DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and DCHS1

DIOPT Version :10

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_003728.1 Gene:DCHS1 / 8642 HGNCID:13681 Length:3298 Species:Homo sapiens


Alignment Length:2004 Identity:480/2004 - (23%)
Similarity:746/2004 - (37%) Gaps:540/2004 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 EDAQVGKEILRLQAY-PRS-----TAALKGADASGDHKYFNLTEHNATTLVVSLARSLERLVDRD 138
            ||...|..:..:||: |..     |.:|.|.|..|   .|:|      ..|..|.::| |.:||:
Human   801 EDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRG---LFSL------DAVSGLLQTL-RPLDRE 855

  Fly   139 VPRNLLKFRILCAGKQEKLEEGS-------YLSITVYIEDVNDNAPEFLNVPYVVDVDENTSIES 196
            :...:|:..:         ..||       ...:.|.::|||||:|.|......|.:..||:..:
Human   856 LLGPVLELEV---------RAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGT 911

  Fly   197 IIFEGVQAFDRDKPNTPNSEVHFSMSTVPEQLSADGSPYFALKSPHRPLLILKRELDFDNGIRQF 261
            .|:. ::|.|.|  :..||.|.|:       |.|.|...|.: .|....:.|.|.|. .:|....
Human   912 PIYT-LRALDPD--SGVNSRVTFT-------LLAGGGGAFTV-DPTTGHVRLMRPLG-PSGGPAH 964

  Fly   262 KLPIFAWDRGTPANQANTTITINVRDVD--DLPPKFTEGVYRTRINEFYP---MTGVPIRIPLYF 321
            :|.:.|.|.|:|...::..:.:.|:||.  .|.|:|....||..:    |   ..|..:......
Human   965 ELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDL----PSGTTAGTQVLQVQAQ 1025

  Fly   322 APPIMAFDQDSLNASLVYDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEA--- 383
            ||.         ...:.|.:.:......|.:.|.:|.::::..:|.|.:.|    ::|::.|   
Human  1026 APD---------GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQEL----YILKVMAVSG 1077

  Fly   384 RQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFLY 448
            .:.:...:...|.:.|.:|:.|::.|....|...:::.||.|.|.||.:|.|.|||.|.|....|
Human  1078 SKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTY 1142

  Fly   449 NLVETKDAAGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQ 513
            :|.:..:.:.||||..:||.:|..  :.|||||:.|.||.|:..:..         ..|..:...
Human  1143 SLQQLSEDSKAFRIHPQTGEVTTL--QTLDREQQSSYQLLVQVQDGG---------SPPRSTTGT 1196

  Fly   514 VEITLLDTNDNTPKF-----EHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKG 573
            |.:.:||.|||:|.|     ..|.....:||...|.|.::..:.|.|||||.||.:||.|   .|
Human  1197 VHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL---TG 1258

  Fly   574 SGYIPFRLDNKNGTIYVGGPL---RRGRIAVFVEATDQPTNPSERRFSLAV-------------- 621
            .|...|.|...:|.:....||   .|....:.:.|.||.:.|......|.|              
Human  1259 PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPD 1323

  Fly   622 -----------ITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDL 675
                       :.:.|.|....:....:|:     |.|..|.|  ||.:..||:  ||.:     
Human  1324 LAERDPAAPVPVVLTVTAAEGLRPGSLLGS-----VAAPEPAG--VGALTYTLV--GGAD----- 1374

  Fly   676 LHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQSLVMSRSSSPLTTIASP 740
                .||. ||::..||.:.:.|.|        .|||...:      ::|.: |:..|       
Human  1375 ----PEGT-FALDAASGRLYLARPL--------DFEAGPPW------RALTV-RAEGP------- 1412

  Fly   741 AELSDEGVLITNLTIHIVNKPEQ-----KVPLRPVIEEINMNVIHFHVEENVVGGIIGQLLYKNG 800
               ...|..:..:.:.:.::.|.     :.||...:.|        :.|.       |..||   
Human  1413 ---GGAGARLLRVQVQVQDENEHAPAFARDPLALALPE--------NPEP-------GAALY--- 1456

  Fly   801 INLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRYIIANQQE 865
                     |:|...::...                               .|..:||.:..|:.
Human  1457 ---------TFRASDADGPG-------------------------------PNSDVRYRLLRQEP 1481

  Fly   866 VVNKISI-TEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSG----AGIYQVNIKVDDVNDNAP 925
            .|..:.: ...|.|....|||||..|:  |.::||.:....:.    |......:.|.|.|||||
Human  1482 PVPALRLDARTGALSAPRGLDRETTPA--LLLLVEATDRPANASRRRAARVSARVFVTDENDNAP 1544

  Fly   926 KFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENS 990
            .|                  .|.:...|.:|...||.|...|....|..:...:.|  ..:|...
Human  1545 VF------------------ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSY--RLASGGD 1589

  Fly   991 THHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLY 1055
            .|.::.|:|||.::.                                       |.||||::..:
Human  1590 GHFRLHSSTGALSVV---------------------------------------RPLDREQRAEH 1615

  Fly  1056 NLKIIAADTGG--LSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVESSSGM 1118
            .|.::|:|.|.  .|....|||.||||||.||.|::           :||:    :...|::   
Human  1616 VLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ-----------QEYS----VLLRENN--- 1662

  Fly  1119 TAPQATAAMML-APPP---------YHIPGSPRFN-------------VDRERSVGAGLGVVARA 1160
              |..|:.:.| |..|         |....|..|:             :|||......|.|.|:.
Human  1663 --PPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQD 1725

  Fly  1161 KSRRRMVRALTTK---------CPLFA---IYEDTPVG---TKVLQLSASDEDFGKNALLHYELQ 1210
            :.....:..:|.:         .|.|.   :..:.|.|   ..:..|.|||.|.|.|..|.|.: 
Human  1726 RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRI- 1789

  Fly  1211 GEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDG----LKDSTCLR 1271
                  ..|.|    .|.  |.:|..|||.....||...:|....|.:...||    |..:..|.
Human  1790 ------LDGDP----SGA--FVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLT 1842

  Fly  1272 FTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTL-SDSHLPFTIKPA 1335
            .||:|.|:|||.|....||.:.||.....::|.||.|.|.|.|.|.::||.| :.:...|.::|:
Human  1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPS 1907

  Fly  1336 SGVLKIGGQLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVK 1400
            ||.|:....||||....|:|.|.|.|.| ....:|::|.|.:.|.|:||:.|.|.....:.:..:
Human  1908 SGELRTAAALDREQCPSYTFSVSAVDGA-AAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971

  Fly  1401 FIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDS 1465
            ..||.:..||.|...:|                   :|.....|..:||  |......|...:||
Human  1972 PGPSFSTPTLALATLRA-------------------EDRDAGANASILY--RLAGTPPPGTTVDS 2015

  Fly  1466 RDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPPANV 1530
            ..|.|............:.: :.::|:|:|.||.|||.::||.|||:|...|.            
Human  2016 YTGEIRVARSPVALGPRDRV-LFIVATDLGRPARSATGVIIVGLQGEAERGPR------------ 2067

  Fly  1531 TVFQHAYYEVKLTENNE--APIEVMRLNLSAGLN-PENYRWSLWLEEGLDETDAHPPFEYDAKNM 1592
              |..|..|..:.||..  .||...|...:.|.| |..|......|:|                 
Human  2068 --FPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKG----------------- 2113

  Fly  1593 LLYALKPFDREHISRYQLRIRAD-----------RLSREARNYARVSYPVVDERIEGLSLNECRI 1646
             .::::|      |...:.:|:.           ||..:|.:....::.|              :
Human  2114 -TFSIQP------STGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV--------------L 2157

  Fly  1647 LVHIADENDNAPKFRGNGQP-IVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRL-LNEPAR-L 1708
            .:.:.|.|||||:|.   :| .||.||:|.....|:.:|||:|||:|...:|.|.| .::||| |
Human  2158 TLTLQDANDNAPRFL---RPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL 2219

  Fly  1709 FGIDELSGNIRLLGELSRTEHIYGFDVKATDR---MGADDGRSGIV-----NVFVYIINEAKQVR 1765
            |.:|..:|.|.....|.|       ::.|..|   |..|.|...:|     .|.|...|:.:.. 
Human  2220 FHVDPTTGTITTTAILDR-------EIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPT- 2276

  Fly  1766 LVVAGMPVEVERRIEG---LMEALSDAIGKDVRV-----RLLEPYSGGLEPATNAYIYAVDPHTN 1822
                 :|...|.|:..   |...::...|.||..     .:|.| ||..:|      ::|..:..
Human  2277 -----IPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSP-SGPQDP------FSVGRYGG 2329

  Fly  1823 SIMEMEQLQDALAGLQLDALQLQQQKLDG---GKPMPRILELAEFGQLARPAHASASSFMGGLEF 1884
            .:    .|...|...|.|..|||....||   |:        |....|....:.:|.:|...|  
Human  2330 RV----SLTGPLDFEQCDRYQLQLLAHDGPHEGR--------ANLTVLVEDVNDNAPAFSQSL-- 2380

  Fly  1885 VTVVLL-------ALISLGALIAACCYVCMRQKRRLWSQRDFSASDAGLTYTIA 1931
            ..|:||       |::|:.|                 :.|| |.::..::|.:|
Human  2381 YQVMLLEHTPPGSAILSVSA-----------------TDRD-SGANGHISYHLA 2416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 28/108 (26%)
Cadherin_repeat 325..407 CDD:206637 13/84 (15%)
Cadherin_repeat 416..524 CDD:206637 36/107 (34%)
Cadherin_repeat 534..626 CDD:206637 29/119 (24%)
Cadherin_repeat 641..>714 CDD:206637 21/72 (29%)
CA 851..925 CDD:214520 22/78 (28%)
CA 1026..1085 CDD:214520 19/60 (32%)
Cadherin_repeat 1177..1280 CDD:206637 32/112 (29%)
Cadherin_repeat 1289..1385 CDD:206637 36/96 (38%)
Cadherin_repeat 1414..1510 CDD:206637 21/95 (22%)
CA 1576..1658 CDD:214520 11/92 (12%)
Cadherin_repeat 1666..1760 CDD:206637 35/104 (34%)
DCHS1NP_003728.1 Cadherin_repeat 49..139 CDD:206637
Cadherin_repeat 150..251 CDD:206637
Cadherin_repeat 260..358 CDD:206637
Cadherin_repeat 374..468 CDD:206637
Cadherin_repeat 482..574 CDD:206637
Cadherin_repeat 583..681 CDD:206637
Cadherin_repeat 689..781 CDD:206637
Cadherin_repeat 794..890 CDD:206637 26/107 (24%)
Cadherin_repeat 900..991 CDD:206637 26/102 (25%)
Cadherin_repeat 1004..1101 CDD:206637 19/113 (17%)
Cadherin_repeat 1114..1207 CDD:206637 36/103 (35%)
Cadherin_repeat 1224..1312 CDD:206637 29/90 (32%)
Cadherin_repeat 1336..1432 CDD:206637 28/139 (20%)
Cadherin_repeat 1445..1542 CDD:206637 27/156 (17%)
Cadherin_repeat 1551..1644 CDD:206637 31/133 (23%)
Cadherin_repeat 1653..1747 CDD:206637 18/102 (18%)
Cadherin_repeat 1757..1851 CDD:206637 31/106 (29%)
Cadherin_repeat 1860..1956 CDD:206637 36/96 (38%)
Cadherin_repeat 1983..2056 CDD:206637 20/94 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2065..2094 9/42 (21%)
Cadherin_repeat 2074..2167 CDD:206637 21/130 (16%)
Cadherin_repeat 2175..2273 CDD:206637 35/104 (34%)
Cadherin_repeat 2282..2372 CDD:206637 24/108 (22%)
Cadherin_repeat 2381..2478 CDD:206637 11/54 (20%)
Cadherin_repeat 2486..2598 CDD:206637
Cadherin_repeat 2606..2702 CDD:206637
Cadherin_repeat 2712..2808 CDD:206637
Cadherin_repeat 2818..2923 CDD:206637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2986..3040
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3062..3082
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3233..3298
Blue background indicates that the domain is not in the aligned region.

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