DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and PCDHB5

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_056484.2	Gene:	PCDHB5 / 26167	HGNCID:	8690	Length:	795	Species:	Homo sapiens

Alignment Length:	920	Identity:	200/920 - (21%)
Similarity:	320/920 - (34%)	Gaps:	302/920 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   663 LIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELS-------------EFK--RKVYQFE- 711
            |::|.|.|.:     .||  :|...|....:..:.::|.             .:|  :::.|.:
Human    22 LLWEAGSEAV-----RYS--IPEETESGYSVANLAKDLGLGVGELATRGARMHYKGNKELLQLDI 79

  Fly   712 AVANYLFANSSQSLVMSRSSSPL-----TTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRPVI 771
            ...|.|........||..::.|.     ..:.:|.:.....:.:|::..|....||:::.|:
Human    80 KTGNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLK--- 141

  Fly   772 EEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSR 836
                       :.|:...|.:..|......::.:|.:..|          .|:..|.|.....:|
Human   142 -----------IPESTQPGTVFPLKIAQDFDIGSNTVQNY----------TISPNSHFHVATHNR 185

  Fly   837 SSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYS 901
            .  ..|:.|..::..|                               ||||::|...||:
Human   186 G--DGRKYPELVLDKA-------------------------------LDREERPELSLTL----- 212

  Fly   902 TGLVSGA----GIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILI---QDADE 959
            |.|..||    |...:.|.|.|.|||||:|....|...:.||.      .:|..:::   :|.|.
Human   213 TALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENS------PLNSLVVVVSARDLDA 271

  Fly   960 GPNAEFRVQL-QGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTT 1023
            |........| |||                        ..|..|.|        || |..|:..
Human   272 GAYGSVAYALFQGD------------------------EVTQPFVI--------DE-KTAEIRL- 302

  Fly  1024 FMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNAPMFE 1088
                                ||.||.|....||::|:|.|.|||||...:.:.|.|||||
Human   303 --------------------KRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDN----- 342

  Fly  1089 RISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAG 1153
                                           ||:.|.:.:.:|.|.:.|
Human   343 -------------------------------APELTMSTLSSPTPENAP---------------- 360

  Fly  1154 LGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTP 1218
                                            .|.|...|.||.|.|.|..:...:|.:
Human   361 --------------------------------ETVVAVFSVSDPDSGDNGRMICSIQND------ 387

  Fly  1219 GMPMLRVHGVKYF-------AIDKLSGELSVNYPLSANIEIMLNLTVTDI--DGLKDSTCLRFTV 1274
             :|.|....:|.|       .:|:           .:..|..:.:||||:  ..||....:...|
Human   388 -LPFLLKPTLKNFYTLVTQRTLDR-----------ESQAEYNITITVTDMGTPRLKTEHNITVLV 440

  Fly  1275 MDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTL---SDSHLPF----TI 1332
            .|||::||.|.::.|:....|.......:|.::|.|.|.|.||.:||:|   .:.||..    :|
Human   441 SDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSI 505

  Fly  1333 KPASGVLKIGGQLDRELKDKYSFQVIATD-NAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQT 1396
            ...:|.|.....||.|....:.|:|.||| .:|.   :||...|.|.|||.|||.| |:.|..|.
Human   506 NADNGHLFALRSLDYEALQAFEFRVGATDRGSPA---LSSEALVRVLVLDANDNSP-FVLYPLQN 566

  Fly  1397 KAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLF 1461
            .:       |..|.::|       |:.:||..|.::.|:|.|:  ..|..:.|.:. :..:..||
Human   567 GS-------APCTELVP-------RAAEPGYLVTKVVAVDGDS--GQNAWLSYQLL-KATEPGLF 614

  Fly  1462 QIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATA---IVIVNLQGQAVTDPPKSTPK 1523
            .:.:.:|.:.| :|:....|.....:.|:..|.|.|..||||   :::|:...|.....|::.|.
Human   615 SMWAHNGEVRT-ARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPA 678

  Fly  1524 PEPPANVTVF 1533
            .....::||:
Human   679 QAQADSLTVY 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637	11/66 (17%)
		CA	851..925	CDD:214520	19/77 (25%)
		CA	1026..1085	CDD:214520	21/58 (36%)
		Cadherin_repeat	1177..1280	CDD:206637	25/111 (23%)
		Cadherin_repeat	1289..1385	CDD:206637	34/103 (33%)
		Cadherin_repeat	1414..1510	CDD:206637	24/98 (24%)
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
PCDHB5	NP_056484.2	Cadherin_2	30..112	CDD:311943	12/88 (14%)
		Cadherin_repeat	140..238	CDD:206637	29/159 (18%)
		Cadherin_repeat	247..342	CDD:206637	37/154 (24%)
		Cadherin_repeat	356..446	CDD:206637	27/155 (17%)
		Cadherin_repeat	454..556	CDD:206637	34/104 (33%)
		Cadherin_repeat	575..663	CDD:206637	24/98 (24%)
		Cadherin_C_2	684..767	CDD:318652	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000