DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and Pcdhb15

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_444370.1 Gene:Pcdhb15 / 93886 MGIID:2136750 Length:786 Species:Mus musculus


Alignment Length:997 Identity:205/997 - (20%)
Similarity:325/997 - (32%) Gaps:389/997 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   816 SEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLT 880
            :|.|.|...:.:..:.........|.|.  .|:|.|.|  .|:::.:        .:|  |.|:.
Mouse    36 AEETERGTFLANLAKDLGLGLGELSARE--ARIVSDQN--TRFLLLS--------PLT--GELIL 86

  Fly   881 LTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTE 945
            ...||||:........::.:...|.....||:..:.:.|:|||:|.|.....:..|:|:...|..
Mouse    87 NEKLDREELCGPTEPCVLTFQLLLERPFQIYRAALHIKDINDNSPVFLDKEILLKISESTTPGAT 151

  Fly   946 LSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQ 1010
            |.:..|   ||||.|.|:                                               
Mouse   152 LLLERA---QDADVGTNS----------------------------------------------- 166

  Fly  1011 WNDEFKYQELHTTFMQTNFKLSSGPYFRIS-YTGKRG-----------LDREKQQLYNLKIIAAD 1063
                           .:|:.:|...||.|. :.|..|           ||||:...:.|.:.|.|
Mouse   167 ---------------LSNYTISPNDYFHIHVHDGGEGPIIPELVLDKMLDREEIPEFTLTLTALD 216

  Fly  1064 TGG--LSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAA 1126
            .|.  .||.|.:.:||.|:|||:|.|.:                  .:|.|:|.           
Mouse   217 GGSPPRSGTALVQILVLDINDNSPQFVQ------------------SLYKVQSP----------- 252

  Fly  1127 MMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQ 1191
                                                                  |:||||:.|:.
Mouse   253 ------------------------------------------------------ENTPVGSLVVA 263

  Fly  1192 LSASDEDFGKNALLHYEL--QGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIML 1254
            :||.|.|.|....:.|..  ..|::.:|             |.|:..||||.:...|  |.|.:.
Mouse   264 VSARDLDTGSYGQIDYTFFYATERILQT-------------FQINSTSGELYLKREL--NYEAIQ 313

  Fly  1255 NLTVT----DIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGE 1315
            ..::|    |..||.....:...|||||::.|.|..|..:...||.. :::|:......|.|.|.
Mouse   314 TYSITIQARDGGGLSGKCAVVVEVMDVNDNPPEFLLSSLNSPIPENS-QETVVAVFKIRDRDSGN 377

  Fly  1316 NANITYTLSDSHLPFTIKPASG---VLKIGGQLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEV 1377
            |.....::::. |||.:||:..   .|.....||||...:|:..:..||..  :.|:::...:.|
Mouse   378 NGKTLCSIAND-LPFVLKPSVENFYTLVTEKPLDRESNTEYNITITVTDMG--IPRLTTQHTITV 439

  Fly  1378 NVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGN 1442
            .|.|||||.|.|    .||.                 |..::..:..|...:..::|.|.|:..|
Mouse   440 QVSDINDNAPTF----TQTS-----------------YTMFVRENNSPALHIGTISATDSDSGSN 483

  Fly  1443 GNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIVIV 1507
            .:  :.||:|                             ..|           .|.|:..:::.:
Mouse   484 AH--ITYSLR-----------------------------LPH-----------DPQLALDSLISI 506

  Fly  1508 NLQGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWL 1572
            |                                                                
Mouse   507 N---------------------------------------------------------------- 507

  Fly  1573 EEGLDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIE 1637
                            |.|..|:||:..|.|.:..::..:.|                 :|:...
Mouse   508 ----------------ADNGQLFALRALDYEALQAFEFHVGA-----------------IDQGSP 539

  Fly  1638 GLSLNECRILVHIADENDNAP----KFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIR 1698
            .|| ::..:.|.|.|:|||||    ..:....|...:||::|..||.||:|.|.|.|.|.||.:.
Mouse   540 ALS-SQALVRVVILDDNDNAPFVLYPMQNASAPYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLS 603

  Fly  1699 YRLL--NEPARLFGIDELSGNI---RLLGELSRTEHIYGFDVKATDRMGADDG---RSGIVNVFV 1755
            ::||  .||. ||.:...:|.:   |||.|....:|.....||       |:|   ||..|.:.|
Mouse   604 FQLLKATEPG-LFSVWAHNGEVRTTRLLSERDVPKHKLLVVVK-------DNGEPPRSASVTLHV 660

  Fly  1756 YIINEAKQVRLVVAGMPVEVER 1777
            .:::...|..|::.    ||.|
Mouse   661 LLVDGFSQPFLILP----EVAR 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637
Cadherin_repeat 325..407 CDD:206637
Cadherin_repeat 416..524 CDD:206637
Cadherin_repeat 534..626 CDD:206637
Cadherin_repeat 641..>714 CDD:206637
CA 851..925 CDD:214520 17/73 (23%)
CA 1026..1085 CDD:214520 24/72 (33%)
Cadherin_repeat 1177..1280 CDD:206637 32/108 (30%)
Cadherin_repeat 1289..1385 CDD:206637 26/98 (27%)
Cadherin_repeat 1414..1510 CDD:206637 13/95 (14%)
CA 1576..1658 CDD:214520 17/81 (21%)
Cadherin_repeat 1666..1760 CDD:206637 35/101 (35%)
Pcdhb15NP_444370.1 Cadherin_2 30..111 CDD:285466 17/88 (19%)
Cadherin_repeat 140..238 CDD:206637 33/162 (20%)
Cadherin_repeat 247..343 CDD:206637 35/175 (20%)
Cadherin_repeat 356..447 CDD:206637 26/94 (28%)
Cadherin_repeat 455..557 CDD:206637 28/258 (11%)
Cadherin_repeat 571..664 CDD:206637 35/100 (35%)
Cadherin_C_2 686..769 CDD:293101
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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