DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad89D and Pcdh7

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	XP_006504082.1	Gene:	Pcdh7 / 54216	MGIID:	1860487	Length:	1275	Species:	Mus musculus

Alignment Length:	1715	Identity:	341/1715 - (19%)
Similarity:	534/1715 - (31%)	Gaps:	621/1715 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   651 PLGTSVGQVRTTLIYEGGDE---------IMYDL-LHTYSEGVPFAIEERSGIITV---IRELSE 702
            ||..|:...:..|.|...:|         :..|| :.|.|..|.|::|..|..:.:   ..|||.
Mouse    22 PLCFSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELST 86

  Fly   703 FKRKVYQFEAVANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPL 767
            .:|::                    .|...|...:     :.||.....:..:.::...:..|.|
Mouse    87 SERRI--------------------DREKLPQCQM-----IFDENECFLDFEVSVIGPSQSWVDL 126

  Fly   768 ---RPVIEEINMN-------VIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEP---- 818
               |.::.:||.|       |:...||||...|.:..|......:...|.:..| |:..||
Mouse   127 FEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY-ELLQEPGGGG 190

  Fly   819 ---TSRNI-------TMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVN-KISI 872
               ..|.:       ..|....|.:...|..|||||.....|.....     :.:..|.. :::.
Mouse   191 GSGEGRRLGPADSAPYPGGGGNSASGGGSGGSKRRLDAPEGGGGTSP-----SGRSSVFELQVAD 250

  Fly   873 TEDG----TLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYV 933
            |.||    .|:....|||||:.|||||:.|. ..|....:....:.:.:.|||||:|:|....|.
Mouse   251 TPDGEKQPQLIVKGALDREQRDSYELTLRVR-DGGDPPRSSQAILRVLITDVNDNSPRFEKSVYE 314

  Fly   934 GLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENSTH-HKMPS 997
            ..:.||...||.:....|   .|.|.|.|.:              ||||.|.::|:... .::..
Mouse   315 ADLAENSAPGTPILQLRA---TDLDVGVNGQ--------------IEYVFGAATESVRRLLRLDE 362

  Fly   998 TTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAA 1062
            |:|..::               ||.                        :|||:.......::|.
Mouse   363 TSGWLSV---------------LHR------------------------IDREEVNQLRFTVMAR 388

  Fly  1063 DTGGLSGYAHLTVL--VADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATA 1125
            |.|........||:  :.|.|||.|..|   :.|..|:.:::
Mouse   389 DRGQPPKTDKATVVLNIKDENDNVPSIE---IRKIGRIPLKD----------------------- 427

  Fly  1126 AMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVL 1190
                                       |:..||                      ||..|.|.:.
Mouse   428 ---------------------------GVANVA----------------------EDVLVDTPIA 443

  Fly  1191 QLSASDEDFGKNALLHYELQGE---QVERTPGMPMLRVHG----VKYFAIDKLSGELSVNYPLSA 1248
            .:..||.|.|:|.::...:.|:   |::     |.....|    .|||        |..:.||..
Mouse   444 LVQVSDRDQGENGVVTCTVVGDVPFQLK-----PASDTEGDQNKKKYF--------LHTSAPLDY 495

  Fly  1249 NIEIMLNLTVTDID----GLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAI 1309
            ......|:.:..:|    .|..:..|...|.|.|::.|.|.:|......||.......:..:.|.
Mouse   496 ETTREFNVVIVAVDSGSPSLSSNNSLVVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLAT 560

  Fly  1310 DMDFGENANITYTLSDSHL-PFTIKPASGVLKIGGQLDRELKDKYSFQVIATDNA-PVMQRMSSS 1372
            |.|.|:||.|.|:|..|.: .|.|.|.||.:.:...||||..|:|.|:|.|.|.. ||:|   .|
Mouse   561 DADSGKNAEIAYSLDSSVMGTFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQ---GS 622

  Fly  1373 VDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDK 1437
            ..|.|.|.|.|||.|:|                     |..|:..|:..:.||.:.|..:|.:|.
Mouse   623 TTVIVQVADKNDNDPKF---------------------MQDVFTFYVKENLQPNSPVGMVTVMDA 666

  Fly  1438 DNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSAT 1502
            |. |....:.||.    |..:.:|.|::..|||
Mouse   667 DK-GRNAEMSLYI----EENSNIFSIENDTGTI-------------------------------- 694

  Fly  1503 AIVIVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYR 1567

Mouse   695 ----------------------------------------------------------------- 694

  Fly  1568 WSLWLEEGLDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVV 1632
                                       |:...|||||.:.|..|::|                 |
Mouse   695 ---------------------------YSTMSFDREHQTTYTFRVKA-----------------V 715

  Fly  1633 DERIEGLSLNECRILVHIADENDNAPKFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEI 1697
            |......|.. ..:.:.:.|||||||...........:||.|::....|..|.|.|.|:|:||::
Mouse   716 DGGDPPRSAT-ATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADL 779

  Fly  1698 RYRLL-NEPARLFGIDELSGNIRLLGELSRTEHIYGFD---VKATDRMGADDGRSGIVNVFVYII 1758
            .|.:: ..|.:||.||..||.:.|:|:|  |:..||..   |:..|........:.:|:|||
Mouse   780 NYSIVGGNPFKLFEIDSTSGVVSLVGKL--TQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFV--- 839

  Fly  1759 NEAKQVRLVVAGMPVEVERRIEGLMEALSDAIGKDVRVRLLEPYSGGLEPATNAYIYAVDPHTNS 1823
            ||:.....|:...          ::.:|...:.:|:                     |.||
Mouse   840 NESVSNATVIDSQ----------IVRSLHTPLTQDI---------------------AGDP---- 869

  Fly  1824 IMEMEQLQDALAGLQLDALQLQQQKLDGGKPMPRILELAEFGQLARPAHASASSFMGGLEFVTVV 1888
                             :.::.:|:|                       :.....:.|:  :||:
Mouse   870 -----------------SYEISKQRL-----------------------SIVIGVVAGI--MTVI 892

  Fly  1889 LLALISLGALIAACCYVCMRQKRRLWSQRDFSASDAGLTYTIAGIGSPRGQKQR------RQRQQ 1947
            |:.||   .::|..|    |.|.:                    .|...|:|..      :|..:
Mouse   893 LIILI---VMMARYC----RSKNK--------------------NGYEAGKKDHEDFFTPQQHDK 930

  Fly  1948 RHTQRCSKGSTGSQRPTSAFMPESVCSSAQTQSTATATEKLEQQ------------------LHH 1994
            ....:..|.:..|::|..:.:.....|....|...:..|||...                  ..|
Mouse   931 SKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARH 995

  Fly  1995 HHQQQAMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVTSGGDGAVGVGSTPFVLKYNAC 2059
            :.....:.|.|.|.|.....::.|..:  |:|      .|......||. :.:|| ....:| :|
Mouse   996 YKSSSPLPTVQLHPQSPTAGKKHQAVQ--DLP------PANTFVGAGDN-ISIGS-DHCSEY-SC 1049

  Fly  2060 QPVN----------------------NLNNYETSLFSLHSTGQDSGVEFLSSRELYETSPDSFQH 2102
            |..|                      .:|.:....||:.|..||.....|.|  .|::..:..:.
Mouse  1050 QTSNKYSKQVDTVQTTNPPGHIEESCKINPFRRVTFSVVSQPQDPHQGSLQS--CYDSGLEESET 1112

  Fly  2103 GGSKRGNNTEVLCPRHAKAHLELRQPNTDSSDTYEDSLKTDEPLVAHNCRSANCEHRQHQQHPSH 2167
            ..||..:.     ||.....|        ..|.||.:  |.:..|      ...||.::...|.
Mouse  1113 PSSKSSSG-----PRLGALPL--------PEDNYERT--TPDGSV------GEAEHMENDSRPL- 1155

  Fly  2168 HPHYQNTRFEKRSCVRHSFSG-------VKDDLMQQSPQIS----LRPRG--HALRNS----MND 2215
             |....|....|.|..:..|.       ...:..:..|::|    :..||  ..|.|.    |.|
Mouse  1156 -PDVALTGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGD 1219

  Fly  2216 LEQRLHN--LEQSFR--RPLEFSKS 2236
            ..:.|.|  |..|:.  ....|||:
Mouse  1220 RNRNLLNKKLTSSYETFSAASFSKN 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637	18/75 (24%)
		CA	851..925	CDD:214520	22/78 (28%)
		CA	1026..1085	CDD:214520	12/60 (20%)
		Cadherin_repeat	1177..1280	CDD:206637	26/113 (23%)
		Cadherin_repeat	1289..1385	CDD:206637	36/97 (37%)
		Cadherin_repeat	1414..1510	CDD:206637	17/95 (18%)
		CA	1576..1658	CDD:214520	17/81 (21%)
		Cadherin_repeat	1666..1760	CDD:206637	31/97 (32%)
Pcdh7	XP_006504082.1	Cadherin_repeat	35..139	CDD:206637	23/128 (18%)
		Cadherin_repeat	147..304	CDD:206637	42/163 (26%)
		Cadherin_repeat	312..411	CDD:206637	30/154 (19%)
		Cadherin_repeat	429..531	CDD:206637	28/136 (21%)
		Cadherin_repeat	541..635	CDD:206637	36/96 (38%)
		Cadherin_repeat	643..738	CDD:206637	32/241 (13%)
		Cadherin_repeat	749..839	CDD:206637	29/91 (32%)
		Protocadherin	842..1053	CDD:369839	46/325 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000