DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and Pcdhb16

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_444371.3	Gene:	Pcdhb16 / 93887	MGIID:	2136752	Length:	802	Species:	Mus musculus

Alignment Length:	956	Identity:	205/956 - (21%)
Similarity:	334/956 - (34%)	Gaps:	357/956 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   839 KSKRRLPRRLVGDANIKLRYIIANQQEVV---NKISI---TEDGTLLTLTGLDREQQPSYELTVI 897
            |..|.....||.|..:....:.....:|:   ||:.:   .|.|.||....:|||:...:....:
Mouse    40 KEGRSFVTNLVKDLGLGQLELSRRGAKVISKGNKLHLQLDQETGDLLLNEKVDREKLCGHTEPCL 104

  Fly   898 VEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPN 962
            :.:...|.:...|:|..::|.|:||::|:|.....:..|:|:.:.|....:.:|   ||.|.|.|
Mouse   105 LSFQVLLDNPLDIFQAELEVTDINDHSPEFLDKEIMLKISESSLPGATFPLKNA---QDMDVGQN 166

  Fly   963 AEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQT 1027
            .          .|::.|                 |:...|.:  ||.:.:|..||.||
Mouse   167 G----------IDKYLI-----------------SSNSYFRV--LTRKRSDGKKYPEL------- 195

  Fly  1028 NFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGL--SGYAHLTVLVADVNDNAPMFERI 1090
                          ...|.||||::....|.:.|.|.|.|  ||...:.:.|.|:|||||.||::
Mouse   196 --------------VLDRALDREEEAELRLTLTAQDGGSLPRSGTTEVHIEVLDINDNAPQFEQL 246

  Fly  1091 SVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLG 1155
                                |.::                    .||
Mouse   247 --------------------FYKA--------------------QIP------------------ 253

  Fly  1156 VVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYEL--QGEQVERTP 1218
                                     ||:|:|..::.:||:|:|.|.|..:.|.|  ..:.:.:|
Mouse   254 -------------------------EDSPIGFLIITVSATDKDIGVNGQISYSLFQVSDDISKT- 292

  Fly  1219 GMPMLRVHGVKYFAIDKLSGEL----SVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNN 1279
                        |:|..|:||:    .:::..:.:.||  |:...|.........:...|:|||:
Mouse   293 ------------FSIHPLTGEVRLKEHLDFEKTQSYEI--NIEARDAGTFSGKCTILAQVLDVND 343

  Fly  1280 HAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASG----VLK 1340
            |||....|.::....| ...::::...:..|:|.|||..::.::.|. |||.:|| ||    .|.
Mouse   344 HAPEIILSAFTNSILE-NLPETMVAVFSVSDLDSGENGKVSCSIQDD-LPFFLKP-SGENFYTLL 405

  Fly  1341 IGGQLDRELKDKYSFQVIATD-NAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPS 1404
            ....||||...:|:..:...| .:|:::   :.|::.|.|.|||||.|.|    .||.
Mouse   406 SQKPLDRESVAEYNITITVADMGSPILK---TQVNLTVQVSDINDNAPIF----TQTS------- 456

  Fly  1405 VADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSI----RHQEMQAPLFQIDS 1465
                      |..::..:..|...:..::|.|.|:..|.:  :.||:    .||...|....|::
Mouse   457 ----------YTMFIRENNSPALHIGTISATDSDSGSNAH--ITYSLLPPHDHQLALASFISINA 509

  Fly  1466 RDGTISTISRINGYNDYEHLNV---SVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPP 1527
            .:|.:..:..:    |||.|..   .|.|:|.||||||:.|:|.:
Mouse   510 DNGQLFVLRAL----DYEALQAFEFHVGATDGGSPALSSQALVRM-------------------- 550

  Fly  1528 ANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNM 1592
                        |.|.:|:.||.
Mouse   551 ------------VVLDDNDNAPF------------------------------------------ 561

  Fly  1593 LLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNA 1657
                                              |.||:                     :|.:|
Mouse   562 ----------------------------------VLYPM---------------------QNASA 571

  Fly  1658 PKFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLL--NEPARLFGIDELSGNI-- 1718
                    |...:||::|..||.||:|.|.|.|.|.||.:.::||  .||. ||.:...:|.:
Mouse   572 --------PYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPG-LFSVWAHNGEVHT 627

  Fly  1719 -RLLGELSRTEHIYGFDVKATDRMGADDGRSGIVNVFVYIINEAKQ 1763
             |||.|  |..|.:...:...|  ..|..||..|.:.|.:::...|
Mouse   628 SRLLSE--RDVHKHRLILLVKD--NGDPPRSASVTLHVLLVDGFSQ 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520	18/79 (23%)
		CA	1026..1085	CDD:214520	17/60 (28%)
		Cadherin_repeat	1177..1280	CDD:206637	26/108 (24%)
		Cadherin_repeat	1289..1385	CDD:206637	28/100 (28%)
		Cadherin_repeat	1414..1510	CDD:206637	28/102 (27%)
		CA	1576..1658	CDD:214520	4/81 (5%)
		Cadherin_repeat	1666..1760	CDD:206637	34/98 (35%)
Pcdhb16	NP_444371.3	Cadherin_2	32..113	CDD:285466	16/72 (22%)
		Cadherin_repeat	141..239	CDD:206637	35/150 (23%)
		Cadherin_repeat	248..344	CDD:206637	28/173 (16%)
		Cadherin_repeat	356..448	CDD:206637	28/97 (29%)
		Cadherin_repeat	456..558	CDD:206637	31/156 (20%)
		Cadherin_repeat	572..665	CDD:206637	34/97 (35%)
		Cadherin_C_2	687..770	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000