DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and cdh11

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_001015858.1	Gene:	cdh11 / 548575	XenbaseID:	XB-GENE-483599	Length:	794	Species:	Xenopus tropicalis

Alignment Length:	767	Identity:	180/767 - (23%)
Similarity:	276/767 - (35%)	Gaps:	250/767 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   780 HFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRL 844
            |.|.|:    |..||:|:::....|.|:.....|.    |..:..:..|..|...|
Frog    36 HGHHEK----GKEGQVLHRSKRGWVWNQFFVIEEY----TGPDPVLVGRLHSDVDS--------- 83

  Fly   845 PRRLVGDANIKLRYIIANQQEVVNKISITED--GTLLTLTGLDREQQPSYEL---TVIVEYSTGL 904
                 ||.  |::||::.  |....|.:.:|  |.:.....||||::..|.|   .|..|.:..|
Frog    84 -----GDG--KIKYILSG--EGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRETNKPL 139

  Fly   905 VSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQL 969
            ...:   :..:||.|:|||.|:|....|...:.|...|||.:..   :...|||: |.
Frog   140 EPPS---EFIVKVQDINDNPPEFLHENYHANVPEMSNVGTSVIQ---VTASDADD-PT------- 190

  Fly   970 QGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSG 1034
               |.:...:.|   :..|...:..:.:.||
Frog   191 ---YGNSAKLVY---SILEGQPYFSVEAQTG---------------------------------- 215

  Fly  1035 PYFRISYTGKRGLDREKQQLYNLKIIAAD----TGGLSGYAHLTVLVADVNDNAPMFERISVFKD 1095
                |..|....:|||.::.|::.|.|.|    .|||||...:|:.:.|||||.|.|
Frog   216 ----IIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKF-------- 268

  Fly  1096 SRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARA 1160
                                     ||:...|
Frog   269 -------------------------PQSAYPM--------------------------------- 275

  Fly  1161 KSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYE-LQGEQVERTPGMPMLR 1224
                             ::.|....|.:|.::.|.|.|.|:|.|:.|. |:|:      |..|..
Frog   276 -----------------SVSEAAVPGEEVGRIKAKDPDIGENGLIKYRILEGD------GAEMFE 317

  Fly  1225 V-------HGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDID-------GLKDSTCLRFTVM 1275
            :       .||  ..:.|:     |:|.......:.:......||       ..||:..::.:|.
Frog   318 ITADYQTQEGV--VKLKKV-----VDYETKKFYSMKVEAVNVHIDPRFLSRGPFKDTATVKISVE 375

  Fly  1276 DVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLP----FTIKPAS 1336
            |. :..|.|.:..|.|:..|....|:|:|::.|.|.| ..|:.|.|:: |.|..    |:|.|..
Frog   376 DF-DEPPIFLEHIYIFEVYENAPSDTVVGRVHAKDPD-AANSPIRYSI-DRHTDLDRFFSINPED 437

  Fly  1337 GVLKIGGQLDRELKDKYSFQVIATDNAPVMQRM-SSSVDVEVNVLDINDNRPEFIGYDDQTKAVK 1400
            ||:|....||||....::..||||:   :..|: .:.|.|.:.|||.|||.|||        |..
Frog   438 GVIKTTKGLDREESSWHNISVIATE---LHNRIHETRVPVAIKVLDKNDNAPEF--------AKP 491

  Fly  1401 FIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLY-----SIRHQEMQAPL 1460
            :...|.:..   |:.:.:|           .:||||||:  ..|||..:     .|.|..   |.
Frog   492 YEAFVCENA---PINQEFL-----------TITAIDKDD--TANGLRFFFSFPPEIVHPN---PN 537

  Fly  1461 FQI-DSRDGTIS-TISR-INGYNDYEHLNVSVIASDVGSPALSATAIVIVNL 1509
            |.| |.||.|.| .:.| :......:...|.|:.||.|||.:|:|..:.|.:
Frog   538 FTIVDKRDNTASIRVGRGVFSRQKQDLYLVPVVISDGGSPPMSSTNTLSVRI 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520	23/78 (29%)
		CA	1026..1085	CDD:214520	20/62 (32%)
		Cadherin_repeat	1177..1280	CDD:206637	25/117 (21%)
		Cadherin_repeat	1289..1385	CDD:206637	35/100 (35%)
		Cadherin_repeat	1414..1510	CDD:206637	31/104 (30%)
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
cdh11	NP_001015858.1	CA	79..157	CDD:214520	26/98 (27%)
		Cadherin_repeat	164..264	CDD:206637	32/154 (21%)
		Cadherin_repeat	273..376	CDD:206637	25/165 (15%)
		Cadherin_repeat	387..484	CDD:206637	35/101 (35%)
		Cadherin_repeat	491..590	CDD:206637	33/118 (28%)
		Cadherin_C	638..787	CDD:366437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11590
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000