DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and Pcdhga5

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_001032214.1	Gene:	Pcdhga5 / 291637	RGDID:	1311949	Length:	932	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	208/968 - (21%)
Similarity:	318/968 - (32%)	Gaps:	400/968 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   779 IHFHVEENV-VGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKR 842
            |.:.|.|.: .|..:|.         ::.:||.   .|.|...|.:.:.||.||:..|.:
  Rat    31 IRYSVREELDKGSFVGN---------ISKDLGL---EPRELAERGVRIISRGRSQLFSLN----- 78

  Fly   843 RLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSG 907
              ||                            .|:|:|...:|||:..:.....::.::..:.:.
  Rat    79 --PR----------------------------GGSLVTAGRIDREELCAQSAPCLISFNILVENK 113

  Fly   908 AGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQG- 971
            ..||:|.::|.|:|||.|:|........:|||...||.|.:..|   :|.|.|.|:     |||
  Rat   114 MKIYEVEVEVLDINDNFPRFRDEELKVKVNENAAAGTRLVLPFA---RDGDVGVNS-----LQGY 170

  Fly   972 --DYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSG 1034
              ..:..||::..:|:..:                           |:.||
  Rat   171 QLSANPHFSLDVKSGSDGQ---------------------------KHPEL-------------- 194

  Fly  1035 PYFRISYTGKRGLDREKQQLYNLKIIAADTGG--LSGYAHLTVLVADVNDNAPMFERISVFKDSR 1097
                   ..::.|||||:...:|.:.|.|.|.  .|...|::|.|.|.|||||:|.:
  Rat   195 -------VLEQPLDREKESALDLVLTALDGGNPVHSSTVHISVTVLDANDNAPLFTQ-------- 244

  Fly  1098 LEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKS 1162
               .||                                     |.||.
  Rat   245 ---SEY-------------------------------------RVNVP----------------- 252

  Fly  1163 RRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPMLRVHG 1227
                              |:|||||::|.|:|:|.|.|.||.|.:..:.|:
  Rat   253 ------------------ENTPVGTRLLILTATDADEGINAKLTFSFRNEE-------------- 285

  Fly  1228 VKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFD 1292
                  ||:|                                            .||:
  Rat   286 ------DKIS--------------------------------------------ETFQ------- 293

  Fly  1293 TPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQV 1357
                  .||.||:::.|.                                 .||.|....|..:|
  Rat   294 ------LDSNLGEISTIQ---------------------------------SLDYEESSFYLMEV 319

  Fly  1358 IATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRS 1422
            :|.|...::    :|..|.|.|.|:|||.||.|       ......||::..|
  Rat   320 VAQDGGALL----ASAKVLVTVQDVNDNAPEVI-------LTSLTSSVSEDCL------------ 361

  Fly  1423 TQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHL-- 1485
              |||.:...:..|.|:  ..||.|..||   ....| |:::            ...|:|.||
  Rat   362 --PGTIIALFSVHDADS--GENGEVSCSI---PKNLP-FKLE------------KSVNNYYHLLT 406

  Fly  1486 ------------NVSVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYY 1538
                        |::|...|.|:|.||...  .::|:...:.|.|.:..:|.            |
  Rat   407 TSALDREETSDYNITVTVVDRGTPPLSTEN--HISLKVADINDNPPTFSRPS------------Y 457

  Fly  1539 EVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEE-GLDETDAHPPFEYDAKNMLLYALKPFDR 1602
            ...::|||...:.:..:|.....:.:|.|.:..|.| ...|.........::...:||||:.||.
  Rat   458 STSISENNPRGVSIFSVNAYDADSGDNARITYSLAEYTFQEVPVSSYVSINSDTGVLYALQSFDY 522

  Fly  1603 EHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAPK-----FRG 1662
            ||:...||.:.|.                 |.....||.| ..:.:.:.|:|||.|:     ...
  Rat   523 EHLRDLQLLVTAK-----------------DSGNPPLSSN-ASLSLFVLDQNDNTPEILYPAIPT 569

  Fly  1663 NGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLL--NEPARLFGIDELSGNI 1718
            :|...|.:.|:||..||.||:|.|.|.|.|.||.:.||||  :||. ||.|...:|.:
  Rat   570 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPG-LFSIGLHTGEV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520	14/73 (19%)
		CA	1026..1085	CDD:214520	17/60 (28%)
		Cadherin_repeat	1177..1280	CDD:206637	19/102 (19%)
		Cadherin_repeat	1289..1385	CDD:206637	18/95 (19%)
		Cadherin_repeat	1414..1510	CDD:206637	23/109 (21%)
		CA	1576..1658	CDD:214520	20/81 (25%)
		Cadherin_repeat	1666..1760	CDD:206637	25/55 (45%)
Pcdhga5	NP_001032214.1	Cadherin_2	30..112	CDD:285466	23/127 (18%)
		Cadherin_repeat	137..238	CDD:206637	35/156 (22%)
		Cadherin_repeat	246..343	CDD:206637	44/282 (16%)
		Cadherin_repeat	355..448	CDD:206637	27/126 (21%)
		Cadherin_repeat	456..558	CDD:206637	27/131 (21%)
		Cadherin_repeat	579..666	CDD:206637	24/49 (49%)
		Cadherin_C_2	688..772	CDD:293101
		Cadherin_tail	809..>905	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910