Protein Alignment Cad89D and CDHR5

DIOPT Version :10

• Sequence 1: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Sequence 2: NP_068743.3
• Gene: CDHR5 / 53841
• HGNCID: 7521
• Length: 845
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 96/370 - (25%)
• Similarity: 164/370 - (44%)
• Gaps: 80/370 - (21%)

  Fly   141 RNLLKFRILCAGKQEKLEEG----SYLSITVYIEDVNDNAPEFLNVPYVVDVDENTSIESIIF-- 199
            ::||:.::||       :.|    :.|.:.|.:.|||||||||......:.|:|:|.:.|.:.
Human    89 KSLLEAQLLC-------QSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPE 146

  Fly   200 EGVQAFDRDKPNTPNSEVHFSMSTVPEQLSADGSPYFALKSPHRPLLILKRELDFDNGIRQFKLP 264
            ..:||.||||.:.    :.:::    ::::|..|.||:|.|.:||.|.|.|.|||      ::.|
Human   147 TQLQAEDRDKDDI----LFYTL----QEMTAGASDYFSLVSVNRPALRLDRPLDF------YERP 197

  Fly   265 -IFAW--------DRGTPANQANTTITINVRDVDDLPP-----KFTEG--VYRTRINEFYPMTGV 313
             :..|        :...|::.|..|:.:||...|..||     .|::|  ..:.:.:...| ||.
Human   198 NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVP-TGH 261

  Fly   314 PIRIPLYFAP-PIMAFDQD-SLNASLVYDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPG-N 375
            .:..||...| ||.|.|.| .:|..::|.|..||....|.::|.:|.:.:.:       |:|. .
Human   262 ILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVAR-------SVPSPM 319

  Fly   376 TFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNISIVENLPTGFSV---------L 431
            ||:|.::.:|.| ..:.::.::.||.:....:.|.|....|..::......|..|         |
Human   320 TFLLLVKGQQAD-LARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPL 383

  Fly   432 QVNAVDRDQGE-NSEFLYNLVE---------------TKDAAGAF 460
            ::.|.|.:..: ||...|.:..               |...||||
Human   384 RIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAF 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	31/117 (26%)
		Cadherin_repeat	325..407	CDD:206637	21/83 (25%)
		Cadherin_repeat	416..524	CDD:206637	14/70 (20%)
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520
		CA	1026..1085	CDD:214520
		Cadherin_repeat	1177..1280	CDD:206637
		Cadherin_repeat	1289..1385	CDD:206637
		Cadherin_repeat	1414..1510	CDD:206637
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
CDHR5	NP_068743.3	Cadherin_repeat	37..120	CDD:206637	10/37 (27%)
		Cadherin_repeat	274..343	CDD:206637	19/76 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..661
		PHA03247	<452..651	CDD:223021
		4 X 31 AA approximate tandem repeats	540..645
		Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000269|PubMed:24725409	691..845
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..789
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	811..845