DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and cdh23

DIOPT Version :10

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_999974.1 Gene:cdh23 / 407978 ZFINID:ZDB-GENE-040513-7 Length:3366 Species:Danio rerio


Alignment Length:2135 Identity:528/2135 - (24%)
Similarity:818/2135 - (38%) Gaps:535/2135 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 SYLSITVYIE--DVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNSEVHFSMST 223
            |..|.||::.  |:|||.|.|||:|:|.:|.|...|.|.:|. ||..|.|:              
Zfish   874 SSASATVFVNLLDLNDNDPAFLNLPFVAEVPEGLPIGSSVFR-VQVQDPDE-------------- 923

  Fly   224 VPEQLSADGSPYFALKSPHRPL--------------LILKRELDFDNGIRQFKLPIFAWDRGTPA 274
                 :|:|:...||:.....|              ::|.||     .|.|:.|.|.|:|.|...
Zfish   924 -----AANGAVTMALQMGMPRLDFRLNITTGILVSTVVLDRE-----QIGQYYLRIIAYDAGQFP 978

  Fly   275 NQANTTITINVRDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQDS-LNASLV 338
            ..:.:|:||.|.||:|..|.|...||...:.|..|...:.:|        :...|.|: |||.|.
Zfish   979 RTSTSTLTITVLDVNDETPTFFPSVYNVSLEESVPRDYLVVR--------LNCTDNDAGLNAELS 1035

  Fly   339 YDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDN-PL---KKALARIEV 399
            |.|.:||:...|.|....||:.....:|.|.::    ::.|.:||  .|| |.   :...|.:.|
Zfish  1036 YFITAGNQDGKFSVGFRTGVVRTVVGLDRETQA----SYRLVIEA--IDNGPAGGRRTGTATVYV 1094

  Fly   400 EVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDS 464
            ||||:|||.|.|..:.|..|::||:|.|.|:|||.|.|.|||||.:.||.::...:  |.|.:||
Zfish  1095 EVLDVNDNRPIFLQNSYETSVLENIPRGTSILQVQATDADQGENGKVLYRILSGNN--GQFSMDS 1157

  Fly   465 RTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLDTNDNTPKFE 529
            .:|.|: |....||||.|.|..|.|||      |..|....:   |.|:|.:.:.|.||..|.|.
Zfish  1158 LSGLIS-RGSVALDRETRSSNVLEVEA------YNSDLGSMR---STVRVIVYVEDVNDEFPVFT 1212

  Fly   530 HGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNGTI----YV 590
            ........:...|..|..:..|.|.|||.|..|.:.|.|  ..||.. .|.:|...|.:    |:
Zfish  1213 QSQYNRLGLRETAGIGTSVVVVRATDPDTGDGGAVAYSL--VSGSDR-KFEVDVSTGLLTTVDYL 1274

  Fly   591 GGPLRRGRIAVFVEATDQPTNPSERRFSLAVITI--EVYATIDDQAIDFVGAPYEFWVGANTPLG 653
            ....:...: :.|.|||| :.|..|.:....:|:  |:     |:|:.|:.|.||..:..|...|
Zfish  1275 DYETKTSYL-MNVSATDQ-SPPFHRSYCTVYVTLLNEL-----DEAVAFLSAGYEVSLRENIATG 1332

  Fly   654 TSVGQVRTTLIYEGGDEIMYDLLHTYSEGVP------FAIEERSGIITVIRELSEFKRKVYQFEA 712
            |.|.||:.    :..|. :..|.:.:.....      |.|:..:|.|||...|...:...|....
Zfish  1333 TEVVQVKA----QSADN-LNQLSYRFDPDTSPAALALFKIDSVTGRITVTGLLDRERGDSYTLTV 1392

  Fly   713 VANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRPVI------ 771
            ||:........::.:|      .||....:.|.|..:.::|:::|   ||.....:.|.      
Zfish  1393 VADDGGPKRGSTVKVS------ITILDENDNSPEFDITSDLSVNI---PEDTAIGKRVAVVLARD 1448

  Fly   772 EEINMN-VIHFHVEENVVGGIIGQLLYKNGINLVNNELG-TYREMPSEPTSRNITMGSRFRSRNR 834
            ::...| :::|.:   :.|.:  |.::|  ||.|||..| .|...|.:..|.:     |:..:.|
Zfish  1449 KDAGRNGLVNFTL---IAGNM--QDVFK--INTVNNTYGEVYLNAPLDRESVD-----RYLLKVR 1501

  Fly   835 SRSSKSKRRL---------------------PR-------RLVGDANIKLR-------------- 857
            :..:.|..|.                     ||       ..||.....||              
Zfish  1502 AMDNGSPPRYTDVSLTVNIVDVNDNPPVLQSPRGYNVSVSENVGGGTSVLRVVATDRDIGANAML 1566

  Fly   858 --YIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDV 920
              ||.|..|::..::.......:...:..|||:|..|.|||.|| ..|..:.:....|.:::.|.
Zfish  1567 SYYITAGNQDLTFRMDRMTGEIVTRPSPPDREKQQQYTLTVTVE-DDGTPTLSTSTTVWVRIIDE 1630

  Fly   921 NDNAPKFNALTYVGLINEN-CVVGTELSMNHAILIQDADEGPNAEFRVQL-QGDYSDEFSIEYVN 983
            |||||:|....||..:.|. ..||..::...||   |.|||.|...|..: :|:.:..|.|..|.
Zfish  1631 NDNAPEFPEEEYVTELREGPNTVGAIIATVTAI---DPDEGLNGTIRYAISKGNLAQTFQINSVT 1692

  Fly   984 G-------TSSENSTHHKM-----------------PSTTGAFNIFNLTDQ-------WNDEFKY 1017
            |       ...|.|..|.:                 .|||...|:.::.|.       :...|:.
Zfish  1693 GQIVVVSALDYEISNGHYVLTVTATDQCPIPLLRLTSSTTVLVNVIDVNDNPPIFPRPFEGPFEI 1757

  Fly  1018 QELHT-----TFMQTNFKLSSGPYFRISYTGKRG----------------------LDREKQQLY 1055
            .|...     |...|:  ..||...::.|:...|                      ||||....|
Zfish  1758 TEGQPGPRVWTVKATD--ADSGSNGKVEYSITAGDLKNEFVISSVEGELRVRKDIELDRETIAYY 1820

  Fly  1056 NLKIIAADTG--GLSGYAHLTVLVADVNDNAPMFERI----SVFKDSRLEIREYTTDMEIYFVES 1114
            |:.|.|.|.|  .|:....:.:||.|:|||.|:...:    ||.:.:.::    |..:::...:|
Zfish  1821 NITITAKDLGTPSLNATVVVGILVLDINDNDPILLNLPANTSVSEGAAVQ----TFIIQVRAQDS 1881

  Fly  1115 SSG--------MTAPQATAAMMLAPPPYHIPGSPRFN--VDRERSVGAGLGV----------VAR 1159
            .||        :||..:..|..:    ....|..:.|  :||||.....|.:          :||
Zfish  1882 DSGRNALLTYSITAGNSDGAFYI----NETSGVVQVNRPLDRERVAEYSLTITVKDNPDNPRIAR 1942

  Fly  1160 AKSRRRMVRAL--TTKCPLFA-------IYEDTPVGTKVLQLS----ASDEDFGKNALLHYELQG 1211
            ..|....|..|  ....|:|:       |.|::|.||.||.|:    |.|:|.|.||::.|.|.|
Zfish  1943 RDSELLTVTLLDVNDNRPIFSQSSYRGEISENSPTGTTVLILNGPVLAEDKDIGVNAVVSYGLLG 2007

  Fly  1212 EQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIE------IMLNLTVTDIDGLKDSTCL 1270
            .:|:              .|:||..:|.:||......:.|      :.|.|...|:.||..|..|
Zfish  2008 TRVD--------------IFSIDSRTGVVSVRGGAVLDREAFSVPRVELFLVSVDVGGLNSSVPL 2058

  Fly  1271 RFTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTL-SDSHLPFTIKP 1334
            ..|::|||::.|.|..|.::...||......|:.||:|.|.|.|.|..:.|.| |.:...|.:..
Zfish  2059 TITILDVNDNPPVFNPSSFTVRLPENSPTGVVVTQLSATDADAGSNGWLQYRLDSGAQDRFIVDA 2123

  Fly  1335 ASGVLKIG-GQLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFI-------- 1390
            .||.:.:| ..||||.:..|...|||||..  ...:|.:..:.|.:.|:||:||.||        
Zfish  2124 LSGAVLVGNATLDREERSSYRLVVIATDRG--TPSLSGTATLTVVLDDVNDSRPRFIQPVQTISV 2186

  Fly  1391 ------------------------------------------------GYDDQTKAV-------- 1399
                                                            |.|..|.||        
Zfish  2187 NESTPPGVVVATLAAEDPDLKPRLEYYIISVEAKDDGNNAVDGLQQSFGIDFHTGAVFVRNPLNR 2251

  Fly  1400 ------KFIPSVADR-------TLMLPVYKAYLD------------------------RSTQPGT 1427
                  :.|.||.|.       ::.:|..|..::                        ....|||
Zfish  2252 ELVATFEIIVSVHDNASDVIEMSVSVPNAKLTINVLDVNDNAPRFRPFGVANFSESILEGAVPGT 2316

  Fly  1428 FVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIAS 1492
            .:..:||:|.|.  ..||.::|.:.:......:...|...|.| ..:|...:...:.||.:|.|.
Zfish  2317 TLLSVTAVDPDK--GPNGQIIYQLLNLPRGNYIRLEDPSTGKI-VANRTVDFEQVQWLNFTVRAQ 2378

  Fly  1493 DVGSPALSATAIVIVNLQGQAVTDPPKSTPKP------EPPANVTVFQHAYYEVKLTEN---NEA 1548
            |.||                    ||:.|..|      :...|..|||...|:..:.|:   ...
Zfish  2379 DHGS--------------------PPRFTELPVYLRIIDVNDNNPVFQQPLYQKSIFEDVALGTI 2423

  Fly  1549 PIEVMRLNLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIR 1613
            .:.|...:..:||      :|: :|.||  .|....|........:|.|...|||...||.|.. 
Zfish  2424 IVSVRATDADSGL------FSV-IEYGL--VDGEGKFGITPTTGDIYILSALDRETKDRYTLTA- 2478

  Fly  1614 ADRLSREARNYARVS---YPVVDERIEGLSLNECRILVHIADENDNAPKFRGNGQPIVAVLPQSA 1675
                      |||.:   .|  :.|.|    |..::.:.:.|.||..|:|  :.:.....:.::.
Zfish  2479 ----------YARDNPGGSP--NNRRE----NSVQVQLTVLDVNDFRPRF--SERVFTTSVFENE 2525

  Fly  1676 SFGYPVTRVEANDLDEGLNAEIRYRLLNEPARLFGIDELSGNIRLLGELSRTEHIYGFDVKATDR 1740
            ..|..|..::|.|||||.||.:.|.|....|..|.:|..:|.||.|..|...|. :...|.|||:
Zfish  2526 PVGTSVITMKATDLDEGENALLTYSLQGPGADAFSLDPDTGLIRSLRLLQSFER-FNLTVVATDQ 2589

  Fly  1741 MGADDGR-----SGIVNVFVYIINEAKQVRLVVAGMPVE--VERRIEGLM--EALS----DAIGK 1792
                 ||     :..:.:.|..:|:.:.:.:..|...:.  :|.:..||:  |..:    :.:..
Zfish  2590 -----GRPPLWGTASLQITVIDVNDNRPIFVRPANGTIMHILEEQPPGLVVYEVFATDEDEGVNG 2649

  Fly  1793 DVRVRLLEPYSGGLEPATNAYIYAVDPHTNSIMEMEQLQDALAGL--------------QLDALQ 1843
            :||...|:..:|..: ..|.:|.||.....:.:::::.:.||..|              .:..||
Zfish  2650 EVRYSFLQTGAGNRD-WENFHIDAVTGVITTAVKLDREKQALYSLVVVAYDLGQPVPYETMQPLQ 2713

  Fly  1844 LQQQKLDGGKPM----PRILELAEFGQLARPAHASASSFMG----------GLEFVTVVLLALIS 1894
            :....:|..:|:    ||  ....:..|:.|.|:|..:.:|          |...:....:|...
Zfish  2714 VALSDIDDNEPVFLKPPR--GSLPYQSLSVPEHSSPGTVVGNVTGAVDADEGSNAIVYYFIAGGD 2776

  Fly  1895 LGALIAACCYVCMRQKRRLWSQRDFSASDAGLTYTIAGIGS------PRGQKQRR 1943
            .|...|......:|.|      :|....:..:...|....|      |:||:.:|
Zfish  2777 TGGNFALSVSGVLRVK------KDLDREEIPVYSIIVKASSNRNWTPPKGQRSQR 2825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 32/120 (27%)
Cadherin_repeat 325..407 CDD:206637 29/86 (34%)
Cadherin_repeat 416..524 CDD:206637 43/107 (40%)
Cadherin_repeat 534..626 CDD:206637 25/97 (26%)
Cadherin_repeat 641..>714 CDD:206637 18/78 (23%)
CA 851..925 CDD:214520 22/89 (25%)
CA 1026..1085 CDD:214520 22/82 (27%)
Cadherin_repeat 1177..1280 CDD:206637 37/119 (31%)
Cadherin_repeat 1289..1385 CDD:206637 31/97 (32%)
Cadherin_repeat 1414..1510 CDD:206637 22/119 (18%)
CA 1576..1658 CDD:214520 21/84 (25%)
Cadherin_repeat 1666..1760 CDD:206637 28/98 (29%)
cdh23NP_999974.1 Cadherin_repeat 48..134 CDD:206637
Cadherin_repeat 142..237 CDD:206637
Cadherin_repeat 246..350 CDD:206637
Cadherin_repeat 358..460 CDD:206637
Cadherin_repeat 469..561 CDD:206637
Cadherin_repeat 570..671 CDD:206637
Cadherin_repeat 679..778 CDD:206637
Cadherin_repeat 786..890 CDD:206637 6/15 (40%)
Cadherin_repeat 898..994 CDD:206637 32/120 (27%)
Cadherin_repeat 1003..1102 CDD:206637 34/112 (30%)
Cadherin_repeat 1110..1206 CDD:206637 42/107 (39%)
Cadherin_repeat 1221..1311 CDD:206637 26/99 (26%)
Cadherin_repeat 1321..1417 CDD:206637 23/106 (22%)
Cadherin_repeat 1428..1526 CDD:206637 22/112 (20%)
Cadherin_repeat 1536..1633 CDD:206637 22/97 (23%)
Cadherin_repeat 1641..1743 CDD:206637 25/104 (24%)
Cadherin_repeat 1755..1850 CDD:206637 23/96 (24%)
Cadherin_repeat 1858..1958 CDD:206637 21/107 (20%)
Cadherin_repeat 1966..2068 CDD:206637 36/115 (31%)
Cadherin_repeat 2076..2172 CDD:206637 30/97 (31%)
Cadherin_repeat 2181..2292 CDD:206637 11/110 (10%)
Cadherin_repeat 2304..2401 CDD:206637 25/119 (21%)
Cadherin_repeat 2410..2507 CDD:206637 27/122 (22%)
Cadherin_repeat 2516..2610 CDD:206637 29/99 (29%)
Cadherin_repeat 2624..2722 CDD:206637 18/98 (18%)
Cadherin_repeat 2738..2849 CDD:206637 18/94 (19%)
Cadherin_repeat 2858..2959 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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