Protein Alignment Cad89D and PCDHB16

DIOPT Version :9

• Sequence 1: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Sequence 2: NP_066008.2
• Gene: PCDHB16 / 57717
• HGNCID: 14546
• Length: 776
• Species: Homo sapiens
• Alignment Length: 986
• Identity: 209/986 - (21%)
• Similarity: 333/986 - (33%)
• Gaps: 375/986 - (38%)

  Fly   807 ELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKIS 871
            |||:|..:  |.|.|...:.:..:......:..|.|:  .|::..         .|:|.:..|
Human    29 ELGSYSVV--EETERGSFVANLGKDLGLGLTEMSTRK--ARIISQ---------GNKQHLQLK-- 78

  Fly   872 ITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLI 936
             .:.|.||....||||:........|:.:...:.:...|:|..::|.|:||::|.|.....:..|
Human    79 -AQTGDLLINEKLDREELCGPTEPCILHFQVLMENPLEIFQAELRVIDINDHSPMFTEKEMILKI 142

  Fly   937 NENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGA 1001
            .||..:|||..:|||:   |.|.|.|                          |..::|: |.:..
Human   143 PENSPLGTEFPLNHAL---DLDVGSN--------------------------NVQNYKI-SPSSH 177

  Fly  1002 FNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGG 1066
            |.:  |..::.|..||.||                     ...:.||||::....|.:.|.|.|.
Human   178 FRV--LIHEFRDGRKYPEL---------------------VLDKELDREEEPQLRLTLTALDGGS 219

  Fly  1067 --LSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMML 1129
              .||.|.:.:.|.|:|||||.||:                  .||.|:
Human   220 PPRSGTAQVRIEVVDINDNAPEFEQ------------------PIYKVQ---------------- 250

  Fly  1130 APPPYHIPGSPRFNVDRERSVGAGLGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSA 1194
                  ||                                           |::|:|:.|..:||
Human   251 ------IP-------------------------------------------ENSPLGSLVATVSA 266

  Fly  1195 SDEDFGKNALLHYEL--QGEQVERTPGMPMLRVHGVKYFAIDKLSGEL----SVNYPLSANIEIM 1253
            .|.|.|.|..:.|.|  ..|.:.:|             ..::.::||:    .|::.:..:.|:
Human   267 RDLDGGANGKISYTLFQPSEDISKT-------------LEVNPMTGEVRLRKQVDFEMVTSYEV- 317

  Fly  1254 LNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENAN 1318
             .:..||..||.....|...|:|||::.|....|..:...||.. .:.|:...:..|.|.|.|..
Human   318 -RIKATDGGGLSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENS-PEIVVAVFSVSDPDSGNNGK 380

  Fly  1319 ITYTLSDSHLPFTIKPASG---VLKIGGQLDRELKDKYSFQVIATD-NAPVMQRMSSSVDVEVNV 1379
            ...::.:. |||.:||:..   .|.....||||.:.:|:..:..|| ..|   |:.:..::.|.:
Human   381 TISSIQED-LPFLLKPSVKNFYTLVTERALDREARAEYNITLTVTDMGTP---RLKTEHNITVQI 441

  Fly  1380 LDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGN 1444
            .|:|||.|.|    .||.                 |..::..:..|...:..::|.|:|:  ..|
Human   442 SDVNDNAPTF----TQTS-----------------YTLFVRENNSPALHIGSVSATDRDS--GTN 483

  Fly  1445 GLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIVIVNL 1509
            ..|.||:           :..:|                             |.|...::|.:|
Human   484 AQVTYSL-----------LPPQD-----------------------------PHLPLASLVSIN- 507

  Fly  1510 QGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEE 1574
                                                                             
Human   508 ----------------------------------------------------------------- 507

  Fly  1575 GLDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRA-DR----LSREARNYARVSYPVVDE 1634
                          |.|..|:||:..|.|.:..::.|:.| ||    |||||.
Human   508 --------------ADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREAL------------ 546

  Fly  1635 RIEGLSLNECRILVHIADENDNAP----KFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNA 1695
                     .|:||  .|.|||:|    ..:....|...::|::|..||.||:|.|.|.|.|.||
Human   547 ---------VRVLV--LDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA 600

  Fly  1696 EIRYRLL--NEPARLFGIDELSGNIRLLGELSRTEHIYGFDVKATDRMGA---DDG---RSGIVN 1752
            .:.|:||  .||. |||:...:|.:|....||..:       .|..|:..   |:|   ||....
Human   601 WLSYQLLKATEPG-LFGVWAHNGEVRTARLLSERD-------AAKQRLVVLVKDNGEPPRSATAT 657

  Fly  1753 VFVYIINEAKQ 1763
            :.|.:::...|
Human   658 LHVLLVDGFSQ 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520	17/73 (23%)
		CA	1026..1085	CDD:214520	16/60 (27%)
		Cadherin_repeat	1177..1280	CDD:206637	27/108 (25%)
		Cadherin_repeat	1289..1385	CDD:206637	25/99 (25%)
		Cadherin_repeat	1414..1510	CDD:206637	14/95 (15%)
		CA	1576..1658	CDD:214520	23/86 (27%)
		Cadherin_repeat	1666..1760	CDD:206637	33/101 (33%)
PCDHB16	NP_066008.2	Cadherin_2	32..112	CDD:285466	18/95 (19%)
		Cadherin_repeat	137..238	CDD:206637	37/153 (24%)
		Cadherin_repeat	246..343	CDD:206637	32/176 (18%)
		Cadherin_repeat	356..447	CDD:206637	25/95 (26%)
		Cadherin_repeat	455..557	CDD:206637	35/263 (13%)
		Cadherin_repeat	576..664	CDD:206637	32/95 (34%)
		Cadherin_C_2	685..768	CDD:293101

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000