DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and pcdh15b

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:XP_009304712.1 Gene:pcdh15b / 503521 ZFINID:ZDB-GENE-050214-1 Length:1964 Species:Danio rerio


Alignment Length:1989 Identity:421/1989 - (21%)
Similarity:662/1989 - (33%) Gaps:749/1989 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 SLERLVDRDVPRNL--LKFRILCAGKQEKLEEGSYL--SITVYIEDVNDNAPEFLNVPYVVDVDE 190
            |..|::|||.|..:  :..::.|..:.    .|:.:  .:.:.:.|.|||||.|....|.|.|:|
Zfish   105 STGRVLDRDPPSYIQSIVVQVQCTNEL----VGTVILHEVRIVVRDRNDNAPRFQQPRYYVAVNE 165

  Fly   191 NTSIESIIFEGVQ----AFDRDKPNTPNSEVHFSMSTVPEQ----------LSADGSPYFALKSP 241
            .|.:.:.||.|..    |.|.|  :.||.::.:::...|..          |:..||        
Zfish   166 LTPVGTTIFSGFTGNNGAVDID--DGPNGQIEYTIQYNPRDPTTNRTFDIPLTLSGS-------- 220

  Fly   242 HRPLLILKRELDFDNGIRQFKLPIFAWDRG-TPANQ--ANTTITINVRDVDDLPPKFTEG----- 298
                ::|:..|:::. |.::.:.|.|.||. .|.::  |.||:|::|.|.|||.|.|...     
Zfish   221 ----VVLRERLNYEE-ITRYLVIIQANDRAPNPKDRLTATTTLTVDVLDGDDLGPMFLPCSLVDN 280

  Fly   299 -------VYRTRINEFYPMTGVPIRI-PLYFAPPIMAFDQD------SLNASLVYDIISGNER-- 347
                   .||..|.|...    |.|: |:...|||.|.|||      |....::|.|:.|...  
Zfish   281 TRDCKPLTYRASILELTD----PSRVNPVNVTPPIQAVDQDRNIQPPSDRPGILYSILIGKPETY 341

  Fly   348 -QLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEF 411
             :.|.:|.....:.|.|.|..|:.    ..|.|.::|.|.:.....|.|.:.:||||.|:..|.|
Zfish   342 GEFFWMNRSTAELQLLKAISREKY----QHFDLVIKAEQDNGHPLPAFANLHIEVLDENNQAPYF 402

  Fly   412 EADYYNISIVENLPTGFSV---------LQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRTG 467
            :...|:..|.|:.|.|.::         |.:..:|.|          :.||||......:|:..|
Zfish   403 QVATYHGFISESAPLGTTISSSANLSTPLAIIVLDND----------IEETKDPMVRISLDNYNG 457

  Fly   468 WITVRDDRLLDREQRRSIQLNVEALERNPSY----LDDKHLKKPGPSKVQVEITLLDTNDNTPKF 528
            ...|....::    |....|.....|..|:|    :....:::..|  |.:.||::|.|||||.|
Zfish   458 IFAVTAGGIV----RYLTLLRPVDHEEQPTYAFTMIASDGVQESAP--VTINITVIDANDNTPTF 516

  Fly   529 EHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNGTIYVGGP 593
            .:.: |...|..:...|..:.|:.|.|.|:||||.:.|::                         
Zfish   517 PNVS-YGVSVYTDMQPGDPVLQLTALDADDGPNGLVSYKI------------------------- 555

  Fly   594 LRRGRIAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVGQ 658
                                     ||                                      
Zfish   556 -------------------------LA-------------------------------------- 557

  Fly   659 VRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQ 723
                     ||:            ..|.|.:.:|:|||:                       .|.
Zfish   558 ---------GDQ------------GHFTINDCTGVITVL-----------------------PSV 578

  Fly   724 SLVMSRSSSPLTTIASPAELSDEGVL------ITNLTIHIVNKPEQKVPLRPVIEEINMNVIHFH 782
            :|.:.||.: ||..|     :|.|..      ||.:.|.::....|..|             .||
Zfish   579 NLTVGRSYA-LTVRA-----TDNGPTAQRRSSITTVYIEVLPPNNQSPP-------------RFH 624

  Fly   783 VEENVVGGIIGQLLY--------KNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSK 839
                       ||:|        :.|..|:|.: .|.||  .:|.:.:|..              
Zfish   625 -----------QLVYSLEISEAMRTGATLLNIQ-ATDRE--KDPITYSIQK-------------- 661

  Fly   840 SKRRLPRRLVGDANIKLRYIIANQQEVVNKISITE-DGTLLTLTGLDREQQPSYELTVIVEYSTG 903
                      ||.|              |...::: .|.||....||||....|.|||..  |.|
Zfish   662 ----------GDPN--------------NVFEVSQTSGLLLLAKTLDREITDHYTLTVTA--SDG 700

  Fly   904 LVSGAGIYQVNIKVDDVNDNAPKFNALTYVGL-INE---NCVVGTELSMNHAILIQDADEGPNAE 964
            ...|.....|||.|.|||||.|:|:.|..:.| :.|   |..||       .:...|.|.|.|.:
Zfish   701 KPDGTSTTTVNIAVTDVNDNDPEFDPLLPLNLTVQEEEANAFVG-------QVKATDLDLGINGQ 758

  Fly   965 FRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNF 1029
            .|.:|. .|.|.|.|      |...|....||                                 
Zfish   759 VRYRLV-SYPDLFRI------SPNGSIFTAMP--------------------------------- 783

  Fly  1030 KLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAH----LTVLVADVNDNAPMFERI 1090
                             ||||::..|:|.:.|:|  |......    |::.|.||:||:|:|   
Zfish   784 -----------------LDREERAQYDLIVQASD--GAKDPRRTTITLSITVLDVDDNSPVF--- 826

  Fly  1091 SVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLG 1155
                                                   :||.||.                   
Zfish   827 ---------------------------------------SPPAYHA------------------- 833

  Fly  1156 VVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGM 1220
                                  .:.|::||||.:|.:||.|.|...|  :.|.::.::..     
Zfish   834 ----------------------TLPENSPVGTVILNISALDPDLDAN--VTYRIRTKEAR----- 869

  Fly  1221 PMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFK 1285
                    :.||::.|:|||.|             |...|.:.|..:...:..|::.        
Zfish   870 --------ELFAVNSLTGELKV-------------LRSLDFEKLLPNATTQTFVVEA-------- 905

  Fly  1286 KSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELK 1350
                                     :|.|                     ||.:..|        
Zfish   906 -------------------------LDGG---------------------SGKMPPG-------- 916

  Fly  1351 DKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVY 1415
                                 ...|.|.|||:||                 .|.|..:||    |
Zfish   917 ---------------------LASVTVTVLDMND-----------------FPPVFSQTL----Y 939

  Fly  1416 KAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEM--QAPLFQIDSRDGTISTISRING 1478
            :..:..:...||.|..:.|.|.|..|.....|.|....::.  ...:|.::...|.|.|  |:| 
Zfish   940 RGMVAPNAVKGTIVTAVHAEDLDPPGTAASRVHYKADLEQFPYSTSIFDVEENSGNIFT--RVN- 1001

  Fly  1479 YNDYEH--LNVSVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPPANVTVF-QHAYYEV 1540
            .|:..:  .:::|||.|.|.|.....::|.:.:...::               :.|| |..|...
Zfish  1002 LNEEPNTKFSLAVIAYDDGEPMKFNKSLVEITVLQLSI---------------IPVFTQEEYRFA 1051

  Fly  1541 KLTENNEAPI-EVMRLNLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNMLLYALKPFDREH 1604
            .::||  ||: .|..:.|:|.:|..       :...:.|.:....|..:....::...||.|.|.
Zfish  1052 PVSEN--APVGTVAGVILAAAINQT-------IVYSIIEGNEGGEFVVNNNTGVISTAKPLDYES 1107

  Fly  1605 ISRYQLRIRADRLSREARNYARVSYPVVDERIEG-LSLNECRILVHIADENDNAPKFRGNGQPI- 1667
            .|.|.||:.||            |..||...:.. ...|..::.:.:.||||:.|.|.   :|. 
Zfish  1108 NSSYVLRVEAD------------SMRVVSSNLRAPAKSNTAKVFIDVQDENDHPPVFT---KPFY 1157

  Fly  1668 VAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPAR----LFGIDELSGNIR---LLGELS 1725
            :..:.:.|.....|.:|:|.|.|.|..:.:.|||:..|..    .|.|:..:|.|:   :...:.
Zfish  1158 LGGVAEDAKTFTSVLQVQALDKDTGNYSAMLYRLIIPPTTDGKDGFVIEPFTGVIKTAIMYRNMR 1222

  Fly  1726 RTEHIYGFDVKATDRMGADDGRSGIVNVFVYIINEAKQVRLVVAGMPVEV----ERRIEGLMEA- 1785
            |:  .:.|||.|||..|  :|.|....|.|.::|:. .:::||:.:|..|    :.|:.|::|. 
Zfish  1223 RS--YFKFDVVATDNYG--EGLSSSAQVVVSVVNQL-DMQVVVSNVPPTVVEQNKDRLIGILERY 1282

  Fly  1786 LSDAI-GKDVRVRLL--EPYSGGLE----PATNAYIYAVDPHTNSIMEMEQLQDALAGLQLDALQ 1843
            :.|.| |..|.:..:  ..:..|.|    ..::..:||:||.||..:..::|...|.|..||..:
Zfish  1283 VQDQIPGAKVVMESIGARRFGDGYEQEDYTKSDLMVYAIDPLTNRALSRQELFKFLDGKLLDINK 1347

  Fly  1844 LQQQKLDGGKPMPRILELAE---FGQLARPAHASASSFMGGLEFVTVVLLALISLGALIAACCYV 1905
            ..|..|..|   .||||:..   ...:.|..|:     :|..|.      ||::|..:|..||..
Zfish  1348 EFQPYLGRG---GRILEIRTPDVVESVTRAVHS-----VGYTEG------ALLALAVIIILCCIP 1398

  Fly  1906 CMRQKRRLWSQRDFSASDAGLTYTIAGIGSPRGQKQRRQRQQRHTQRCSKGSTGSQRPTSAFMPE 1970
            .:              ....:||              ||.::|..:...........||.     
Zfish  1399 AI--------------LIVIITY--------------RQFKERQAECAKTARIQMALPTG----- 1430

  Fly  1971 SVCSSAQTQSTATATEKLEQQL--------HHHHQQQAM 2001
                    :|...||..|.::|        .|..|||.:
Zfish  1431 --------KSGGAATNNLYEELGDSTMRGYGHQEQQQLL 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 31/123 (25%)
Cadherin_repeat 325..407 CDD:206637 26/90 (29%)
Cadherin_repeat 416..524 CDD:206637 26/120 (22%)
Cadherin_repeat 534..626 CDD:206637 14/91 (15%)
Cadherin_repeat 641..>714 CDD:206637 8/72 (11%)
CA 851..925 CDD:214520 26/74 (35%)
CA 1026..1085 CDD:214520 15/62 (24%)
Cadherin_repeat 1177..1280 CDD:206637 23/102 (23%)
Cadherin_repeat 1289..1385 CDD:206637 11/95 (12%)
Cadherin_repeat 1414..1510 CDD:206637 24/99 (24%)
CA 1576..1658 CDD:214520 20/82 (24%)
Cadherin_repeat 1666..1760 CDD:206637 28/101 (28%)
pcdh15bXP_009304712.1 Cadherin_repeat 159..267 CDD:206637 31/122 (25%)
Cadherin_repeat 288..396 CDD:206637 34/115 (30%)
Cadherin_repeat 406..512 CDD:206637 26/121 (21%)
Cadherin_repeat 520..616 CDD:206637 34/234 (15%)
Cadherin_repeat 627..720 CDD:206637 34/135 (25%)
Cadherin_repeat 729..822 CDD:206637 32/158 (20%)
Cadherin_repeat 831..929 CDD:206637 35/249 (14%)
Cadherin_repeat 939..1035 CDD:206637 24/98 (24%)
Cadherin_repeat 1047..1148 CDD:206637 28/121 (23%)
Cadherin_repeat 1161..1240 CDD:206637 23/82 (28%)
NESP55 <1784..1894 CDD:115071
SRRM_C 1846..>1893 CDD:291883
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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