DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and pcdh15a

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:XP_009305800.1 Gene:pcdh15a / 368476 ZFINID:ZDB-GENE-030616-3 Length:1806 Species:Danio rerio


Alignment Length:2206 Identity:466/2206 - (21%)
Similarity:721/2206 - (32%) Gaps:833/2206 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 SLERLVDRDVPRNL--LKFRILCAGKQEKLEEGSYL--SITVYIEDVNDNAPEFLNVPYVVDVDE 190
            |..|::|||.|.::  :..:|.|..:.    .|:.:  .:.:.:.|.|||.|.|....|.|.|:|
Zfish   103 STGRVLDRDPPSSITTIVVQIQCTNEL----VGTVILHEVRIVVRDRNDNTPRFQQPRYYVSVNE 163

  Fly   191 NTSIESIIFEGVQ----AFDRDKPNTPNSEVHFSMSTVPEQLSADGSPYFALKSPHRPL------ 245
            .|.:.:.||.|..    |.|.|  :.||.::.:::.                .:|:.|:      
Zfish   164 LTPVGTTIFTGFSGNNGATDID--DGPNGQIEYAIQ----------------YNPNDPMSNRTVR 210

  Fly   246 --------LILKRELDFDNGIRQFKLPIFAWDR----GTPANQANTTITINVRDVDDLPPKFTEG 298
                    ::|...|:::...| :.:.:.|.||    || ...|.||:|::|.|.|||.|.|...
Zfish   211 IAGTLSGNIVLAERLNYEERTR-YLIIVQANDRAPYPGT-RRTATTTLTLDVLDGDDLGPMFLPC 273

  Fly   299 VYRTRINEFYPMT---GVPIRI------PLYFAPPIMAFDQD------SLNASLVYDIISGNER- 347
            |......:..|:|   .:|...      ||...|||.|.|||      |....::|.|:.|... 
Zfish   274 VLVNNTQDCNPVTYRVAIPELTDPNKLNPLNVTPPIRAIDQDRNIQPPSDRPGILYFILVGTPST 338

  Fly   348 --QLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPE 410
              :.|.:|.....:.|.|.:|.|..    ..|.|.::|.|.:.....|.:::|:|:||.|:..|.
Zfish   339 YPEFFTLNRSTAELRLLKSVDRELY----QRFSLVIKAEQDNGHPLPAYSKLEIEILDENNQAPY 399

  Fly   411 FEADYYNISIVENLPTGFSV---------LQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRT 466
            |:...|...:.|:...|.::         |.:.|:|.|          :.||||......::..|
Zfish   400 FQQSSYRGFVSESSSVGTTISASANLTAPLAIIALDND----------IEETKDPQLKITLNEYT 454

  Fly   467 GWITVRDDRL---------LDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLDTN 522
            ...|:....:         :|||.:.:..|.:.|       .|.....:|    |.|:|.::|.|
Zfish   455 SIFTITTSGITRFLTLLKPVDREIQTNYTLTLVA-------TDGVQQSRP----VTVDILVIDAN 508

  Fly   523 DNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNG- 586
            ||||.|...: |..::..|...|..:.|::|.|.|.|.||.:.|.:.......:|   ::|:.| 
Zfish   509 DNTPTFAQVS-YSVEIFTNMLPGETVLQLMAQDADAGLNGLITYAILAGDHGDFI---INNRTGR 569

  Fly   587 -TIYVGGPLRRGR-IAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGAN 649
             |:..|..|..|| .|:.|.|.|...: :|||.|:..:.|||....:.       :|..|     
Zfish   570 ITLAPGVMLTVGRSYALTVRAADNAPD-TERRSSITTVYIEVLPPNNQ-------SPPRF----- 621

  Fly   650 TPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAVA 714
             ||.|                  |:|                       |:||..|         
Zfish   622 -PLQT------------------YNL-----------------------EISEAMR--------- 635

  Fly   715 NYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRPVIEEINMNVI 779
                                                                             
Zfish   636 ----------------------------------------------------------------- 635

  Fly   780 HFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRL 844
                        ||.:|    :||    ..|.||:  :|.:..|..|                  
Zfish   636 ------------IGAIL----LNL----QATDREL--DPITYRIETG------------------ 660

  Fly   845 PRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAG 909
                             :.|||.| :|.| .|.||....||||....|.|  ||..|.|...|..
Zfish   661 -----------------DPQEVFN-LSRT-IGLLLLAKPLDRETIDQYRL--IVTASDGHPGGIS 704

  Fly   910 IYQVNIKVDDVNDNAPKFNALTYVGL-INE---NCVVGTELSMNHAILIQDADEGPNAEFRVQLQ 970
            ...|:|.:.|||||.|.|:......| :.|   |..||       .:...|.|.|.|.:.|.:|.
Zfish   705 TATVSIVITDVNDNDPTFDLTLPRNLTVREEEANVFVG-------QVRATDPDGGLNGQVRYRLL 762

  Fly   971 GDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGP 1035
             .::..|||   |.|.|                ||....                          
Zfish   763 -SFASLFSI---NSTGS----------------IFTAVP-------------------------- 781

  Fly  1036 YFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVL--VADVNDNAPMFERISVFKDSRL 1098
                       ||||.:..|:|.:.|:|.........:|:|  |.|:|||:|:|.:         
Zfish   782 -----------LDRETRSRYDLIVEASDGAVDPRRTTITLLVEVLDINDNSPVFSQ--------- 826

  Fly  1099 EIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKSR 1163
                                             |.|                             
Zfish   827 ---------------------------------PVY----------------------------- 829

  Fly  1164 RRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPMLRVHGV 1228
                   |...|     |:||.|:.:|:|:|.|.|...|  :.|.::.|.             .:
Zfish   830 -------TVNVP-----ENTPAGSIILRLTAVDADLVSN--VTYRIKTEA-------------AL 867

  Fly  1229 KYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFDT 1293
            :.||:::|:|.:||                                                   
Zfish   868 QLFAVNRLTGVISV--------------------------------------------------- 881

  Fly  1294 PEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVI 1358
                        |.|:|.:.....|.|||                                |:|.
Zfish   882 ------------LQALDFESLAAGNSTYT--------------------------------FEVE 902

  Fly  1359 ATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRST 1423
            |.|:..|:.  ..:..|.|.:.|:||..|.|                     ...:||..:..:.
Zfish   903 ALDHGGVLP--PGTATVSVRITDMNDFSPVF---------------------RQALYKGLVAPNA 944

  Fly  1424 QPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEM---QAPLFQIDSRDGTISTISRINGYNDYEHL 1485
            :.||.:..:.|.|:|..|.....|.|.: .||:   ...:|.:::..|.:  |:::|       |
Zfish   945 EKGTVITTVLAEDQDPPGTPASKVRYRV-DQELSPYSGSIFDVETDTGLV--ITKVN-------L 999

  Fly  1486 N--------VSVIASDVGSPA-LSATAIVIVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYYEVK 1541
            |        :.|:|.|.|.|. .:.|.:.|..||                |:.:.:|....|...
Zfish  1000 NEQPTTVFKLVVMAYDDGEPVKTNRTTVEITVLQ----------------PSRIPIFTEEEYRFS 1048

  Fly  1542 LTENNEAPIEV-MRLNLSAGLNPE-NYRWSLWLEEGLDETDAHPPFEYDAKNMLLYALKPFDREH 1604
            ....| |||.. :.|.|:|..|.. .|......|.|:        |..:....::|..|..|.|:
Zfish  1049 PVSEN-APIGTPVGLILAAATNTTVVYSIVSGNEGGV--------FTVNKSTGIIYTNKSLDYEN 1104

  Fly  1605 ISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAPKFRGNGQPIVA 1669
            ::.|.||::||.|:....|....|           ..|..::.:::.||||:.|.|  :.|..:.
Zfish  1105 VTSYVLRVQADSLTVILANLRAPS-----------KTNTAKVFINVQDENDHPPVF--SRQVYIG 1156

  Fly  1670 VLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPAR----LFGIDELSGNIR---LLGELSRT 1727
            .:.:.......|.::.|.|:|.|..:::.|||:..|..    .|.|:..:|.|:   :...:.|:
Zfish  1157 GVTEDTKTFTTVLKIVATDVDTGNYSKMAYRLIIPPTTEGQDSFVIEPYTGVIKSAIMFRNMRRS 1221

  Fly  1728 EHIYGFDVKATDRMGADDGRSGIVNVFVYIINEAKQVRLVVAGMPVEV-----ERRIEGLMEALS 1787
              .:.|.|.|||..|  .|.:...:|.|.::| |..:::||:.:|..|     |:.|..|...:.
Zfish  1222 --YFKFQVVATDDYG--KGLTSKADVVVSVVN-ALDMQVVVSNVPPTVVEENKEQLISILERYVQ 1281

  Fly  1788 DAI-GKDVRVRLLEPYSGG----LE--PATNAYIYAVDPHTNSIMEMEQLQDALAGLQLDALQLQ 1845
            |.| |..|.|..:.|...|    ||  ..::..:||:||.||..:..::|...|.|..||..:..
Zfish  1282 DQIPGAKVIVESIGPRRHGEGYELEDYSKSDLQVYAIDPLTNRAISRQELFKFLDGKILDINKEF 1346

  Fly  1846 QQKL-DGGKPMPRILELAEFGQLARPAHAS-ASSFMGGLEFVTVVLLALISLGALIAACC----Y 1904
            |..| :||    ||||:.....:|....|: |..:..|         ||::|..:|..||    .
Zfish  1347 QPYLGEGG----RILEIRSPDIVATVKKAAQAVGYTEG---------ALLALAIIIILCCIPAIL 1398

  Fly  1905 VCMRQKRRLWSQRDFSASDAGLTYTIAGIGSPRGQKQRRQRQQRHTQRCSK-------------- 1955
            :.|                  :||           ||.::||    ..|:|              
Zfish  1399 IVM------------------VTY-----------KQFKERQ----AECAKTARIQMALPAGKST 1430

  Fly  1956 ---------GSTGSQRPTSAFMP----------ESVCS--SAQTQSTATATEKLEQQLHHHHQQQ 1999
                     |..|....|:.:..          .||.|  ..|.:..:...|...|.|..:...:
Zfish  1431 GGGGGGGGGGGGGGGAQTNLYEELGDGGIHSHLLSVFSRLGLQRRRRSVIEEADRQSLIRNFASR 1495

  Fly  2000 AMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVTSGGDGAVGVGSTPFVLKYNACQPVNN 2064
            |:|.   |.|.....|.:.|       ||||   .:|:|...|........|......:..|..|
Zfish  1496 AIAA---HKQTTGNGQMRSK-------LPKS---ESAITFLSDERPLTTQNPIFQDGLSSSPEPN 1547

  Fly  2065 LNNYETSLF---------------------------SLHST-------------GQDSGVEFLSS 2089
            |.....|.|                           ..:||             .|....|...|
Zfish  1548 LEVRRISGFLYSDPPSPTSPCGQFTSWSLPSRIRGRGFYSTLRRQALWDPAQWEEQQLKAELTDS 1612

  Fly  2090 RELYETSPDSFQHGGSKRGNNTEV-LCPRHAKAHLELRQPNT--DSSDTYEDSLKTDEPLV 2147
            ||  |...|       :.|.:||. |..|......|.....|  .|.|:|. ||..|:||:
Zfish  1613 RE--ELDAD-------QSGRSTETKLSVREQARQFEALADRTPRQSRDSYA-SLDPDDPLL 1663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 29/128 (23%)
Cadherin_repeat 325..407 CDD:206637 25/90 (28%)
Cadherin_repeat 416..524 CDD:206637 25/125 (20%)
Cadherin_repeat 534..626 CDD:206637 28/94 (30%)
Cadherin_repeat 641..>714 CDD:206637 11/72 (15%)
CA 851..925 CDD:214520 27/73 (37%)
CA 1026..1085 CDD:214520 15/60 (25%)
Cadherin_repeat 1177..1280 CDD:206637 18/102 (18%)
Cadherin_repeat 1289..1385 CDD:206637 16/95 (17%)
Cadherin_repeat 1414..1510 CDD:206637 25/107 (23%)
CA 1576..1658 CDD:214520 18/81 (22%)
Cadherin_repeat 1666..1760 CDD:206637 23/100 (23%)
pcdh15aXP_009305800.1 Cadherin_repeat 49..148 CDD:206637 11/48 (23%)
Cadherin_repeat 157..246 CDD:206637 21/107 (20%)
Cadherin_repeat 286..394 CDD:206637 30/111 (27%)
Cadherin_repeat 404..510 CDD:206637 25/126 (20%)
Cadherin_repeat 518..614 CDD:206637 30/100 (30%)
Cadherin_repeat 625..718 CDD:206637 43/268 (16%)
Cadherin_repeat 727..820 CDD:206637 32/156 (21%)
Cadherin_repeat 828..926 CDD:206637 36/250 (14%)
Cadherin_repeat 936..1032 CDD:206637 25/105 (24%)
Cadherin_repeat 1044..1145 CDD:206637 29/120 (24%)
Cadherin_repeat 1153..1252 CDD:206637 25/103 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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