFVDAPT---------ISRVFDEKTMYRNFSSPRGMCLIINNEHFEQMPTRNGTKA 264

  Fly    78 DRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAREDHSQNDCFVLAVMSHGTEGKVY-AKDMS 141
            |:|::....:..|:.|...|:||...:..|:::.|:.: |..|..:|.::|||.|..:. ..|:.
Worm   265 DKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRDFAKHE-SHGDSAILVILSHGEENVIIGVDDIP 328

  Fly   142 YPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVM-TRELVP----------- 194
            .....:::.....|...|.||||:.|:|||||...:     :.|.|: :.:.||
Worm   329 ISTHEIYDLLNAANAPRLANKPKIVFVQACRGERRD-----NGFPVLDSVDGVPAFLRRGWDNRD 388

  Fly   195 ----------EPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAAN 249
                      .|  .||.:....||.||||:.|:|..::.|:||...||||||::|.|....|
Worm   389 GPLFNFLGCVRP--QVQQVWRKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHA-- 449

  Fly   250 EAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTLTKTF 300
                 :.::::.|||.||:|||..:|:   ::..|.:|:||...|.|.|.|
Worm   450 -----KDMDVVELLTEVNKKVACGFQT---SQGSNILKQMPEMTSRLLKKF 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	80/270 (30%)
ced-3	NP_001255708.1	CARD	2..90	CDD:128424
ced-3	NP_001255708.1	CASc	235..496	CDD:214521	82/276 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162607
Domainoid	1	1.000	130	1.000	Domainoid score	I3239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I3180
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000242
OrthoInspector	1	1.000	-	-		mtm4766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.990