Protein Alignment Cad89D and PCDH11X

DIOPT Version :10

• Sequence 1: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Sequence 2: XP_011529212.1
• Gene: PCDH11X / 27328
• HGNCID: 8656
• Length: 1376
• Species: Homo sapiens
• Alignment Length: 1251
• Identity: 255/1251 - (20%)
• Similarity: 395/1251 - (31%)
• Gaps: 539/1251 - (43%)

  Fly   394 LARIEVEVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFLYNLVETKDAAG 458
            |.:|...:.|:|||.|.|.|...||||.||...........|||.|.|.|....|.|:::::..|
Human   151 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFG 215

  Fly   459 AFRIDSRTGWITVRDDRL--------LDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVE 515
            ...|::..|      |::        ||||::.:..:.|:.       .|....::...:.:||.
Human   216 LDVIETPEG------DKMPQLIVQKELDREEKDTYVMKVKV-------EDGGFPQRSSTAILQVS 267

  Fly   516 ITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFR 580
            :|  |||||.|.|:...: |..:|.|||.|..:.|:.|.|.|.|.|
Human   268 VT--DTNDNHPVFKETEI-EVSIPENAPVGTSVTQLHATDADIGEN------------------- 310

  Fly   581 LDNKNGTIYVGGPLRRGRIAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFW 645
                                                                             
Human   311 ----------------------------------------------------------------- 310

  Fly   646 VGANTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQF 710
                                                                             
Human   311 ----------------------------------------------------------------- 310

  Fly   711 EAVANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRPVIEEIN 775
             |..::.|:|                            |::|:...:
Human   311 -AKIHFSFSN----------------------------LVSNIARRL------------------ 328

  Fly   776 MNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKS 840
                 ||:  |...|:|                 |.:|
Human   329 -----FHL--NATTGLI-----------------TIKE--------------------------- 342

  Fly   841 KRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLV 905
                                                      .||||:.|:::|.|:.. ..||:
Human   343 ------------------------------------------PLDREETPNHKLLVLAS-DGGLM 364

  Fly   906 SGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAI-LIQDADEGPNAEFRVQL 969
            ....:..||  |.|||||.|..:....|..:|:..|:...:.:|..| ||...|:..:...||..
Human   365 PARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC 427

  Fly   970 QGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSG 1034
                                .|.|::|        |.|...::::              |.|.:.
Human   428 --------------------FTDHEIP--------FRLRPVFSNQ--------------FLLETA 450

  Fly  1035 PYFRISYTGKRGLDREKQQLYNLKIIAADTG--GLSGYAHLTVLVADVNDNAPMFERISVFKDSR 1097
            .|          ||.|..:.|.:|::|||.|  .|:..|.|.:.|.|.|||||:|.:..|
Human   451 AY----------LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV----- 500

  Fly  1098 LEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKS 1162
                                                                             
Human   501 ----------------------------------------------------------------- 500

  Fly  1163 RRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPMLRVHG 1227
                    |...|     |:...|.::.::||.|.|.|.||.::|.|       .|..|
Human   501 --------TVSIP-----ENNSPGIQLTKVSAMDADSGPNAKINYLL-------GPDAP------ 539

  Fly  1228 VKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDG----LKDSTCLRFTVMDVNNHAPTFKKSW 1288
             ..|::|..:|.|:|...|....|.....|:...|.    |..:..:..:::|.|:::|.|..:.
Human   540 -PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 603

  Fly  1289 YSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKY 1353
            |:|..||...:...:|.:|..|.|:|:|:.:|.::.|.:..|||...:||::.....|||.::.|
Human   604 YNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESY 668

  Fly  1354 SFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAY 1418
            :|.|.|.|...|.:  |||..|.:||:|:|||:|.||          ..||.....|:||
Human   669 TFYVKAEDGGRVSR--SSSAKVTINVVDVNDNKPVFI----------VPPSNCSYELVLP----- 716

  Fly  1419 LDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYE 1483
               ||.|||.|.|:.|:|.|.  ..|..|.|||.....: .||.||...|.|:.:.:.: ..|..
Human   717 ---STNPGTVVFQVIAVDNDT--GMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCD-VTDLG 774

  Fly  1484 HLNVSVIASDVGSPALSATAIVIVNL-QGQAVTDPP-------KSTPKPEPP----ANVTVFQHA 1536
            ...|.|.|:|:|.|. |..::||||| ..::||:..       |||..|..|    |:|:.....
Human   775 LHRVLVKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 838

  Fly  1537 YYEV------------------KLTENNEAP-IEVMRLNLS----AGLNPENYRWSLWLEEGLDE 1578
            |.::                  .:....:|| ::..:.|..    |..||||.:..:..::  .:
Human   839 YVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMKKK--KK 901

  Fly  1579 TDAHPPFEYDAKNMLL 1594
            ...|.|     ||:||
Human   902 KKKHSP-----KNLLL 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637	4/12 (33%)
		Cadherin_repeat	416..524	CDD:206637	30/115 (26%)
		Cadherin_repeat	534..626	CDD:206637	12/91 (13%)
		Cadherin_repeat	641..>714	CDD:206637	1/72 (1%)
		CA	851..925	CDD:214520	17/73 (23%)
		CA	1026..1085	CDD:214520	20/60 (33%)
		Cadherin_repeat	1177..1280	CDD:206637	25/106 (24%)
		Cadherin_repeat	1289..1385	CDD:206637	34/95 (36%)
		Cadherin_repeat	1414..1510	CDD:206637	34/96 (35%)
		CA	1576..1658	CDD:214520	6/19 (32%)
		Cadherin_repeat	1666..1760	CDD:206637
PCDH11X	XP_011529212.1	Cadherin_2	57..131	CDD:462413
		Cadherin_repeat	172..274	CDD:206637	30/116 (26%)
		Cadherin_repeat	282..380	CDD:206637	39/390 (10%)
		CA	413..493	CDD:214520	28/131 (21%)
		Cadherin_repeat	501..595	CDD:206637	27/112 (24%)
		Cadherin_repeat	603..698	CDD:206637	34/96 (35%)
		Cadherin_repeat	710..801	CDD:206637	37/103 (36%)
		Protocadherin	804..1005	CDD:462451	24/116 (21%)
		FAM47	<1215..1283	CDD:405345