DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and Pcdhb19

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_444374.2 Gene:Pcdhb19 / 93890 MGIID:2136757 Length:801 Species:Mus musculus


Alignment Length:1026 Identity:231/1026 - (22%)
Similarity:345/1026 - (33%) Gaps:409/1026 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   783 VEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRR 847
            |||.:.|.::|.|:...|:.:  :||                      |...::.:.|..:||.:
Mouse    36 VEEMLSGALVGNLVKDLGLQV--DEL----------------------SAREAQVASSDNKLPLQ 76

  Fly   848 LVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQ 912
            |    ||                   ..|.||....||||:........::.:...|.:...|.|
Mouse    77 L----NI-------------------NTGDLLLSEPLDREELCGSTEPCVLHFQVLLKNPLKILQ 118

  Fly   913 VNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEF 977
            ..::|.|||||:|.|.....|..|.||..||....:..||   |.|.|.||....::        
Mouse   119 AELQVTDVNDNSPVFLEKEMVLEIPENSPVGAVFLLESAI---DLDVGINAVKSYEI-------- 172

  Fly   978 SIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWN-DEFKYQELHTTFMQTNFKLSSGPYFRISY 1041
                     |:||  |           |::|.:.| |..||.||                     
Mouse   173 ---------SQNS--H-----------FHVTMRVNPDGRKYPEL--------------------- 194

  Fly  1042 TGKRGLDREKQQLYNLKIIAADTGGL---SGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREY 1103
            ...:.||.|:|....|.:.|.| ||.   ||.|.:.|.|.|:|||:|.|:.:             
Mouse   195 VLDKALDYEEQHELRLILTALD-GGTPPRSGTALVRVEVIDINDNSPEFDHM------------- 245

  Fly  1104 TTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKSRRRMVR 1168
                   |.|    :|.|                                               
Mouse   246 -------FYE----VTVP----------------------------------------------- 252

  Fly  1169 ALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQ--GEQVERTPGMPMLRVHGVKYF 1231
                        |::.:|:.::..||.|.|.|.|..:.|...  .|.:.:|             |
Mouse   253 ------------ENSMLGSLLITASAWDLDSGINGEVSYAFSHASEDIRKT-------------F 292

  Fly  1232 AIDKLSGELS----VNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFD 1292
            ||::.|||:.    :::..:.:..|::.  .||..||...:.:|..|||||::.|....|  ||.
Mouse   293 AINEHSGEIRLKGYLDFETTESYSIIIK--ATDRGGLFGKSTVRIQVMDVNDNFPEIIVS--SFI 353

  Fly  1293 TPEGEYKDSVLGQLTAI-DMDFGENANITYTLSDSHLPFTIKPASGV-----LKIGGQLDRELKD 1351
            :|..|.....|..:.:| |.|.|||..:..|:.:. |||.:|  |.:     |:..|.||||...
Mouse   354 SPIPENTAETLVMIFSIRDKDSGENGKMVCTIPEG-LPFVLK--SSIENYYHLETDGALDRESIA 415

  Fly  1352 KYSFQVIATD-NAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVY 1415
            :|:..:..|| ..|   |:::...:.|.|.|||||.|.|    .||.                 |
Mouse   416 EYNITISVTDLGTP---RLTTQHTIIVQVADINDNAPAF----TQTS-----------------Y 456

  Fly  1416 KAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRH-QEMQ---APLFQIDSRDGTISTISRI 1476
            ..:...:..|...:..::|.|.|  ...|..:.||:.. |::|   :.|..|::.:|.:..:..:
Mouse   457 TMFFHENNSPALHIGTISATDSD--AGSNAHITYSLMSAQDLQMALSSLISINADNGQLFALRAL 519

  Fly  1477 NGYNDYEHLNV---SVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYY 1538
                |||.|..   .|.|:|.||||||:.|:|.|                               
Mouse   520 ----DYEVLQAFEFQVGATDRGSPALSSQALVRV------------------------------- 549

  Fly  1539 EVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNMLLYALKPFDRE 1603
             |.|.:|:.||.                                                     
Mouse   550 -VVLDDNDNAPF----------------------------------------------------- 560

  Fly  1604 HISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAPKFRGNGQPIV 1668
                                   |.||:                     :|.:|        |..
Mouse   561 -----------------------VLYPM---------------------QNASA--------PCT 573

  Fly  1669 AVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLL--NEPARLFGIDELSGNI---RLLGELSRTE 1728
            .:||::|..||.||:|.|.|.|.|.||.:.::||  .||. ||.:...:|.:   |||.|....:
Mouse   574 ELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPG-LFSVWAHNGEVRTTRLLSERDAPK 637

  Fly  1729 HIYGFDVKATDRMGADDGRSGIVNVFVYIINEAKQVRL---VVAGMPVEVE 1776
            |.....||.    ..|..||..|.:.|.:::...|..|   .||..|...|
Mouse   638 HRLLLLVKD----NGDPPRSASVTLHVLVVDGFSQPYLPLPEVARNPAHEE 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637
Cadherin_repeat 325..407 CDD:206637
Cadherin_repeat 416..524 CDD:206637
Cadherin_repeat 534..626 CDD:206637
Cadherin_repeat 641..>714 CDD:206637
CA 851..925 CDD:214520 18/73 (25%)
CA 1026..1085 CDD:214520 18/61 (30%)
Cadherin_repeat 1177..1280 CDD:206637 28/108 (26%)
Cadherin_repeat 1289..1385 CDD:206637 33/102 (32%)
Cadherin_repeat 1414..1510 CDD:206637 29/102 (28%)
CA 1576..1658 CDD:214520 4/81 (5%)
Cadherin_repeat 1666..1760 CDD:206637 34/98 (35%)
Pcdhb19NP_444374.2 Cadherin_2 32..112 CDD:285466 24/122 (20%)
Cadherin_repeat 137..238 CDD:206637 41/155 (26%)
Cadherin_repeat 247..343 CDD:206637 31/173 (18%)
Cadherin_repeat 356..447 CDD:206637 30/96 (31%)
Cadherin_repeat 455..557 CDD:206637 32/156 (21%)
Cadherin_repeat 576..664 CDD:206637 33/92 (36%)
Cadherin_C_2 687..769 CDD:293101
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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