DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and Cad99C

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_001189311.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster


Alignment Length:2298 Identity:462/2298 - (20%)
Similarity:716/2298 - (31%) Gaps:943/2298 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 VDRDVPRNL--LKFRILC----AGKQEKLEEGSYLSITVYIEDVNDNAPEFLNVPYVVDVDENTS 193
            :||| ..||  :.|::.|    .||:..      :.|.|.:.|:|||||.|:|.||.|.|.|:|.
  Fly    99 LDRD-EENLSHIVFQVSCTTRSTGKKRT------IPIIVRVSDINDNAPRFMNTPYEVTVPESTP 156

  Fly   194 IESIIFEGVQAFDRD-----------KPNTPNSEVHFSMSTVPEQLSADGSPYFALKSPHRPLLI 247
            :.:.||..:||.|:|           ...:||       ||..|:.||||...||:..||:..:.
  Fly   157 VGTTIFRNIQALDKDAGVNGLVEYFIAEGSPN-------STNVEKYSADGYGTFAISFPHQGQVT 214

  Fly   248 LKRELDFDNGIRQFKLPIFAWDRGTPANQAN-----TTITINVRDVDDLPPKFTEGVYR------ 301
            :.:.|||:. |:.:.|.|.|.||.  .|.|:     ||:|:|:.|.:||.|.|   :|.      
  Fly   215 VAKTLDFEK-IQTYYLTIVASDRA--RNTADRLSSTTTLTVNIADSNDLDPSF---IYSGCVSLD 273

  Fly   302 -TRINEFY-------PMTGVPIRIPLYFAPPIMAFDQDSLNASLVYDIIS---GNERQLFRVNPH 355
             ..||..|       .:.||...:|    ..|.|.|.|::|:.:.|...|   ||....|:::..
  Fly   274 GACINPEYSASVPAGSLLGVLTVLP----ERIQAVDLDTINSPIRYSFASGMPGNYADYFQIDES 334

  Fly   356 NGVMYLQKEIDLE-----------EESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVP 409
            .||:...|.:|..           ||..||              |.:...|::|:.|..::.|.|
  Fly   335 TGVLKQTKAVDTSTAKKYDIIVKAEEVSPG--------------PQRFTTAKLEIFVKPVDANPP 385

  Fly   410 EFEADYYNISIVENLPTGFSVLQVN-------AVDRDQGENS---EFLYNLVETKDAAGAFRIDS 464
            ...:......:.||.|.|..||..:       ..|.|..::.   :::|.|.             
  Fly   386 VISSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDSDPKPDYIYELT------------- 437

  Fly   465 RTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQV--------------- 514
             |....|..|.:|        .:|.|.|:|:|        ..||..|.||               
  Fly   438 -TPSFNVTGDGIL--------VVNEENLDRDP--------PAPGRFKFQVVAREPRTNAASAPLS 485

  Fly   515 -EITLLDTNDNTPKFEHGNLYEFKVPINAPTG-----YVIGQVVAHDPDEGPNGHLLYELQRPKG 573
             .:.|.|.|||.||.      ....||:...|     .::.||.|.|.|||||..:.|.:.....
  Fly   486 LTVHLRDVNDNAPKL------AMVAPISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSN 544

  Fly   574 SGYIPFRLDNKNGTIYVGGPLRRG-RIAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDF 637
            :|...|.::...|.|...|.|..| :.::.|:|||.....|:     |::.:.|           
  Fly   545 NGIQKFTINATTGEIRTQGRLLAGEQYSITVQATDIGGLSSQ-----AIVEVSV----------- 593

  Fly   638 VGAPYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSE 702
              .|     |.||                                                :...
  Fly   594 --TP-----GPNT------------------------------------------------KPPR 603

  Fly   703 FKRKVYQFEAVANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPL 767
            |::.:|:.:.                                .||.                   
  Fly   604 FQKPIYEVQV--------------------------------SEGA------------------- 617

  Fly   768 RPVIEEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSR 832
                 |||..|...|.|:.....::..::..|.:                   |...:|.     
  Fly   618 -----EINSTVTVVHAEDPENDAVVYSIISGNDL-------------------RQFAVGQ----- 653

  Fly   833 NRSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVI 897
                                                     |.|.::.:..||||....|:|.:.
  Fly   654 -----------------------------------------ESGVIIVIRKLDRESLTRYQLILK 677

  Fly   898 VEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNA--LTYVGLINENCVVGTELSMNHAILIQDADEG 960
            .|.:.||.|.|   .|||||.|:||..|:|.|  |.||..:.|. .....:.:.||   .|||||
  Fly   678 AEDTGGLSSSA---TVNIKVTDINDKNPEFEASTLPYVFQVEEG-KAQASVGVVHA---TDADEG 735

  Fly   961 PNAEFRVQLQGDYSDEFSIEY-VNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTF 1024
            .|||.      .||....|.: :|.||.|..|                    ..|..|::|:.  
  Fly   736 INAEI------TYSIPTDIPFTINATSGEILT--------------------AKELDYEQLNE-- 772

  Fly  1025 MQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNAPMFER 1089
                        ::...|.|.|              |.|  ...|.|.:||:|.|:.|..|.   
  Fly   773 ------------YKFVVTAKDG--------------APD--ARLGTASVTVMVLDLPDEVPK--- 806

  Fly  1090 ISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGL 1154
               |.|:|:::                                  |||.:.              
  Fly   807 ---FSDARIDV----------------------------------HIPENE-------------- 820

  Fly  1155 GVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPG 1219
                                      |:..|.|    :.|.|.|                    .
  Fly   821 --------------------------ENFLVAT----VQAFDPD--------------------S 835

  Fly  1220 MP----MLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNH 1280
            ||    :||....:.|.:.:.|||                  |..|.||                
  Fly   836 MPEITYVLRKGNAELFKVSEKSGE------------------VRTIKGL---------------- 866

  Fly  1281 APTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQL 1345
                            :|:.....|||...::...|.                |...:|.:    
  Fly   867 ----------------DYESQKQHQLTIGTIENDGNG----------------PGDTILLV---- 895

  Fly  1346 DRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTL 1410
                                       ||||    |.||..|.||...|..       :|.|   
  Fly   896 ---------------------------VDVE----DRNDLPPRFITVPDPV-------TVND--- 919

  Fly  1411 MLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISR 1475
                     |:..  ||.:..|.|||.|....|| :|.|.|..:......||:|...|.:.....
  Fly   920 ---------DQGI--GTIIATLPAIDGDGTSPGN-VVRYEIVGRGKAPKYFQVDPDTGAVRIRDE 972

  Fly  1476 INGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQ---------------------------GQA 1513
            :....|.|: .|.:.|.|:|.|.||:.|.:.|::.                           |.|
  Fly   973 LRKEEDTEY-QVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLA 1036

  Fly  1514 VTDPPKSTPKPEP-PANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEG-- 1575
            .:|...:|..||. .||.|        :||       |:::. :.::|..|..:|.......|  
  Fly  1037 FSDDSYTTSVPESMEANST--------LKL-------IQIVN-SKTSGDGPPAFRCEFVSGNGGG 1085

  Fly  1576 ---LDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIE 1637
               |...|       ...|:||  ::|.|.|:.|.|.|::|       ..::.....|:.|    
  Fly  1086 IFNLSSAD-------HGCNLLL--IQPLDFENKSSYSLQLR-------LTSHRYFVNPLKD---- 1130

  Fly  1638 GLSLNECRILVHIADENDNAPKF-----RGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEI 1697
                 ...:.:.:.|||||||:|     ||.......|:.:.......:.:|.|.|.|.|....:
  Fly  1131 -----TTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGKFGTV 1190

  Fly  1698 RYRL-------LNEPARLFGIDELSGNIRLLGEL-SRTEHIYGFDVKATDRMGADDG----RSGI 1750
            ||.|       :|.|...|.:.|.:|.:|..... :..:....|.|:|.|..|.:.|    |:.|
  Fly  1191 RYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSHRTRARI 1255

  Fly  1751 VNVFVYIINEAKQVRLVVAGMPVEVERRIEGLMEALSDAIGKDVR------VRLLEPYSG---GL 1806
            |      :|:...:..:....|               :|...|:|      ..||:..:|   |:
  Fly  1256 V------VNKLADINRMALSFP---------------NAAPSDLRNYYTELEELLDKKTGLVSGI 1299

  Fly  1807 E------------------PATNAYIYAVDPHT-------NSIMEMEQLQDALAGLQLDALQLQQ 1846
            |                  .||:.:.|.:||.|       :||:|...|:.| |..:|:.     
  Fly  1300 ERMSSQKYLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKDSIVETTLLEPA-ARSELNI----- 1358

  Fly  1847 QKLDGGKPMPRI--------LELAEFGQLARPAHASASS-FMGGLEFVTVVLLALISLGALIAAC 1902
                   .:||.        ||..|.....:.|.|..:. |...|..:::|:|.|.::|.:    
  Fly  1359 -------ALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGII---- 1412

  Fly  1903 CYVCM--------RQKRRLWS-------------QRDFSASDAGLTYTIAGIGSPRGQK------ 1940
             |:|:        :|:.|.:|             |:..|||:     |||.:.....|.      
  Fly  1413 -YICISWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASE-----TIANMKEYETQMLAMAVP 1471

  Fly  1941 -------QRRQRQQRH----------TQRCSKGSTGSQRPTSAFMPESVCSSAQTQSTAT-ATEK 1987
                   |.....:.|          |.:.:....|...|           |....:||| ||.:
  Fly  1472 PDVDDDLQLDFSAKNHAFSLDNVSYITHKENTNGGGQSSP-----------SHSDATTATIATLR 1525

  Fly  1988 LEQQLHHHHQQQAMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVTSGGDGAVGVGSTPF 2052
            ..:.|::......:|...:.:.:....:...:.....:..|.:.|.:..:|.|.           
  Fly  1526 RHKNLNNASMNNNLAINNRQNTFNRTLEMNTRNNANPLASPPNGALSGTLTLGR----------- 1579

  Fly  2053 VLKYNACQPVNNLNNYETSLFSLHSTGQDSGVEFLSSRELYETSPDSFQHGGSKRGN-------- 2109
             :|:      .|.|:|:...:::..||.::...  :....|.|.        .:|||        
  Fly  1580 -IKH------QNSNHYQNGAYNIDPTGPNNMAH--AKNNAYSTM--------GRRGNTFGDVGLL 1627

  Fly  2110 --NTEVLCPRHAKAHLELRQPNTDSSDTYEDSLKTDEPLVAHNCRSANCEHRQHQQHPSHHPHY- 2171
              |.|::       :..|.:....::..|...:....||              .|:..|.|.|. 
  Fly  1628 NGNGELM-------NATLGRNGQLNNRLYGGEVPITNPL--------------FQRSNSDHNHLS 1671

  Fly  2172 ---QNTRFEKRSCVRHSFSGVKD 2191
               :|..|.||...:..||.:.|
  Fly  1672 STNENVSFGKRDYGQIGFSYLND 1694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 41/122 (34%)
Cadherin_repeat 325..407 CDD:206637 22/95 (23%)
Cadherin_repeat 416..524 CDD:206637 27/133 (20%)
Cadherin_repeat 534..626 CDD:206637 26/97 (27%)
Cadherin_repeat 641..>714 CDD:206637 6/72 (8%)
CA 851..925 CDD:214520 21/73 (29%)
CA 1026..1085 CDD:214520 12/58 (21%)
Cadherin_repeat 1177..1280 CDD:206637 18/106 (17%)
Cadherin_repeat 1289..1385 CDD:206637 13/95 (14%)
Cadherin_repeat 1414..1510 CDD:206637 28/95 (29%)
CA 1576..1658 CDD:214520 19/81 (23%)
Cadherin_repeat 1666..1760 CDD:206637 24/105 (23%)
Cad99CNP_001189311.1 Cadherin_repeat <68..138 CDD:206637 13/45 (29%)
Cadherin_repeat 146..259 CDD:206637 41/122 (34%)
Cadherin_repeat 280..383 CDD:206637 26/120 (22%)
Cadherin_repeat 393..496 CDD:206637 27/132 (20%)
Cadherin_repeat 518..594 CDD:206637 24/93 (26%)
Cadherin_repeat 608..699 CDD:206637 31/214 (14%)
Cadherin_repeat 710..802 CDD:206637 35/151 (23%)
Cadherin_repeat 814..903 CDD:206637 33/287 (11%)
Cadherin_repeat 915..1005 CDD:206637 30/112 (27%)
Cadherin_repeat 1041..1144 CDD:206637 30/143 (21%)
Cadherin_repeat 1159..1264 CDD:206637 25/110 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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