DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and PCDHB11

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_061754.1	Gene:	PCDHB11 / 56125	HGNCID:	8682	Length:	797	Species:	Homo sapiens

Alignment Length:	835	Identity:	199/835 - (23%)
Similarity:	302/835 - (36%)	Gaps:	290/835 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1167 VRALTTKCPLFA-------IYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPMLR 1224
            ||.:....|:|:       |.|::|||...|..||.|.|.|.||:..|.:.          |...
Human   123 VRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTIS----------PNSH 177

  Fly  1225 VHGVKYFAI--DKLSGELSVNYPLSANIEIMLNLTVTDIDG---LKDSTCL-RFTVMDVNNHAPT 1283
            .| :|...|  ::...||.::..|.......|:..::.:||   .:..|.| |..|:|:|:::|.
Human   178 FH-IKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVDINDNSPE 241

  Fly  1284 FKKSWYSFDTPEGEYKDSVLGQL----TAIDMDFGENANITYTLS----DSHLPFTIKPASGVLK 1340
            |::::|.....|    :|:||.|    :|.|:|.|.|..|.||.|    |....|.|...||.:.
Human   242 FEQAFYEVKIRE----NSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTFEINQKSGEIT 302

  Fly  1341 IGGQLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSV 1405
            :...||.|..:.||..:.|||...:..:.:    |.::|:|:|||.||.              :|
Human   303 LRAPLDFETIESYSIIIQATDGGGLFGKST----VIIHVIDVNDNAPEI--------------TV 349

  Fly  1406 ADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQ---------------E 1455
            :..|..:|        ...|.|.|...:..|.|:  ..||.::.||...               |
Human   350 SSITSPIP--------ENTPETVVMVFSIQDIDS--GDNGRIVCSIPEDLPFVLKSSVENYYTLE 404

  Fly  1456 MQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSA---TAIVIVNLQGQAVTDP 1517
            .:.||    .|:.|.          :|   |:::..:|:|.|.|..   |.:::.::...|.|
Human   405 TERPL----DRESTA----------EY---NITITVTDLGIPRLKTEHNTTVLVSDVNDNAPT-- 450

  Fly  1518 PKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLS---AGLNPE-NYRWSLWLEEGLDE 1578
                           |....|.:.:.|||...:.:..::.:   :|.|.: ||  ||     |..
Human   451 ---------------FTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNY--SL-----LPP 493

  Fly  1579 TDAHPPF----EYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGL 1639
            .|.|.|.    ..:..|..|:||:..|.|.:..:..|:.|                 .|.....|
Human   494 QDLHLPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGA-----------------TDRGSPAL 541

  Fly  1640 SLNECRILVHIADENDNAP----KFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYR 1700
            | :|..:.|.:.|.|||:|    ..:....|...::|::|..||.||:|.|.|.|.|.||.:.|:
Human   542 S-SEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQ 605

  Fly  1701 LL--NEPARLFGIDELSGNI---RLLGELSRTEHIYGFDVKATDRMGADDGRSGIVNVFVYIINE 1760
            ||  .||. |||:...:|.:   |||.|....:|
Human   606 LLKATEPG-LFGVWAHNGEVRTARLLSERDAAKH------------------------------- 638

  Fly  1761 AKQVRLVVAGMPVEVERRIEGLMEALSDAIGKDVRVRLLEPYSGGLEPATNAYIYAVDPHTNSIM 1825
                ||||                     :.||         :|  ||..:|
Human   639 ----RLVV---------------------LVKD---------NG--EPPRSA------------- 654

  Fly  1826 EMEQLQDALAGLQLDALQLQQQKLDGGK----PMPRILELAEFGQLARPAHASASSFMGGLEFVT 1886
                           ...||...:||..    |:|.          |.||.|.|.|    |....
Human   655 ---------------TATLQVLLVDGFSQPYLPLPE----------AAPAQAQADS----LTVYL 690

  Fly  1887 VVLLALISLGALIAACCYVCMRQKRRLWSQRDFSASDAGLTYTIAGIGS---PRG 1938
            ||.||.:|...|.:...:|.:|..||         |.|      |.:||   |:|
Human   691 VVALASVSSLFLFSVLLFVAVRLCRR---------SRA------ASVGSCSVPKG 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520
		CA	1026..1085	CDD:214520
		Cadherin_repeat	1177..1280	CDD:206637	31/115 (27%)
		Cadherin_repeat	1289..1385	CDD:206637	32/103 (31%)
		Cadherin_repeat	1414..1510	CDD:206637	21/113 (19%)
		CA	1576..1658	CDD:214520	21/85 (25%)
		Cadherin_repeat	1666..1760	CDD:206637	28/98 (29%)
PCDHB11	NP_061754.1	Cadherin_2	30..112	CDD:311943
		Cadherin_repeat	140..238	CDD:206637	30/108 (28%)
		Cadherin_repeat	247..343	CDD:206637	32/103 (31%)
		Cadherin_repeat	356..447	CDD:206637	22/117 (19%)
		Cadherin_repeat	455..557	CDD:206637	29/126 (23%)
		Cadherin_repeat	576..664	CDD:206637	39/183 (21%)
		Cadherin_C_2	685..768	CDD:318652	19/65 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910