DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and Fat4

DIOPT Version :10

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_899044.3 Gene:Fat4 / 329628 MGIID:3045256 Length:4981 Species:Mus musculus


Alignment Length:2058 Identity:482/2058 - (23%)
Similarity:775/2058 - (37%) Gaps:564/2058 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 IRLREDAQVGKEILRLQAYPRSTAALKGADASGDHKYFNLTEHN---ATTLVVSLARSLERLVDR 137
            :.|.|...|.....::|      |:.|.:.|:|:..| .:|:.|   |..:.......::..:||
Mouse  1003 VTLSESEPVNSRFFKVQ------ASDKDSGANGEIAY-TITDGNNGDAFGIFPDGQLYIKSELDR 1060

  Fly   138 DVPRNLLKFRILCAGKQEKLEE-GSYLSITVYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEG 201
            ::..   ::.:|.......:|. .:.:::||.:||||||.|.|.:..|....:|.....|.:.: 
Mouse  1061 ELQD---RYVLLVVASDRAVEPLSATVNVTVLLEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK- 1121

  Fly   202 VQAFDRDKPNTPNSEVHFSMSTVPEQLSADGSPYFAL-------KSPH---RPLLILKRELDFDN 256
            |.|.|:|  ..||.||.::....        .|.|.|       .|.|   |..|:.:|      
Mouse  1122 VSAVDKD--FGPNGEVRYAFEVT--------QPNFELHAVTGEITSTHKFDRESLMRRR------ 1170

  Fly   257 GIRQFKLPIFAWDRGTP---ANQANTTITINVRDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIP 318
            |...|...:.|.|||.|   .:||  |:.:.::|::|..|||.:..|:..::|........:|  
Mouse  1171 GTAVFSFTVTAMDRGLPQPLKDQA--TVHVYMKDINDNAPKFLKDFYQATVSETATNLTQVLR-- 1231

  Fly   319 LYFAPPIMAFDQDSLNASLV-YDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLE 382
                  :.|.|.|..:..|: |.|:.|||.:.|.::..:|.:.|..::|.|..|    .:.|.::
Mouse  1232 ------VSASDVDEGSNGLIHYSILKGNEERQFAIDSFSGQVTLVGKLDYEATS----AYSLLIQ 1286

  Fly   383 ARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFL 447
            |.........:...:.:::||.|||.|.|......:.::||:..|..|..|.|.|.|.|.|::..
Mouse  1287 AVDSGAIPLNSTCTLSIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGVNADLH 1351

  Fly   448 YNLVETKDAAGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKV 512
            |.:..:.: .|.|.|...||.|.:.  :.||.|.:...:||:.|.::.         :.|..|.:
Mouse  1352 YTITGSNN-HGTFSISPNTGSIFLA--KKLDFETQSLYKLNITAKDQG---------RPPRSSTM 1404

  Fly   513 QVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYEL--QRPKGSG 575
            .|.|.:.|.|||.|.|..|:::: .:..|.|.|..:..|.|||||...||.|.|.:  |.|:|: 
Mouse  1405 SVVIQVRDFNDNPPSFPPGDIFK-SIVENIPLGTSVISVTAHDPDADINGQLSYAIIQQMPRGN- 1467

  Fly   576 YIPFRLDNKNGTIYVGGPLRRGRIAVF---VEATDQPTNPSERRFSLAVITIEVYATIDDQAIDF 637
              .|.:|...||||....:.|....:|   |:|.||......||::|..:||.| ..::|     
Mouse  1468 --HFSIDEVKGTIYTSAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILV-TDLND----- 1524

  Fly   638 VGAPYEFWVGANTPLGTS-----------VGQVRTTLIY----EGGD-EIMYDLLHTYSEGVPFA 686
                       |.|:..|           :|.|.||::.    ||.: |:.|::|:..::  .|.
Mouse  1525 -----------NVPMFISQNALAADPSAMIGSVLTTIMAADPDEGANGEVEYEILNGDTD--TFT 1576

  Fly   687 IEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQS-----LVMSRSSSPLTTIASPAELSDE 746
            ::..||.:.|...|.. .:.:|.....|..|.....:|     :::.....|:.|......:..|
Mouse  1577 VDRYSGDLRVASALVP-SQLIYNLIVSATDLGPERRKSTTELTVILQGLDGPVFTQTKYITILKE 1640

  Fly   747 GVLI-TN-LTIHIVNKPEQKVPLRPVIEEINMNVIHFHVEENVVG---------GII-------- 792
            |..| || ::|...:....:.|       :...::....||..||         |:|        
Mouse  1641 GEPIGTNVISIEAASPRGSEAP-------VEYYIVSVRCEEKTVGRLFTIGRQTGVIQTAAILDR 1698

  Fly   793 --GQLLYKNGINLVNNELGTYREMPSE---------------PT-------SRNITMGSRFRSRN 833
              |..||...:..:.......|...:|               ||       ..||..||:.....
Mouse  1699 EQGACLYLVDVYAIEKSSAFPRTQRAEVEITLQDINDNPPVFPTDTLDLTVEENIGDGSKIMQLT 1763

  Fly   834 RSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIV 898
            ...:.:.           ||..:.|.:.:..:...:|. .|.|.|:....||||.:..|.|  :|
Mouse  1764 AMDADEG-----------ANALVTYALISGADDSFRID-PESGDLIATKRLDREHRSKYSL--LV 1814

  Fly   899 EYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNA 963
            ....||.|..  .::||.:.||||:.|:|:...|...|.|:...|   |:..|||..|.|.|.|.
Mouse  1815 RADDGLQSSD--MRINITISDVNDHTPRFSRPVYSFDIPEDTTPG---SLVAAILATDDDSGVNG 1874

  Fly   964 EFRVQLQGDYSD-EFSIEYVNGTSS-------ENSTHHKM---------PSTT--GAFNIFNLTD 1009
            |....::.|..| .|.:..|.|..:       |...::.:         .|||  ..|||.::.|
Mouse  1875 EISYVVEEDDGDGVFFLNLVTGVFNLTRALDYETQQYYILTVRAEDGGGQSTTIRAYFNILDVND 1939

  Fly  1010 QWNDEFKYQELHTTFMQTNFKLSS------------GPYFRISYT------------GKRG---- 1046
              |........::|.:..|..|.|            |...::||:            .|.|    
Mouse  1940 --NPPVFSMSSYSTSLMENLPLGSTVLVFNVTDADDGVNSQLSYSIASGDSLGQFAVDKHGVLKT 2002

  Fly  1047 ---LDREKQQLYNLKIIAAD-----TGGLSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREY 1103
               ||||.|..|||.|...|     |...:..|.:::::.|||||.|||     .......|.|.
Mouse  2003 LKALDRESQSFYNLVIQVHDLPQPPTSRFTSTAQVSIILLDVNDNPPMF-----LSPKLTYIPEN 2062

  Fly  1104 T-TDMEIYFVESSSGMTAPQATAAMMLAPP------------PYHIPGSPRFNVDRERSVGAGLG 1155
            | .|..::..:::...:.|.:.....|..|            ..|:.|    .:|||......|.
Mouse  2063 TPIDTVVFKAQATDPDSGPNSYIEYTLLNPSGNKFSIGTIDGEVHLTG----ELDREEVSNYSLT 2123

  Fly  1156 VVARAKSRRR---------MVRALTTKCPLFA-------IYEDTPVGTKVLQLSASDEDFGKNAL 1204
            |||..|.:..         ||..:....|:||       |.|:...||.::|:||:|.|.|.|..
Mouse  2124 VVATDKGQPPLSSSTEVVVMVLDINDNNPVFAQAMYRVQIKENILTGTDIIQVSAADNDEGTNGQ 2188

  Fly  1205 LHYELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDID----GLK 1265
            :.|.:.|....:.             |.||.::|.::|...|.........|||...|    ...
Mouse  2189 VRYGIVGGNTHQE-------------FRIDSVTGAITVAKSLDRETTPAYTLTVQATDRGSSPRT 2240

  Fly  1266 DSTCLRFTVMDVNNHAPTFKKSWYSFDTPE------------------------------GEYKD 1300
            ||..:..|::|:|:..|.|:.|.||.:.||                              |..:|
Mouse  2241 DSCTVAITLLDMNDFVPVFELSPYSVNVPENLGTLPRAILQVVARDDDQGPNSQLSYVLLGGNED 2305

  Fly  1301 SVL-----GQL------------------------------------------------------ 1306
            :..     |:|                                                      
Mouse  2306 NAFVLTASGELRVTQSLDREARDHFVLVVTAADAGSPALTGTGTINIIVDDINDNVPTFANNMYL 2370

  Fly  1307 ----------------TAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKYSF 1355
                            .|.|.|...||.|:|::...:..|||.|::|.:.....||||.||.|:.
Mouse  2371 TSIAEDARTGTDVLLVNASDADAAANAVISYSIIGGNSQFTINPSTGQIITSALLDRETKDNYTL 2435

  Fly  1356 QVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLD 1420
            .|:|:| |...:.:|||..|.|.:.|:|||.|.|..:.                     |..::.
Mouse  2436 VVVASD-AGSPESLSSSTSVLVTITDVNDNPPRFQHHP---------------------YVTHIP 2478

  Fly  1421 RSTQPGTFVRQLTAIDKDNVGNGNGLVLYSI--RHQEMQAPLFQIDSRDGTISTISRINGYNDYE 1483
            ..|.||:||..:|..|.| :|: |..:.||:  |:.|.    |.||...|.|.....::|.::  
Mouse  2479 SPTPPGSFVFAVTVTDAD-IGS-NSELHYSLSGRNSEK----FHIDPLRGAIMAAGPLSGASE-- 2535

  Fly  1484 HLNVSVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEP---PAN------VTVFQH---- 1535
             :..||...|.||...:.:..|.|....:|  |.||...|.:.   |.|      ||....    
Mouse  2536 -VTFSVHVKDGGSFPKTDSTTVTVRFANKA--DFPKVRAKEQTFMFPENQPVGTLVTTITGSSLR 2597

  Fly  1536 ----AYYEVKLTENNEAPIEVM--RLNLSAGLNPEN-YRWSLWLE--EG---------------L 1576
                :||.......:...|:.:  ::::|..|:.|. .::.:|:|  :|               |
Mouse  2598 GETLSYYIASGNLGDTFQIDPLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVL 2662

  Fly  1577 DETDAHPPFEYD-----------AKNML------------------------------------L 1594
            |..|..|.||.|           .:.:|                                    :
Mouse  2663 DINDNAPTFEEDPFVSEILENLSPRKILTVSATDKDSGPNGQLDYEIVNGNQESSFTINHATGEI 2727

  Fly  1595 YALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAPK 1659
            .:::|.|||.||.|:|.:::......:::                  ...::::.|.|||||||:
Mouse  2728 RSIRPLDREKISHYELTVKSSDKGSPSQS------------------TSVKVIISILDENDNAPR 2774

  Fly  1660 FRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPARLFGIDELSGNIRLLGEL 1724
            |   .|...|.:.:::..||.||||..:|.|.|:||..||.:: :.:..|.|:..:|:|.:...|
Mouse  2775 F---SQIFSAYVSENSPLGYTVTRVTTSDEDIGINAISRYSIV-DTSLPFTINPNTGDIVISRPL 2835

  Fly  1725 SRTEHIYGFDVKATD----RMGADDGR---SGIVNVFVYIINE 1760
            :|.:         ||    |:.|.|..   |..|.:||..||:
Mouse  2836 NRED---------TDRYRIRVSAHDSGWTVSTDVTIFVTDIND 2869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 30/119 (25%)
Cadherin_repeat 325..407 CDD:206637 20/82 (24%)
Cadherin_repeat 416..524 CDD:206637 29/107 (27%)
Cadherin_repeat 534..626 CDD:206637 33/96 (34%)
Cadherin_repeat 641..>714 CDD:206637 18/88 (20%)
CA 851..925 CDD:214520 23/73 (32%)
CA 1026..1085 CDD:214520 25/94 (27%)
Cadherin_repeat 1177..1280 CDD:206637 30/113 (27%)
Cadherin_repeat 1289..1385 CDD:206637 38/200 (19%)
Cadherin_repeat 1414..1510 CDD:206637 28/97 (29%)
CA 1576..1658 CDD:214520 22/128 (17%)
Cadherin_repeat 1666..1760 CDD:206637 30/100 (30%)
Fat4NP_899044.3 EGF_CA 4430..4464 CDD:238011
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4535..4585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4677..4713
Necessary and sufficient for interaction with MPDZ. /evidence=ECO:0000269|PubMed:19506035 4708..4797
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4753..4773
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4796..4911
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4957..4981
Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 904..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637 22/102 (22%)
Cadherin_repeat 1105..1206 CDD:206637 30/119 (25%)
Cadherin_repeat 1215..1311 CDD:206637 23/107 (21%)
Cadherin_repeat 1321..1416 CDD:206637 29/106 (27%)
Cadherin_repeat 1428..1525 CDD:206637 35/116 (30%)
Cadherin_repeat 1540..1622 CDD:206637 18/84 (21%)
Cadherin_repeat 1634..1736 CDD:206637 18/108 (17%)
Cadherin_repeat 1747..1837 CDD:206637 26/105 (25%)
Cadherin_repeat 1845..1940 CDD:206637 26/99 (26%)
Cadherin_repeat 1948..2047 CDD:206637 24/98 (24%)
Cadherin_repeat 2057..2150 CDD:206637 19/96 (20%)
Cadherin_repeat 2159..2254 CDD:206637 27/107 (25%)
Cadherin_repeat 2263..2360 CDD:206637 8/96 (8%)
Cadherin_repeat 2369..2464 CDD:206637 30/95 (32%)
Cadherin_repeat 2472..2559 CDD:206637 27/116 (23%)
Cadherin_repeat 2573..2667 CDD:206637 15/93 (16%)
Cadherin_repeat 2675..2771 CDD:206637 13/113 (12%)
Cadherin_repeat 2778..2870 CDD:206637 31/102 (30%)
Cadherin_repeat 2878..2981 CDD:206637
Cadherin_repeat 2990..3085 CDD:206637
Cadherin_repeat 3095..3192 CDD:206637
Cadherin_repeat 3200..3295 CDD:206637
Cadherin_repeat 3305..3402 CDD:206637
Cadherin_repeat 3410..3508 CDD:206637
Cadherin_repeat 3516..3612 CDD:206637
EGF_CA 3804..3862 CDD:238011
EGF_CA 3864..3900 CDD:238011
EGF_CA 3902..3938 CDD:238011
EGF_CA 3941..3976 CDD:238011
LamG 3979..4142 CDD:238058
EGF_CA 4168..4200 CDD:238011
Laminin_G_2 4252..4375 CDD:460494
Blue background indicates that the domain is not in the aligned region.

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