DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and PCDH11Y

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_116755.1 Gene:PCDH11Y / 83259 HGNCID:15813 Length:1340 Species:Homo sapiens


Alignment Length:1063 Identity:247/1063 - (23%)
Similarity:384/1063 - (36%) Gaps:337/1063 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   716 YLFANSSQSLVMSRSSSPL---------TTIASPAELSDE---GVLITNLTIHIVNKPEQKVPLR 768
            :|..:||.||      |||         ||......||..   .||:..:..| ....|:...:|
Human     6 FLIISSSSSL------SPLLLVSVVRVNTTNCHKCLLSGTYIFAVLLVCVVFH-SGAQEKNYTIR 63

  Fly   769 PVIEEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGT--------YR--EMP----SEPT 819
               |||..||            :||.||....::|:.|:..|        |:  ::|    .|.|
Human    64 ---EEIPENV------------LIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDT 113

  Fly   820 SRNITMGSRFRSRNRSRSSKSKRRLPR------------------RLVGDANIKLRYIIANQQE- 865
            ....|.|:|.   :|.:....   :||                  |||     |:|::|.:..: 
Human   114 GEIFTTGARI---DREKLCAG---IPRDEHCFYEVEVAILPDEIFRLV-----KIRFLIEDINDN 167

  Fly   866 -------VVNKISITEDGT---------------------------------------------- 877
                   |:| |||.|:..                                              
Human   168 APLFPATVIN-ISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMP 231

  Fly   878 -LLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCV 941
             |:....||||::.:|.:.|.|| ..|....:....:.:.|.|.|||.|.|........|.||..
Human   232 QLIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAP 295

  Fly   942 VGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFN 1006
            |||.::..||   .|||.|.||:.          .||...:....:....|  :.:|||...|  
Human   296 VGTSVTQLHA---TDADIGENAKI----------HFSFSNLVSNIARRLFH--LNATTGLITI-- 343

  Fly  1007 LTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYA 1071
                                                 |..||||:...:.|.::|:|.|.:...|
Human   344 -------------------------------------KEPLDREETPNHKLLVLASDGGLMPARA 371

  Fly  1072 HLTVLVADVNDNAPMFE--------------------------------------RISVFKDSRL 1098
            .:.|.|.|||||.|..:                                      |::.|.|..:
Human   372 MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 436

  Fly  1099 EIREYTTDMEIYFVESSSGM--TAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAK 1161
            ..|........:.:|:::.:  .:.:..|..:||..    .|.|..|        ....:..:.|
Human   437 PFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD----AGKPPLN--------QSAMLFIKVK 489

  Fly  1162 SRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPMLRVH 1226
            .........|......:|.|:...|.:::::||:|.|.|.||.::|.|       .|..|     
Human   490 DENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLL-------GPDAP----- 542

  Fly  1227 GVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDG----LKDSTCLRFTVMDVNNHAPTFKKS 1287
              ..|::|:.:|.|:|...|....|.....|:...|.    |..:..:..:::|.|:::|.|..:
Human   543 --PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 605

  Fly  1288 WYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDK 1352
            .|.|..||...:...:|.:|..|.|:|:|:.:|.::.|.:..|||...:||::.....|||.::.
Human   606 EYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQES 670

  Fly  1353 YSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFI------GYDDQTKAVKFIPSVADRTLM 1411
            |:|.|.|.|...|.:  |||..|.:||:|:|||:|.||      .|:                |:
Human   671 YTFYVKAEDGGRVSR--SSSAKVTINVVDVNDNKPVFIVPPYNYSYE----------------LV 717

  Fly  1412 LPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRI 1476
            ||        ||.|||.|.|:.|:|.|.  ..|..|.|||.....: .||.||...|.|:.:.:.
Human   718 LP--------STNPGTVVFQVIAVDNDT--GMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKC 771

  Fly  1477 NGYNDYEHLNVSVIASDVGSPALSATAIVIVNL-QGQAVTDPP-------KSTPKPEPPAN---- 1529
            : ..|.....|.|.|:|:|.|. |..::||||| ..::||:..       ||...|..|..    
Human   772 D-VTDLGLHRVLVKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIAD 834

  Fly  1530 -----------------------VTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLW 1571
                                   |.:|..|....:...:.:|..:.|:.:..|..||||.:..:.
Human   835 VSSPTSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNMQNSEWATPNPENRQMIMM 899

  Fly  1572 LEEGLDETDAHPPFEYDAKNMLL 1594
            .::  .:...|.|     ||:||
Human   900 KKK--KKKKKHSP-----KNLLL 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637
Cadherin_repeat 325..407 CDD:206637
Cadherin_repeat 416..524 CDD:206637
Cadherin_repeat 534..626 CDD:206637
Cadherin_repeat 641..>714 CDD:206637
CA 851..925 CDD:214520 24/128 (19%)
CA 1026..1085 CDD:214520 17/58 (29%)
Cadherin_repeat 1177..1280 CDD:206637 26/106 (25%)
Cadherin_repeat 1289..1385 CDD:206637 34/95 (36%)
Cadherin_repeat 1414..1510 CDD:206637 34/96 (35%)
CA 1576..1658 CDD:214520 6/19 (32%)
Cadherin_repeat 1666..1760 CDD:206637
PCDH11YNP_116755.1 E_set 60..134 CDD:298831 21/94 (22%)
Cadherin_repeat 175..277 CDD:206637 19/103 (18%)
Cadherin_repeat 285..383 CDD:206637 36/151 (24%)
CA 416..496 CDD:214520 12/91 (13%)
Cadherin_repeat 504..598 CDD:206637 26/107 (24%)
Cadherin_repeat 606..701 CDD:206637 34/96 (35%)
Cadherin_repeat 713..804 CDD:206637 38/119 (32%)
Protocadherin 807..1008 CDD:285562 22/116 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1112
FAM75 <1164..>1270 CDD:291323
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1321..1340
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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