Protein Alignment Cad89D and Cad86C

DIOPT Version :10

• Sequence 1: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Sequence 2: NP_001247033.1
• Gene: Cad86C / 41302
• FlyBaseID: FBgn0261053
• Length: 1949
• Species: Drosophila melanogaster
• Alignment Length: 2430
• Identity: 456/2430 - (18%)
• Similarity: 731/2430 - (30%)
• Gaps: 913/2430 - (37%)

  Fly    73 VRFIRLREDAQVGKEILRLQA------YPRSTAALKGADASGDHKYFNLTEHNATTLVVSLARSL 131
            :|.:.:..||||...|.||:|      ||.:...:..|.||             |..|.||.
  Fly   148 MRLVLVPADAQVNSVIYRLRATDEEFDYPLTFEFVGDASAS-------------TVKVESLP--- 196

  Fly   132 ERLVDRDVPRNLLKFRILCAGK---QEKLEEGSYLSITVYIED--------------VNDNAPE- 178
                       ..|:..:|...   |.:||.|.|....|.::|              .|...|.
  Fly   197 -----------CTKYNSVCQANIVLQRRLEPGRYYDFQVSVKDTKGGMTTQLCSITATNFTTPHD 250

  Fly   179 --FLNVPYVV----DVDENTSIESIIFEGVQAFDRDKPNTPNSEVHFSMSTVPEQLSADGSPYFA 237
              |.:.|.::    |....|.::.:|......|.:                 |..|...|||.||
  Fly   251 LIFPHKPGIIMIPEDAKRGTELDYVIARKNPLFQK-----------------PVYLELWGSPLFA 298

  Fly   238 LK------SPHRPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQ-----ANTTITINVRDVDDL 291
            ::      ......:.|...|||:.. ..:.|.|.|.|......|     |...|.:.|:||.|.
  Fly   299 IRQKIVSSETTEGTVFLLGPLDFEKQ-AMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQ 362

  Fly   292 PPKFTEGVYRTRINEFYPMTGVPIRIPLYFAPPIM---------AFDQDSLNASLV-YDIISGNE 346
            ||.||...         |:|.:|        |.|:         |.|.|..|...| |.::|.|.
  Fly   363 PPVFTSAP---------PVTKLP--------PGILPGDKILQVHAEDGDKGNPREVRYGLVSENN 410

  Fly   347 --RQLFRVNPHNGVMYLQKEI-DLEEESLPGNTFVLQLEARQ----KDNPLKKALA---RIEVEV 401
              ...|.:|..:|.::|.:.: |:...:..|:..:|.:.|.:    :|.|  .|||   ::...:
  Fly   411 PFTSFFDINETSGEIFLMRPLEDIAFITHVGDPVLLTVIAEEVKVGRDEP--PALASTVQLAFFL 473

  Fly   402 LDLNDNVPEFEADYYNISIVENLPTGFSVLQVN-----AVDRDQGENSEFLYNLVETKDAAGAFR 461
            .|..::.|.||.|:|...:.||.|.|.::..|:     ..|.|.|:|..|...|:...   |.|.
  Fly   474 PDRTNSPPYFENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNN---GTFE 535

  Fly   462 I-----DSRTGW-ITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLD 520
            |     :...|: |.|||:.:||.||::|:|..:.|.|..|:    .:|.    :.|.|.:.:.|
  Fly   536 ISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQELGPA----TNLS----ALVNVTVYIND 592

  Fly   521 TNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYI--PFRLDN 583
            .|||.|.||. ..|..::|.|...|..:.||:|.|||.|..|.:.|...    .||:  ...||.
  Fly   593 VNDNAPVFEQ-PAYSVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAI----LGYLNTSLNLDA 652

  Fly   584 KNGTIYVGGPLRRGRIAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGA 648
            :.|.|.|.                  ||  :..|...|:                 ..|..:|.|
  Fly   653 ETGLITVS------------------TN--KHGFDREVM-----------------PEYHLYVEA 680

  Fly   649 NTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAV 713
            ....|            ||.           ...||..|:    :|.|..|...|.:.:|:|
  Fly   681 RDMDG------------EGN-----------RAQVPLIIK----LIDVNDETPIFDKDLYEF--- 715

  Fly   714 ANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNK----PEQKVPLRPVIEEI 774
                        :::......||.|               .||..:|    |..:|.    .|.|
  Fly   716 ------------ILTHDLMGFTTTA---------------VIHAEDKDATAPNNEVR----YEII 749

  Fly   775 NMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSK 839
            |.|    :..:.|:..:.|:|..:..|:|                                ||.|
  Fly   750 NGN----YDNQFVLDKVTGELTVREKIHL--------------------------------RSKK 778

  Fly   840 SKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYST-- 902
            :.:...||..|                    |..||..:..||.      .:|:|.|.|.:||
  Fly   779 NAKTRRRRQAG--------------------SDDEDTDIFILTA------RAYDLGVPVRFSTTT 817

  Fly   903 -------------------------------GLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLI 936
                                           ..:||..:|..||:....::...|.......|:.
  Fly   818 IRVYPPESRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIHNIRPLSPDEPGAKDIPAGNPGIK 882

  Fly   937 NENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGA 1001
            ..:.|..|.:..:.:::                  |.|     |.....|..|:::..||..|.:
  Fly   883 ERSVVTATVIYDSSSVV------------------DIS-----EIQQRLSHHNNSYAIMPQDTSS 924

  Fly  1002 FNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGG 1066
                  ||.           .|.:||.:|                  .|.:.|:.|.|:.|.
  Fly   925 ------TDT-----------LTPLQTQYK------------------AENKVLFWLLILLAT--- 951

  Fly  1067 LSGYAHLTVLVADVNDNAPMF----ERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAM 1127
            |.....|.:|:..:....|::    :||       :.|.....|:.:...|.::|........|.
  Fly   952 LVALTILILLLCCICSWCPLYGAATKRI-------VNISRTEDDVHLVHREMANGKQTKSVQVAE 1009

  Fly  1128 MLA---------PPPYHI-PGSPRFNVDRER---SVGAGLGV-------VARAKSRRRMVRA--- 1169
            .:.         ||.... |....|:..||:   .||.|..:       :..|:.::|.||.
  Fly  1010 WMGRRDAWSAEKPPDTRTKPTRWEFHDGREQLDEDVGRGQDIGEGDRRHIQSAEEQQRRVRIKHN 1074

  Fly  1170 LTTKCPLFAIYEDTPVGTKVLQLSASDED-FGKNALLHYELQG--EQVERTPGMPMLRVHGVKYF 1231
            .|.|..|...:.::  .|.::    :|.| :.::.:.:.:|.|  |.:.||      ||:..:|.
  Fly  1075 RTAKDDLHLNFHNS--RTNLI----NDRDVYMEDVIENRDLAGDREHITRT------RVNRQEYA 1127

  Fly  1232 AIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPEG 1296
            ...:...|                  |..||   |.:..|..:                   ..|
  Fly  1128 RRKQYDSE------------------VRHID---DDSMRRHEI-------------------DRG 1152

  Fly  1297 EYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVIATD 1361
            .            |:||....|                             .||.|... .|...
  Fly  1153 S------------DIDFNTAHN-----------------------------SLKSKREL-FIKDG 1175

  Fly  1362 NAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPG 1426
            |..::|.|:            .|...:.:..||.                    ..|::...:|.
  Fly  1176 NVEILQLMT------------RDKTRDGLNLDDD--------------------NIYVNVPLKPA 1208

  Fly  1427 TFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIA 1491
            ..:.....:..||.|            :|:....|..:..||  ..|.|       ||..:...|
  Fly  1209 GNLSHPQLLMVDNTG------------KEILMRRFIEEQPDG--KQIIR-------EHYQIVPGA 1252

  Fly  1492 SDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMR-L 1555
            :.:.|         :.|...|..|....:.|..:...|..|:.....|||:....  |::... :
  Fly  1253 TYIQS---------MPNEVQQGSTLKGDTFPLGKSGPNSIVYSQLEPEVKVIHTQ--PVQAGEGV 1306

  Fly  1556 NLSAGLNPENYRWSLW--LEEGLDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLS 1618
            :|...:.|.....||.  ||..|.:           :|.||             .|:.:..::|.
  Fly  1307 SLDQQMQPAVSNQSLTHELEHSLKQ-----------QNALL-------------RQILMEKEKLE 1347

  Fly  1619 REARNYARVSYPVVDERIEGLSL-----NECRILVHIADENDNAPKFRGNGQPIVAVLPQSASFG 1678
            ..   |.:....:..:.:.|.|:     .:|       |.......|.|       ||....|..
  Fly  1348 NA---YTQHEVALETQSLPGQSMAIGTQTDC-------DAGTQTEGFDG-------VLDPEISLA 1395

  Fly  1679 YPVTRVEANDLDEGLNAE----IRYRLLNEPARLFGIDELSGNIRLLGELSRTEHIYGFDVKATD 1739
            .|..|...::.||.::.:    :|:...|.|                      |.:|....:.|.
  Fly  1396 KPSRRRARSENDESMSEDGYEYVRFNPPNSP----------------------EGVYWIKRRRTK 1438

  Fly  1740 RMGADDGRSGIVNVFVYIINEAK-QVRLVVAGMPVEVERRIEG------------------LMEA 1785
            :..... |..||     ::.|.| ::|     .|::.|..::.                  |.:.
  Fly  1439 KRPRQP-RKRIV-----MVEEVKRKIR-----TPIKEEEEVQERKKRVPPKKPLRETKTSILRKQ 1492

  Fly  1786 LSDAIGKDVRVRLLEPYSGGLEPATNAYIYAVDPHTNSI-MEMEQLQDALAGLQLDALQLQQQKL 1849
            |||...|| :.|..|..:|      |.:....|.|...: ||:....|
  Fly  1493 LSDESRKD-QSRNGESQTG------NRHRSESDSHNRDMFMEITDSMD----------------- 1533

  Fly  1850 DGGKPMPRILELAEFGQLARPAHASASSFMGGLEFVTVVLLALISLGALIAACCYVCMRQKRRLW 1914
                            :||.|...|       :..:.|                     :|....
  Fly  1534 ----------------ELASPGSHS-------IRKIQV---------------------EKYYKH 1554

  Fly  1915 SQRDFSASDAGLTYTIAGIGS---------PRGQKQRRQRQQRHT-------------------- 1950
            |..||...|.  .|:|...|.         .|.|:..|.|:|..|
  Fly  1555 SDGDFDEDDT--EYSIDSDGDEIVIRTNYPSRAQENERYRRQERTYAEPENPVDRKRPARKSSPT 1617

  Fly  1951 ----------QRCSKGSTGSQRPTSAFMPESVCSSAQTQSTATATEKLEQQLHHHHQQQAMATQQ 2005
                      .|......||::.||:..|.:..|.::.:||.|           .:.::.|:|..
  Fly  1618 DSQPEAMPRLSRRDSSKRGSRKQTSSEPPHNRVSISKYESTVT-----------ENGRKLMSTST 1671

  Fly  2006 Q---HHQYLNEQQRQQKREYIDVP-----LPKSIA----KAAAVTSGGDGAVGVGSTPFVLKYNA 2058
            :   ..:.|.::..|.:.|...:.     :||.:.    |..:..||........|.|...|
  Fly  1672 EIVGSKRSLTDRSYQSETELAGLEHEERNVPKYMEWYYNKKKSSVSGRTSTESSKSQPSSKK--- 1733

  Fly  2059 CQPVNNLNNYETSLFSLHSTGQDSGVE---FLSSRELYETSPDSFQHGGSKRGNNTEVLCPRHAK 2120
                 .:...|..:.....|.|...||   ....|...|.:|......||:.......|..:| |
  Fly  1734 -----KVGAAEKRVSKTRITAQPKDVEEYDETGGRYKPEPAPRKSPPKGSRLLKEDRALNKQH-K 1792

  Fly  2121 AHLELRQPNTDSSDTYEDSLKTDEPLVAHNCRSANCEHRQHQQH-------PSHHPHYQNTRFEK 2178
            ..:|     ||          |:.||:.|:      |||..:::       |:..|||.......
  Fly  1793 PKIE-----TD----------TNHPLLQHS------EHRFERENALEVPAAPTKLPHYMYPETPP 1836

  Fly  2179 RSCV--RHSFSG-----VKDDLMQQSP-------------QISLRPRGHALRNSMN--------D 2215
            .:..  :.|.||     .|:...:.||             .:..|..||..:..:|        |
  Fly  1837 HAAAGGKESKSGRESKTSKEAKPKPSPIRENEVKVSNSKIYVEHRGTGHPTQKQLNASTLEDDHD 1901

  Fly  2216 LEQRLHNLEQSFRRPLEFSKSNSLF 2240
            ....:::|..|..|....::..|:|
  Fly  1902 SGIAMNSLLNSLGRRNPIAEKKSVF 1926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	26/121 (21%)
		Cadherin_repeat	325..407	CDD:206637	23/101 (23%)
		Cadherin_repeat	416..524	CDD:206637	34/118 (29%)
		Cadherin_repeat	534..626	CDD:206637	24/93 (26%)
		Cadherin_repeat	641..>714	CDD:206637	15/72 (21%)
		CA	851..925	CDD:214520	16/106 (15%)
		CA	1026..1085	CDD:214520	11/58 (19%)
		Cadherin_repeat	1177..1280	CDD:206637	17/105 (16%)
		Cadherin_repeat	1289..1385	CDD:206637	12/95 (13%)
		Cadherin_repeat	1414..1510	CDD:206637	16/95 (17%)
		CA	1576..1658	CDD:214520	11/86 (13%)
		Cadherin_repeat	1666..1760	CDD:206637	16/97 (16%)
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	25/118 (21%)
		Cadherin_repeat	372..469	CDD:206637	25/106 (24%)
		Cadherin_repeat	487..596	CDD:206637	34/119 (29%)
		Cadherin_repeat	605..703	CDD:206637	35/165 (21%)
		Cadherin_repeat	728..820	CDD:206637	32/172 (19%)
		PTZ00449	<1428..1918	CDD:185628	108/611 (18%)