DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and Pcdhb13

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_444368.1	Gene:	Pcdhb13 / 93884	MGIID:	2136748	Length:	796	Species:	Mus musculus

Alignment Length:	939	Identity:	199/939 - (21%)
Similarity:	318/939 - (33%)	Gaps:	355/939 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   873 TEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLIN 937
            |:|  |:....||||:........::.:...|.:....||..::|.|:||:||:|.|...:..|:
Mouse    80 TQD--LMLNENLDREELCGSTEPCVLSFRVLLKNPLQFYQAELRVIDINDHAPEFPAREMLLKIS 142

  Fly   938 ENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAF 1002
            |....|....:..|   ||.|.|.:               ||:  :.|.|:|...|.
Mouse   143 EIAPPGKIFPLKMA---QDLDTGSH---------------SIQ--SYTVSDNPHFHV-------- 179

  Fly  1003 NIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGG- 1066
                ||...:|..|:.||                     ...:.||||||....||:.|.|.|.
Mouse   180 ----LTRNRSDGKKFPEL---------------------VLDKALDREKQDQLRLKLTAVDGGSP 219

  Fly  1067 -LSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLA 1130
             .||...:.:||.|:|||.|.|.:                  |:|.|:
Mouse   220 PRSGTTEIQILVLDINDNTPEFAQ------------------ELYEVQ----------------- 249

  Fly  1131 PPPYHIPGSPRFNVDRERSVGAGLGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSAS 1195
                 :|                                           |::|:|:.::.:||.
Mouse   250 -----VP-------------------------------------------ENSPIGSLLITVSAR 266

  Fly  1196 DEDFGKNALLHYELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTD 1260
            |.|.|....:.|.|..:.....|            |.|:..:||:.:...|........::.|..
Mouse   267 DLDAGPFGEVSYGLSQDDDVNEP------------FEINTKTGEIRLKSTLDFEAFQSYHVDVEA 319

  Fly  1261 ID--GLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAI----DMDFGENANI 1319
            :|  ||.....|...|:|||::||....|..:...||     ::.|.:.|:    |.|.|.|..:
Mouse   320 LDGGGLTGKCSLVVQVLDVNDNAPEVILSSLNSPIPE-----NLPGIIVAVFSVSDADSGNNQQV 379

  Fly  1320 TYTLSDSHLPFTIKPASG---VLKIGGQLDRELKDKYSFQVIATD-NAPVMQRMSSSVDVEVNVL 1380
            ..:: |.:|||.::|:..   .|:..|.||||.:.:|:..:..|| ..|   |:::..::.|.|.
Mouse   380 MCSI-DDNLPFLLRPSMENFYTLETDGALDRESRSEYNITITVTDMGTP---RLTTQHNITVQVS 440

  Fly  1381 DINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNG 1445
            |||||.|.|    .||.                 |..::..:..|...:..::|.|.|:..|.:
Mouse   441 DINDNAPAF----TQTS-----------------YTLFVHENNSPALHIGTISATDSDSGSNAH- 483

  Fly  1446 LVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQ 1510
             :.||:        |...|.:                                |:.|::|.:|
Mouse   484 -ITYSL--------LLPQDKQ--------------------------------LTLTSLVSIN-- 505

  Fly  1511 GQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEG 1575

Mouse   506 ----------------------------------------------------------------- 505

  Fly  1576 LDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLS 1640
                         |.|..|:||:..|.|.:..::.|:.|                 .|:....||
Mouse   506 -------------ADNGQLFALRALDYEALQAFEFRVDA-----------------TDQGSPALS 540

  Fly  1641 LNECRILVHIADENDNAP----KFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRL 1701
             ::..:.|.:.|:|||||    ..:....|...:||::|..||.||:|.|.|.|.|.||.:.::|
Mouse   541 -SQVLVRVVVLDDNDNAPFVLYPMQNASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQL 604

  Fly  1702 L--NEPARLFGIDELSGNI---RLLGELSRTEHIYGFDVKATDRMGADDG---RSGIVNVFVYII 1758
            .  .||. ||.:...:|.:   |||.|....:|.....||       |:|   ||..|.:.|.::
Mouse   605 FKATEPG-LFSVWAHNGEVRTTRLLSERDVPKHRLLLLVK-------DNGEPPRSASVTLHVLLV 661

  Fly  1759 NEAKQVRLVVAGMPVEVERRIEGLMEALS 1787
            :...|..|   .:|...:...|...:||:
Mouse   662 DGFSQPYL---PLPEVAQDSTEDAEDALT 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520	14/51 (27%)
		CA	1026..1085	CDD:214520	19/60 (32%)
		Cadherin_repeat	1177..1280	CDD:206637	25/104 (24%)
		Cadherin_repeat	1289..1385	CDD:206637	29/103 (28%)
		Cadherin_repeat	1414..1510	CDD:206637	14/95 (15%)
		CA	1576..1658	CDD:214520	17/81 (21%)
		Cadherin_repeat	1666..1760	CDD:206637	34/101 (34%)
Pcdhb13	NP_444368.1	Cadherin_2	30..111	CDD:285466	8/32 (25%)
		Cadherin_repeat	139..237	CDD:206637	37/150 (25%)
		Cadherin_repeat	246..341	CDD:206637	28/171 (16%)
		Cadherin_repeat	354..445	CDD:206637	29/99 (29%)
		Cadherin_repeat	453..555	CDD:206637	29/258 (11%)
		Cadherin_repeat	574..662	CDD:206637	33/95 (35%)
		Cadherin_C_2	686..765	CDD:293101	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000