DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Decay and CASP12

DIOPT Version :9

Sequence 1:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001177945.2	Gene:	CASP12 / 100506742	HGNCID:	19004	Length:	341	Species:	Homo sapiens

Alignment Length:	257	Identity:	61/257 - (23%)
Similarity:	110/257 - (42%)	Gaps:	33/257 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LILNHKDVKGQKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKE-VAREDHSQNDCF 122
            |.:.:|:......|.|:|.|...|...|:..|:.|...::||..|:...|:: .|..:|..:|..
Human   101 LNIRNKEFNYLHNRNGSELDLLGMRDLLENLGYSVVIKENLTAQEMETALRQFAAHPEHQSSDST 165

  Fly   123 VLAVMSH-------GTEGKVYAKDMSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAV 180
            .|..|||       ||:......|:.:. :.::..|...||::||:|||:..:||||| |....|
Human   166 FLVFMSHSILNGICGTKHWDQEPDVLHD-DTIFEIFNNRNCQSLKDKPKVIIMQACRG-NGAGIV 228

  Fly   181 EFSS----FAVMTRELVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCR 241
            .|::    .:..|...:.:.......:|.| ....|.:.|.|:.....|:|:..:||.||..:..
Human   229 WFTTDSGKASADTHGRLLQGNICNDAVTKA-HVEKDFIAFKSSTPHNVSWRHETNGSVFISQIIY 292

  Fly   242 VLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNF-MSTLTKTFQL 302
            ...:.:.:..           |..:.:||.:.:      |..|.:.::|.. ..::|:.|.|
Human   293 YFREYSWSHH-----------LEEIFQKVQHSF------ETPNILTQLPTIERLSMTRYFYL 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Decay	NP_477462.1	CASc	54..302	CDD:237997	60/255 (24%)
CASP12	NP_001177945.2	CARD_CASP1-like	6..88	CDD:260036
CASP12	NP_001177945.2	CASc	103..339	CDD:214521	60/255 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152743
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840