DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and CDH23

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_071407.4 Gene:CDH23 / 64072 HGNCID:13733 Length:3354 Species:Homo sapiens


Alignment Length:2687 Identity:582/2687 - (21%)
Similarity:912/2687 - (33%) Gaps:909/2687 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 HKYFNLTEHNATTLVVSLARSLERLVDRDVP--------RNLLKFRILCAGKQEKLEEGSYLSIT 166
            :|:::|   |:||   ...|:...::||:.|        |.::.....|.  :..|:..|..::.
Human   821 NKFYSL---NSTT---GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG--RPPLKATSSATVF 877

  Fly   167 VYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNSEVHFSMSTVPEQLSAD 231
            |.:.|:|||.|.|.|:|:|.:|.|.......|:: |.|.|.|:  ..|..|.:.|..        
Human   878 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ-VVAIDLDE--GLNGLVSYRMPV-------- 931

  Fly   232 GSPY--FALKSPHRPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQANTTITINVRDVDDLPPK 294
            |.|.  |.:.| ...:::...|||.:. |.:::|.:.|.|.|||...:.:|:||:|.||:|..|.
Human   932 GMPRMDFLINS-SSGVVVTTTELDRER-IAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPT 994

  Fly   295 FTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQD-SLNASLVYDIISGNERQLFRVNPHNGV 358
            |...||...::|     .||....:.:   :...|.| .|||.|.|.|..||....|.|...:.|
Human   995 FFPAVYNVSVSE-----DVPREFRVVW---LNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAV 1051

  Fly   359 MYLQKEIDLEEESLPGNTFVLQLEARQKDN-PLKK---ALARIEVEVLDLNDNVPEFEADYYNIS 419
            :.....:|.|..:    .::|.|||  .|| |:.|   ..|.:.|.|||:|||.|.|....|..|
Human  1052 VRTVVGLDRETTA----AYMLILEA--IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEAS 1110

  Fly   420 IVENLPTGFSVLQVNAVDRDQGE-------------------------------------NSEFL 447
            :.|::|.|.|:||:.|.|.|:||                                     ||..:
Human  1111 VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175

  Fly   448 -----YN-----------------------------------------------LVETKD----- 455
                 ||                                               :|:..|     
Human  1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240

  Fly   456 -----------AAGAFRIDSRTGW-ITVRDDRLLDREQRRSIQLNVEALERNPSY---------- 498
                       |.|.|.||..||. |||   ..||.|.:.|..:||.|.::.|.:          
Human  1241 GGLVNYRILSGAEGKFEIDESTGLIITV---NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302

  Fly   499 ----LDD-------------------------------------------------KHLKK---- 506
                ||:                                                 |.|.|    
Human  1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAI 1367

  Fly   507 --------------------------PGP---SKVQVEITLLDTNDNTPKFEHGNLYEFKVPINA 542
                                      .||   |.|:|.||:||.|||:|:|:..:.....:|.:.
Human  1368 TGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDC 1432

  Fly   543 PTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYI--PFRLDNKN---GTIYVGGPLRRGRIAVF 602
            |.|..:..|.|.|||.|.||.:::.|    .||.|  .|.:...|   |.::|..||.|..:..:
Human  1433 PVGQRVATVKAWDPDAGSNGQVVFSL----ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHY 1493

  Fly   603 ---VEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPL--GTSVGQVRTT 662
               |.|:|:.|.|.::...|.|..:::.   |:..:  :.:|:.:.|..|..:  ||:|.|||.|
Human  1494 ILQVVASDRGTPPRKKDHILQVTILDIN---DNPPV--IESPFGYNVSVNENVGGGTAVVQVRAT 1553

  Fly   663 ------------LIYEGGDEI------------------------MYDLLHTY-SEGVP------ 684
                        .|.||..::                        .|.|:.|. .||.|      
Human  1554 DRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATT 1618

  Fly   685 ----------------------------------------------------------------F 685
                                                                            |
Human  1619 HVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTF 1683

  Fly   686 AIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQSLVMSRSSS-PLTTIASPAELSDEGVL 749
            .|:...|:||..:||              :|..::...:|:::.:.. |:        ||..   
Human  1684 RIDRHMGVITAAKEL--------------DYEISHGRYTLIVTATDQCPI--------LSHR--- 1723

  Fly   750 ITNLTIHIVNKPEQKVPLRPVIEEINMNVIHF--------------------------------- 781
            :|:.|..:||           :.:||.||..|                                 
Human  1724 LTSTTTVLVN-----------VNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNG 1777

  Fly   782 HVEENVVGG----------IIGQLLYKNGINLVNNELGTY--------REMPSEPTSRNITMGSR 828
            .||.:::.|          :.|.|..:..:.|....:..|        |.||  |.|..:.:|.|
Human  1778 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMP--PLSSTMLVGIR 1840

  Fly   829 FRSRNR--------------SRSSKSKRRLPRRLVGDA----NIKLRY-IIANQQEVVNKISITE 874
            ....|.              |.:|.....:...|..||    |.:|.: |.|..:|....|:.| 
Human  1841 VLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT- 1904

  Fly   875 DGTLLTLTGLDREQQPSYELTVIV------------EYSTGLVSGAGIYQVNIKVDDVNDNAPKF 927
            .|.:.....||||:.|.|:||:.|            :|...|          |.:.|.|||.|.|
Human  1905 TGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL----------IFLSDENDNHPLF 1959

  Fly   928 NALTYVGLINENCVVGTELS-MNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSE--- 988
            ...||...:.||...||.|: :|..||..|||:...|....||.|..|..|.|....|..:.   
Human  1960 TKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSG 2024

  Fly   989 -------------------------NSTHHKM----------PSTTGAFNIFNLTDQWNDEFKYQ 1018
                                     |||.|.:          |:.:.|....:|.:.....|...
Human  2025 VIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089

  Fly  1019 ELHTTFMQTN------FKLSSGPYFR--------ISYTGKRGLDREKQQLYNLKIIAADTG--GL 1067
            ::..|...:.      :::.:|...|        :...|...:|||:|:.|.|.::|.|.|  .|
Human  2090 QVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPL 2154

  Fly  1068 SGYAHLTVLVADVNDNAPMF----ERISVFKDS------------------RLE------IREYT 1104
            ||.|.:|:|:.|:||:.|.|    :.:||.:.:                  :||      :.:..
Human  2155 SGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDD 2219

  Fly  1105 TDMEIYFVESSSGMTAPQATAAMMLAPP-------PYHIPGSPRFNVD--RERSVGAGLGVVARA 1160
            ||..:...|.:..:..  .|.::|:..|       .|.:..|...|..  .||||.     |..|
Human  2220 TDRLVPNQEDAFAVNI--NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS-----VPNA 2277

  Fly  1161 KSRRRMVRALTTKCPLF----------AIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVE 1215
            |.... |..:....|.|          .|.|....||.::.::|.|.|.|.|.|:.|.|. :.| 
Human  2278 KLTVN-VLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL-DLV- 2339

  Fly  1216 RTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTV----MD 1276
             .||...|.         |..:|::..|..:.......||.||...|...........|    :|
Human  2340 -PPGYVQLE---------DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVD 2394

  Fly  1277 VNNHAPTFKKSWYSFDTPEGEYKDSVLGQL----TAIDMDFGENANITYTLSDSHLPFTIKPASG 1337
            :|::.|.|.:..|.    |..::|..:|.:    ||.|.|.|..|.|.|:|.|....|.|.|.:|
Human  2395 INDNNPIFDQPSYQ----EAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTG 2455

  Fly  1338 VLKIGGQLDRELKDKYSFQVIATDNA--PVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVK 1400
            .:.:...||||.||.|....:|.||.  ....|..:||.|.:.|||:||.||:|           
Human  2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF----------- 2509

  Fly  1401 FIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDS 1465
                      ..|.:...:..:...||.|..:.|.|:|.  ..||.:.||:....::|  |.:|.
Human  2510 ----------SKPQFSTSVYENEPAGTSVITMMATDQDE--GPNGELTYSLEGPGVEA--FHVDM 2560

  Fly  1466 RDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPPANV 1530
            ..|.::|...:   ..||..:::|:|:|.|.|.|..|.:::|.     |.|...:.|....|.|.
Human  2561 DSGLVTTQRPL---QSYEKFSLTVVATDGGEPPLWGTTMLLVE-----VIDVNDNRPVFVRPPNG 2617

  Fly  1531 TVFQHAYYEVKLTENNEAPIEVMRLNLSAGLN----------PENYRWSLWLEE---GLDET--- 1579
            |:. |...|:.|..|   ..||...:...|||          ..|..|..::.:   ||.:|   
Human  2618 TIL-HIREEIPLRSN---VYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678

  Fly  1580 ----------------DAHPPFEYDAKNMLLYALKPFD---------------------REHISR 1607
                            |...|..|:....|..||:..|                     .||..|
Human  2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR 2743

  Fly  1608 YQL------RIRADR-----------LSREARNY------------------------------- 1624
            ..|      .:.||.           ...|.:|:                               
Human  2744 GTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSN 2808

  Fly  1625 -----ARVSYPVVDERIEGLSLNECRILVHIADENDNAPKFRGNGQPIVAVLPQSASFGYPVTRV 1684
                 .|...|.:| .:..|:|.|.|::  :.|.||..|:|  ......|.:...|..|..:.:|
Human  2809 RSWTPPRGPSPTLD-LVADLTLQEVRVV--LEDINDQPPRF--TKAEYTAGVATDAKVGSELIQV 2868

  Fly  1685 EANDLDEGLNAEIRYRLL------------NEPARLFGIDELSGNIRLLG-ELSRTEHIYGFDVK 1736
            .|.|.|.|.|:.:.|.:|            .:..::|.:..:.|.:|... .::.:...:..|:.
Human  2869 LALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIV 2933

  Fly  1737 ATDRMGADDGRSGIVNVFVYIINEAKQVRLVVAGMPVEVERRIEGLMEALSDAIGKDV---RVRL 1798
            |.|..|.:|  :.|:.  :||:.:.::|::|:..:|..|....|..:..||:..|..|   .|:.
Human  2934 ARDLAGHND--TAIIG--IYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQF 2994

  Fly  1799 LEPYSGGLEPA-TNAYIYAVDPHTNSIMEMEQLQDALAGLQLDALQLQQQKLDGGKPMPR----- 1857
            .....|.:..| |...|:.|:..||.|::::::               .|.:|..|...|     
Human  2995 HVDKKGRVNFAQTELLIHVVNRDTNRILDVDRV---------------IQMIDENKEQLRNLFRN 3044

  Fly  1858 --ILELAEFGQLARPAHASASSFMGGLEFVTVVLLALISLGALIAACCYVCMRQKRRLWSQRDFS 1920
              :|::.....:..|...||      |:...:||..|:.|.|::    :|.|....|...:|...
Human  3045 YNVLDVQPAISVRLPDDMSA------LQMAIIVLAILLFLAAML----FVLMNWYYRTVHKRKLK 3099

  Fly  1921 ASDAGLTYTIAGIGSPRGQKQRRQRQQRHTQR------------CSKGSTGSQRPTSAFMPESVC 1973
            |       .:||....||..........:...            |......:|......:||::.
Human  3100 A-------IVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLS 3157

  Fly  1974 SSAQTQSTATATEKLEQQLHHHHQQQAMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVT 2038
            ..|...::.|.|       |....::..|.:....:||    |...:||      .:|||...:.
Human  3158 EIADLWNSPTRT-------HGTFGREPAAVKPDDDRYL----RAAIQEY------DNIAKLGQII 3205

  Fly  2039 SGGDGAVGVGSTPFVL-------KYNACQPVNNLNNYETSLFSL-----------HSTGQDSGVE 2085
            .  :|.:.......||       |..|.:.|...::..:|:..|           ||.||.| :.
Human  3206 R--EGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSCHSSISELIQTELDEEPGDHSPGQGS-LR 3267

  Fly  2086 FLSSRELYETSPDSFQ--HGGS 2105
            |.....:....||...  ||.:
Human  3268 FRHKPPVELKGPDGIHVVHGST 3289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 32/108 (30%)
Cadherin_repeat 325..407 CDD:206637 29/86 (34%)
Cadherin_repeat 416..524 CDD:206637 52/309 (17%)
Cadherin_repeat 534..626 CDD:206637 29/99 (29%)
Cadherin_repeat 641..>714 CDD:206637 26/181 (14%)
CA 851..925 CDD:214520 26/90 (29%)
CA 1026..1085 CDD:214520 21/74 (28%)
Cadherin_repeat 1177..1280 CDD:206637 28/116 (24%)
Cadherin_repeat 1289..1385 CDD:206637 36/101 (36%)
Cadherin_repeat 1414..1510 CDD:206637 25/95 (26%)
CA 1576..1658 CDD:214520 27/174 (16%)
Cadherin_repeat 1666..1760 CDD:206637 22/106 (21%)
CDH23NP_071407.4 Cadherin_repeat 42..128 CDD:206637
Cadherin_repeat 136..231 CDD:206637
Cadherin_repeat 240..344 CDD:206637
Cadherin_repeat 352..456 CDD:206637
Cadherin_repeat 465..557 CDD:206637
Cadherin_repeat 566..667 CDD:206637
Cadherin_repeat 676..774 CDD:206637
Cadherin_repeat 782..886 CDD:206637 16/72 (22%)
Cadherin_repeat 894..990 CDD:206637 32/108 (30%)
Cadherin_repeat 999..1098 CDD:206637 34/112 (30%)
Cadherin_repeat 1106..1203 CDD:206637 17/96 (18%)
Cadherin_repeat 1218..1308 CDD:206637 20/92 (22%)
Cadherin_repeat 1317..1414 CDD:206637 13/96 (14%)
Cadherin_repeat 1426..1523 CDD:206637 29/103 (28%)
Cadherin_repeat 1533..1630 CDD:206637 18/96 (19%)
Cadherin_repeat 1638..1740 CDD:206637 18/137 (13%)
Cadherin_repeat 1752..1847 CDD:206637 15/96 (16%)
Cadherin_repeat 1855..1955 CDD:206637 27/110 (25%)
Cadherin_repeat 1963..2065 CDD:206637 25/101 (25%)
Cadherin_repeat 2075..2169 CDD:206637 22/93 (24%)
Cadherin_repeat 2180..2289 CDD:206637 21/116 (18%)
Cadherin_repeat 2301..2398 CDD:206637 27/108 (25%)
Cadherin_repeat 2406..2504 CDD:206637 35/101 (35%)
Cadherin_repeat 2513..2607 CDD:206637 27/105 (26%)
Cadherin_repeat 2620..2718 CDD:206637 21/101 (21%)
Cadherin_repeat 2735..2841 CDD:206637 16/108 (15%)
Cadherin_repeat 2850..2951 CDD:206637 21/104 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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