Protein Alignment Cad89D and PCDH15

DIOPT Version :10

• Sequence 1: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Sequence 2: NP_001136235.1
• Gene: PCDH15 / 65217
• HGNCID: 14674
• Length: 1962
• Species: Homo sapiens
• Alignment Length: 2307
• Identity: 480/2307 - (20%)
• Similarity: 771/2307 - (33%)
• Gaps: 859/2307 - (37%)

  Fly   130 SLERLVDRDVPRNL--LKFRILCAGKQEKLEEGSYLSITVYIEDVNDNAPEFLNVPYVVDVDENT 192
            |..|::|||.|.|:  :..::.|..|  |:....|..:.:.:.|.|||:|.|.:..|...|:|.|
Human   103 STGRVLDRDPPMNIHSIVVQVQCINK--KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELT 165

  Fly   193 SIESIIFEGVQAFDRDKPNT-----PNSEVHFSMSTVPEQLSADGSPYFALKSPHRPL-----LI 247
            .:.:.||.|   |..|...|     ||.::.:.:...|:..:::.:  |.:     ||     ::
Human   166 PVGTTIFTG---FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDT--FEI-----PLMLTGNIV 220

  Fly   248 LKRELDFDNGIRQFKLPIFAWDRGTPANQ---ANTTITINVRDVDDLPPKFTEGVYRTRINEFYP 309
            |::.|::::..|.|.: |.|.||....|:   ..||:|::|.|.|||.|.|...|......:..|
Human   221 LRKRLNYEDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 284

  Fly   310 MT---GVP-IRI-----PLYFAPPIMAFDQD------SLNASLVYDIISGNER---QLFRVNPHN 356
            :|   .:| :|.     |:...|||.|.|||      |....::|.|:.|...   :.|.::|..
Human   285 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRT 349

  Fly   357 GVMYLQKEI--DLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNIS 419
            ..:.|.:.:  |..::      |.|.::|.|.:.....|.|.:.:|:||.|:..|.|....|...
Human   350 AELSLLEPVNRDFHQK------FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGY 408

  Fly   420 IVENLPTGFSV---------LQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRTGWITVRDDR 475
            |:|:.|.|.::         |::.|:|:|          :.:|||......::..|...||....
Human   409 ILESAPVGATISDSLNLTSPLRIVALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTG 463

  Fly   476 L---------LDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLDTNDNTPKFEHG 531
            :         :|||::::...::.|       .|.....:|    |.|.|.::|.|||||.|...
Human   464 ITRYLTLLQPVDREEQQTYTFSITA-------FDGVQESEP----VIVNIQVMDANDNTPTFPEI 517

  Fly   532 NLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYE-LQRPKGSGYIPFRLDNKNG--TIYVGGP 593
            : |:..|..:...|..:.|:.|.|.|||.||.:.|| |...:|.    |.::...|  ||..|..
Human   518 S-YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FIINKTTGLITIAPGVE 577

  Fly   594 LRRGR-IAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVG 657
            :..|| .|:.|:|.|. ..|:|||.|:..:.|||....:.       :|..|
Human   578 MIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQ-------SPPRF------------- 621

  Fly   658 QVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSS 722
                       .::||.|                       |:||..|
Human   622 -----------PQLMYSL-----------------------EISEAMR----------------- 635

  Fly   723 QSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRPVIEEINMNVIHFHVEENV 787
                                                                             
Human   636 ----------------------------------------------------------------- 635

  Fly   788 VGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDA 852
            ||.::        :||             :.|.|.                           ||:
Human   636 VGAVL--------LNL-------------QATDRE---------------------------GDS 652

  Fly   853 NIKLRYIIAN--QQEVVNKISITEDGTLLTL-TGLDREQQPSYELTVIVEYSTGLVSGAGIYQVN 914
               :.|.|.|  .|.|.|   ::|...:||| ..||||....|.|  |:..|.|...|.....||
Human   653 ---ITYAIENGDPQRVFN---LSETTGILTLGKALDRESTDRYIL--IITASDGRPDGTSTATVN 709

  Fly   915 IKVDDVNDNAPKFNAL--TYVGLINE--NCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSD 975
            |.|.|||||||.|:..  ..:.::.|  |..||       .:...|.|.|.|.:....| |:::
Human   710 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG-------QVKATDPDAGINGQVHYSL-GNFN- 765

  Fly   976 EFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRIS 1040
                                       |:|.:|                       |:|..
Human   766 ---------------------------NLFRIT-----------------------SNGSI---- 776

  Fly  1041 YTGKRGLDREKQQLYNLKIIAADTGGLSGYAH-------LTVLVADVNDNAPMFERISVFKDSRL 1098
            ||..: |:||.:..|.|.::|.|     |..|       |.:.|.|::||:|:|...:
Human   777 YTAVK-LNREVRDYYELVVVATD-----GAVHPRHSTLTLAIKVLDIDDNSPVFTNST------- 828

  Fly  1099 EIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKSR 1163
                ||..:|
Human   829 ----YTVLVE------------------------------------------------------- 834

  Fly  1164 RRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPMLRVHGV 1228
                             |:.|.||.:||:.|.|.|.|.|  :.|.::..:|:.
Human   835 -----------------ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH------------ 868

  Fly  1229 KYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFDT 1293
             :||:...:||||:             |...|.:...|
Human   869 -FFALHPFTGELSL-------------LRSLDYEAFPD--------------------------- 892

  Fly  1294 PEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVI 1358
                                 :.|:||:.:....:..|:.|.                      |
Human   893 ---------------------QEASITFLVEAFDIYGTMPPG----------------------I 914

  Fly  1359 ATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRST 1423
            ||              |.|.|.|:||..|.|                :.|     :||..:....
Human   915 AT--------------VTVIVKDMNDYPPVF----------------SKR-----IYKGMVAPDA 944

  Fly  1424 QPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAP----LFQIDSRDGTISTISRINGYNDYEH 1484
            ..||.:..:.|.|.|..|.....|.|  |..::|.|    :|:::...|.:  |:|:|
Human   945 VKGTPITTVYAEDADPPGLPASRVRY--RVDDVQFPYPASIFEVEEDSGRV--ITRVN------- 998

  Fly  1485 LN--------VSVIASDVGSPALSATAIVIVNLQGQAVTDP---PKSTPKPEPPANVTVFQHAYY 1538
            ||        :.|:|.|.|.|.:|::|.|.:     .|..|   |:.|.:...|..|:
Human   999 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKI-----LVLHPGEIPRFTQEEYRPPPVS------- 1051

  Fly  1539 EVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNM--LLYALKPFD 1601
            |:.........|....:|.|...:         :..|.:|.      .:...|:  ::|...|.|
Human  1052 ELATKGTMVGVISAAAINQSIVYS---------IVSGNEED------TFGINNITGVIYVNGPLD 1101

  Fly  1602 REHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAPKFRGNGQP 1666
            .|..:.|.||::||.|.....|.          |:...| |..::.:.|.|||::.|.|:  .:.
Human  1102 YETRTSYVLRVQADSLEVVLANL----------RVPSKS-NTAKVYIEIQDENNHPPVFQ--KKF 1153

  Fly  1667 IVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPARL----FGIDELSGNIR---LLGEL 1724
            .:..:.:.|.....|.||:|.|.|.|..:.:.|||:..|.:.    |.::..:|.|:   |...:
Human  1154 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1218

  Fly  1725 SRTEHIYGFDVKATDRMGADDGRSGIVNVFVYIINEAKQVRLVVAGM-PVEVERRIEGLMEALSD 1788
            .|:  .:.|.|.|||..|  .|.||..:|.|.::|:. .::::|:.: |..||::||.|.|.|..
Human  1219 RRS--YFKFQVIATDDYG--KGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIEDLTEILDR 1278

  Fly  1789 AI-----GKDVRVRLLEPYSGG----LEPAT--NAYIYAVDPHTNSIMEMEQLQDALAGLQLDA- 1841
            .:     |..|.|..:.....|    ||..|  :..:||:||.||..::..:|...|.|..||.
Human  1279 YVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDIN 1343

  Fly  1842 LQLQQQKLDGGKPMPRILELAEFGQLARPAHASASSFMGGLEFVTVVLLALISLGALIAACCYVC 1906
            ...|....:||    ||||:       |...|..|....| |.:.....||::|..:|..||...
Human  1344 KDFQPYYGEGG----RILEI-------RTPEAVTSIKKRG-ESLGYTEGALLALAFIIILCCIPA 1396

  Fly  1907 MRQKRRLWSQRDFSASDAGLTYTI----------------AGIGSP------------------- 1936
            :...  |.|.|.|....|..|.|.                |.:.:|
Human  1397 ILVV--LVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDS 1459

  Fly  1937 --------------RG----QKQRRQRQ----------QRHTQRCSKGSTGSQRPTSA----FMP 1969
                          ||    .:.|:.:|          :.|......||..|.:..||    |:.
Human  1460 SMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLS 1524

  Fly  1970 ESVCSSAQTQSTATATEKLEQQLHHHHQQQAMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKA 2034
            :                  |..|..|:.    ..::...|........|:.:::|...||..||:
Human  1525 D------------------EDDLSAHNP----LYKENISQVSTNSDISQRTDFVDPFSPKIQAKS 1567

  Fly  2035 AAVTSGGDGAVGVGSTPFVLKYNACQPVNNLNNYETSLFSLHSTGQDSGVEFLSSRELYETSPDS 2099
            .::....:....:.|....|.....:.|.|    ...:..|.        ::..:|:..|.
Human  1568 KSLRGPREKIQRLWSQSVSLPRRLMRKVPN----RPEIIDLQ--------QWQGTRQKAEN---- 1616

  Fly  2100 FQHGG---SKRGNNTEVLCPRHAK--AHLELRQPNTDSSDTYED--SLKTDEPLVAHNCRSANCE 2157
             ::.|   :|||::..:|....|.  ...|:||..|...:..|.  ||.:|         |:.|.
Human  1617 -ENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSD---------SSFCF 1671

  Fly  2158 HRQHQQHPS-----------HHPHYQNTRFE-------KRSCVRHSFSGVKDDLMQQSPQISLRP 2204
            .|.|....:           ..|:..::..|       .|.||.||      .|.::...|.:.|
Human  1672 PRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHS------SLSRRETPICMLP 1730

  Fly  2205 RGHALRNSMNDLEQRLHNLEQSFRRPLEFSKS 2236
                       :|.. .|:.::|..|...|.|
Human  1731 -----------IETE-RNIFENFAHPPNISPS 1750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	30/119 (25%)
		Cadherin_repeat	325..407	CDD:206637	23/92 (25%)
		Cadherin_repeat	416..524	CDD:206637	26/125 (21%)
		Cadherin_repeat	534..626	CDD:206637	32/95 (34%)
		Cadherin_repeat	641..>714	CDD:206637	9/72 (13%)
		CA	851..925	CDD:214520	30/76 (39%)
		CA	1026..1085	CDD:214520	18/65 (28%)
		Cadherin_repeat	1177..1280	CDD:206637	22/102 (22%)
		Cadherin_repeat	1289..1385	CDD:206637	13/95 (14%)
		Cadherin_repeat	1414..1510	CDD:206637	28/107 (26%)
		CA	1576..1658	CDD:214520	20/83 (24%)
		Cadherin_repeat	1666..1760	CDD:206637	28/100 (28%)
PCDH15	NP_001136235.1	ECD	36..145	CDD:408229	11/43 (26%)
		Cadherin_repeat	156..245	CDD:206637	24/99 (24%)
		CA	310..398	CDD:214520	22/93 (24%)
		Cadherin_repeat	404..510	CDD:206637	26/126 (21%)
		Cadherin_repeat	518..614	CDD:206637	34/101 (34%)
		Cadherin_repeat	626..718	CDD:206637	41/252 (16%)
		Cadherin_repeat	727..820	CDD:206637	29/161 (18%)
		Cadherin_repeat	828..926	CDD:206637	37/292 (13%)
		Cadherin_repeat	935..1032	CDD:206637	28/112 (25%)
		Cadherin_repeat	1050..1145	CDD:206637	26/127 (20%)
		Cadherin_repeat	1154..1248	CDD:206637	28/97 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1431..1451		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1608..1630		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1752..1773
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1935..1962