DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and Cdhr1

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_446024.1	Gene:	Cdhr1 / 93662	RGDID:	620420	Length:	859	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	213/906 - (23%)
Similarity:	350/906 - (38%)	Gaps:	208/906 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VFGLIAIGQAAKTGQVQASSGSCAFHTLD-GVAAESEGVRFIRLREDAQVGKEILRLQAYPRSTA 99
            |.||:.|         ..:..:.|.|..| ||.:.:..:....|.||..||..:.
  Rat    10 VLGLLCI---------YLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVY---------- 55

  Fly   100 ALKGADASGDHKYFNLTEHNATTLVVSLARSLERL-----VDRDVPRNLLKFRILCAGKQEKLE- 158
            .|.|.|..||...::::...:|..|.|:..:...:     :||:              :::::|
  Rat    56 TLNGTDPEGDPISYHISFDPSTRSVFSVDPNFGNITLVEELDRE--------------REDEIEA 106

  Fly   159 -----EGSYL---SITVYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNS 215
                 :|..|   .:.:.:.|.||.||.||..||.:.|.|||...|.||: |||.|:| ..:..|
  Rat   107 IISISDGLNLVAEKVVIVVTDANDEAPRFLQEPYNILVPENTPAGSSIFK-VQAEDKD-TGSGGS 169

  Fly   216 EVHFSMSTVPEQLSADGSPYFALKSPHRPLLILK--RELDFDNGIRQFKLPIFAWDRGTPAN--- 275
            ..:|..|....:.:.|         .|..:|.|:  ..||::.....| :.:.|.|.|....
  Rat   170 VTYFLQSLHSSKFTVD---------RHSGVLRLQAGATLDYEKSRAHF-ITVVAKDGGGRLRGAD 224

  Fly   276 ---QANTTITINVRDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQDSLNAS- 336
               .|.||:||||.||.|..|.|....|...:.|        ..:|......::|.|.|....:
  Rat   225 VVFSATTTVTINVEDVQDTAPIFVGTPYYGYVYE--------DTLPGSEVLTVVAIDGDRGKPNH 281

  Fly   337 LVYDIISGNERQLFRVNPHNG-VMYLQKEIDLEEESLPGNTFVLQL-----EARQKDNPLKKALA 395
            ::|.:::.:: .||.:|..:| :..||....|..|       |.:|     |.....:|..::..
  Rat   282 ILYRLLNESD-GLFEINETSGAISVLQSPAQLRRE-------VYELHVQVTEVNSSGSPAAQSTV 338

  Fly   396 RIEVEVLDLNDNVPEFEAD-----YYNISIVENLPTG--FSVLQVNAVDRDQGENSEFLYNLVET 453
            .:.:.::|||::.|.|..:     .:.:|:.|:.|.|  ...|::...|.|||.|::|...||
  Rat   339 PVIIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVNDSDQGANAKFNLRLV-- 401

  Fly   454 KDAAGAFRIDSRT------GWITVRDDRLLDREQRRSIQLNVEALERN-PSYLDDKHLKKPGPSK 511
             ...|.||:..:|      ..|.|.:...:|.|:.:|:...:.|:|.| |....         |.
  Rat   402 -GPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKSLTFKLLAIEVNTPEKFS---------ST 456

  Fly   512 VQVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGY 576
            ..:.|.|||||||.|||. .:.|..::|.|.|.|..:..|.|.|||.||.|.:.|.:.   |:|.
  Rat   457 ADIVIQLLDTNDNVPKFT-SHYYIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIY---GTGS 517

  Fly   577 IPFRLDNKNGTIYV---------GGPLRRGRIAVFVEATDQPTNPSERRFSLAVITIEVYAT--- 629
            ..|.:....|.||.         |    ..|...:|:|.|.     :.|:|||    ||:.|
  Rat   518 DLFLIHPSTGLIYTQPWASLDAEG----TSRYNFYVKAEDM-----DGRYSLA----EVFVTLLD 569

  Fly   630 IDDQAIDFVGAPYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGV-PFAIEERSGI 693
            ::|....||.:..|..:...|||     ::..|.........:.|...|.:|.| .|.|:..:|.
  Rat   570 VNDHYPQFVQSVQEKTMVLGTPL-----KIEATDQDAEEPNNLVDYSITRAEPVNVFDIDAHTGE 629

  Fly   694 ITVIRELSEFKRKVYQFEAVANYL----FANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLT 754
            |       ..|..:...||:.|..    ::.|.|.....|.|...:|.|.             |.
  Rat   630 I-------RLKNSIRSLEALHNITPSGEYSWSLQVQAKDRGSPSFSTTAL-------------LK 674

  Fly   755 IHIVNKPEQKVPLRPVIEEINMNVIHFHVEEN---VVGGIIGQLLYKNGINLVNNELGTYREMPS 816
            |.|.:...        :...:|.......::|   .||.:.|.:.....|.::
  Rat   675 IDITDTER--------LSRSSMAAFLIQTKDNPMKAVGVLAGVMAIVVAITVL------------ 719

  Fly   817 EPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDA--NIKLRYIIANQQEVVNKISITED 875
                  |:..:.:|:: :|......||:.||....|  .:::.::...:.:..:|..:.||
  Rat   720 ------ISTATFWRNK-KSNKVLPVRRVLRRRPSPAPHTVRIEWLKFRRAKAASKFILKED 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	36/114 (32%)
		Cadherin_repeat	325..407	CDD:206637	19/88 (22%)
		Cadherin_repeat	416..524	CDD:206637	33/116 (28%)
		Cadherin_repeat	534..626	CDD:206637	29/100 (29%)
		Cadherin_repeat	641..>714	CDD:206637	16/73 (22%)
		CA	851..925	CDD:214520	4/27 (15%)
		CA	1026..1085	CDD:214520
		Cadherin_repeat	1177..1280	CDD:206637
		Cadherin_repeat	1289..1385	CDD:206637
		Cadherin_repeat	1414..1510	CDD:206637
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
Cdhr1	NP_446024.1	Cadherin_repeat	42..130	CDD:206637	19/111 (17%)
		Cadherin_repeat	139..242	CDD:206637	36/114 (32%)
		Cadherin_repeat	251..350	CDD:206637	22/114 (19%)
		Cadherin_repeat	364..469	CDD:206637	33/116 (28%)
		Cadherin_repeat	478..573	CDD:206637	32/110 (29%)
		Cadherin_repeat	580..679	CDD:206637	26/123 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..859
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910