DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and pcdh17

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_001154294.1	Gene:	pcdh17 / 561336	ZFINID:	ZDB-GENE-090608-3	Length:	1137	Species:	Danio rerio

Alignment Length:	1115	Identity:	232/1115 - (20%)
Similarity:	367/1115 - (32%)	Gaps:	425/1115 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 YDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLD 403
            :.::..:...|..|:|.:|::|.::.||.|......:...|.:|....|    |.:..|:||:.|
Zfish    54 FRVLENSAPHLIDVDPESGLLYTKQRIDRETLCRQNSKCQLSMEVFAND----KEICMIKVEIQD 114

  Fly   404 LNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRTGW 468
            :|||.|.|.::..:|.|.||...|.......|.|.|..||....|.:  |:|....|.:|.::
Zfish   115 INDNAPSFPSEQIDIDISENAAPGTRFPLAAAYDPDTKENGLKTYQI--TRDDYSIFSLDVKS-- 175

  Fly   469 ITVRDD----------RLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLDTND 523
               |.|          |.||||:|....|.:.|       .|.....|.|..::.|::|  |:||
Zfish   176 ---RGDGTKFPELVVQRSLDREERSHHTLIITA-------TDGGEYPKSGTMQINVKVT--DSND 228

  Fly   524 NTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIP------FRLD 582
            |:|.||..: |..::|.|||.|.||..:.|.|.|||.||.:.|..     |.|:|      |.:|
Zfish   229 NSPVFEQPS-YVVEIPENAPLGTVIIDLNATDSDEGINGQVTYSF-----SCYVPDRIKELFSID 287

  Fly   583 NKNGTIYVGGPL---RRGRIAVFVEATDQPTNPSERRFSLAVITIEVYATIDD-QAIDFV----G 639
            .:.|.|.:.|.:   ....|.:.|:|.||..||....   ..:|::|....|: .:|.||    |
Zfish   288 PRTGVIKIQGKIDFEENPIIEIDVQAKDQGPNPIPGH---CKVTVKVLDRNDNWPSIGFVAVRQG 349

  Fly   640 APYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFK 704
            |..|    |.|| ||.:..||.|                         ::.||
Zfish   350 AVSE----AATP-GTVIALVRVT-------------------------DKDSG------------ 372

  Fly   705 RKVYQFEAVANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRP 769

Zfish   373 ----------------------------------------------------------------- 372

  Fly   770 VIEEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNR 834
                                        :||
Zfish   373 ----------------------------RNG---------------------------------- 375

  Fly   835 SRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVE 899
                    :|..|::|:...||.....|..            |::|...||||.:..|.:|::.:
Zfish   376 --------QLQCRILGNVPFKLEENYDNFY------------TVVTDRPLDREVKDEYNITIVAK 420

  Fly   900 YSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAE 964
             ..|...........:|:.|.|||||:|..:.|:..:.||.:.|..|.   ::|..|.|.|.
Zfish   421 -DNGNPPLNSTKSFTVKILDENDNAPRFTKMVYLLQVPENNIPGEYLG---SVLAHDPDLGQ--- 478

  Fly   965 FRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNF 1029
                              |||.|    :..:||...                 :|..||::  |.
Zfish   479 ------------------NGTVS----YSLLPSNVS-----------------EESITTYV--NI 502

  Fly  1030 KLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGG--LSGYAHLTVLVADVNDNAPMFERISV 1092
            |.:.|..:.:     |..:.|:.:.::.|:.|.|:|.  |.....:.|.|.|||||.|:.. :.:
Zfish   503 KPTDGAIYAL-----RSFNYEQTKYFDFKVQAKDSGNPHLESNTTVRVSVLDVNDNIPVIV-LPL 561

  Fly  1093 FKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVV 1157
            .::...||                                  |:|          |:||.|
Zfish   562 LQNDTAEI----------------------------------HVP----------RNVGVG---- 578

  Fly  1158 ARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPM 1222
                      ..:||                   :.|.|.|||::..|.||:.....|.
Zfish   579 ----------HIITT-------------------VRAVDNDFGESGRLTYEISDGNEEH------ 608

  Fly  1223 LRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKS 1287
                   .|.||.::||:....||...:..::.|.:...|..|.|         ::..|....|:
Zfish   609 -------LFEIDSVTGEVRTAQPLWEEVTPVVELIIKVTDHGKPS---------LSAMAKLIVKA 657

  Fly  1288 WYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDK 1352
             ||...||||      .::.|...::..:..:..|||    ..:|...:.::.|..:..||.|:
Zfish   658 -YSGPLPEGE------PRINAEHHNWDMSLPLIVTLS----IISIMLLAAMITIAVKCKRENKE- 710

  Fly  1353 YSFQVIATDNAPVMQ----RMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFI--PSVADRTLM 1411
                 |.|.|..:.:    ::..|...::|..||...:.| :...|....:..:  ||:|..
Zfish   711 -----IRTYNCRIAEYSHPQLGKSKKKKINKNDIMLVQSE-VEERDTMNVMNVVSSPSLATS--- 766

  Fly  1412 LPVYKAYLDR 1421
             |:|..|..|
Zfish   767 -PMYFDYQTR 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637	17/67 (25%)
		Cadherin_repeat	416..524	CDD:206637	32/117 (27%)
		Cadherin_repeat	534..626	CDD:206637	32/100 (32%)
		Cadherin_repeat	641..>714	CDD:206637	11/72 (15%)
		CA	851..925	CDD:214520	17/73 (23%)
		CA	1026..1085	CDD:214520	17/60 (28%)
		Cadherin_repeat	1177..1280	CDD:206637	20/102 (20%)
		Cadherin_repeat	1289..1385	CDD:206637	22/99 (22%)
		Cadherin_repeat	1414..1510	CDD:206637	3/8 (38%)
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
pcdh17	NP_001154294.1	E_set	21..102	CDD:298831	10/47 (21%)
		Cadherin_repeat	131..229	CDD:206637	31/113 (27%)
		Cadherin_repeat	237..337	CDD:206637	33/108 (31%)
		Cadherin_repeat	351..443	CDD:206637	31/281 (11%)
		Cadherin_repeat	451..553	CDD:206637	33/153 (22%)
		Cadherin_repeat	568..656	CDD:206637	31/186 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910