DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and Fat2

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_001025159.1 Gene:Fat2 / 245827 MGIID:2685369 Length:4351 Species:Mus musculus


Alignment Length:2764 Identity:555/2764 - (20%)
Similarity:943/2764 - (34%) Gaps:943/2764 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 IRLREDAQVGKEILRLQAYPRSTAA-LKGADASGDHK-YFNLTEHNATTLVVSLARSLERL---- 134
            :.||:||.|||.|:.:.|....... ||....||:.: ||:|...:.   |:||.||...|    
Mouse   571 VSLRQDAPVGKSIMAVSAIDMDELQNLKYEIVSGNEQDYFHLNHFSG---VISLKRSFMNLTAVR 632

  Fly   135 -------------------------VDRDVPR--------------NLLKFRILCAGKQ-EKLEE 159
                                     |.:| ||              ::.|..:..||.| :::.|
Mouse   633 PTVYSLKITASDGKNYASPTTLKVTVVKD-PRSEVPVQCDKTGVLTHITKTILQSAGLQGQEMGE 696

  Fly   160 GSYLSITVYIEDVNDNAPEFL-NVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNSEVHFSMST 223
            ..:.|:..|  .:|.:||:|. :.|..:|:.|...:                |||.:.:   .:|
Mouse   697 EDFTSLGNY--QINHHAPQFEDHFPQSIDILEQVPV----------------NTPLAHL---AAT 740

  Fly   224 VPE--------QLSADGSP--YFALKSPHRPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQAN 278
            .|:        .:.|||:.  .|.::. ...||.:...||::. ...:.|.:..:|.|||...:.
Mouse   741 DPDPGFHGRLVYVIADGNEEGCFDIEL-ETGLLTVAAALDYET-TSFYVLNVTVYDLGTPPKSSW 803

  Fly   279 TTITINVRDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQDSL-NASLVYDII 342
            ..:|:.|:|.:|.||:|..|.|:..|:|   .|.|...:     ..:...|.||. |..:.|.::
Mouse   804 KLLTVTVKDWNDKPPRFPPGGYQLTISE---DTEVGTTV-----AELKTRDTDSEDNGRVRYTLL 860

  Fly   343 SGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKK----ALARIEVEVLD 403
            :..|:  |.::|..|.:.:..::|.|.|.    .::|:.|||  |.|.|.    ::..:.|.:.|
Mouse   861 TPTEK--FSLHPLTGELVVTGQLDRESEP----QYILKAEAR--DQPTKGHQLFSVTDVIVTLED 917

  Fly   404 LNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRTGW 468
            :|||.|:...::.::.:.|::|.|..:..::|.|.|.|...|..|.||:  |..|.||:|..||.
Mouse   918 INDNPPQCITEHSSLKVPEDMPLGTVLTFLDASDPDLGPAGEVKYILVD--DVHGTFRVDPMTGA 980

  Fly   469 ITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKV--QVEITLLDTNDN--TPKFE 529
            :::  ::.||.|:|....|:..|.:..          :|...:.  .||:.::|.|:|  :|.|.
Mouse   981 LSL--EKELDFERRAGYNLSFWASDSG----------RPLARRTLCHVEVLVMDVNENLHSPHFS 1033

  Fly   530 HGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNGTIYVGGPL 594
             ..:|:.:|..|:|.|..:..|.|.|.|.|.:|.|.|.|:  .|:|...|.::...|.:....||
Mouse  1034 -SFVYQGQVQENSPAGTQVMVVTAQDDDSGLDGELQYFLR--AGTGLEAFSINQDTGMLETLAPL 1095

  Fly   595 RRGRIAVF---VEATDQPTNPSERRFSLAVITIEVYATIDD--QAIDFVGAPYEFW--VGANTPL 652
            .|.....:   |.|.|:.:.|      |:.:| |||..:.|  ..|..:..|. |:  |..:.||
Mouse  1096 DREFTPYYWLTVLAVDRGSVP------LSAVT-EVYIEVTDINDNIPSMSRPV-FYPSVKEDAPL 1152

  Fly   653 GTSV-----------GQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRK 706
            ||||           .|.:.|.....|:.:.:.::|      ||     :|:::..::|....:.
Mouse  1153 GTSVLQLEAWDPDFSSQGKLTFNLTSGNHMGHFIVH------PF-----TGLLSTAKQLDRENKD 1206

  Fly   707 VYQFEAVA------------------------NYLFANSSQSLVMSRSSSPLT------------ 735
            .|..|...                        :.:|::...::.:|...|||:            
Mouse  1207 EYVLEVTVQDNGDPPLRSTSRVVVCVLDVNDNSPMFSHKLFNVRLSERLSPLSPEPVYRLVASDP 1271

  Fly   736 ------TIASPAELSDE---------GV--------------------------LITNLTIHIVN 759
                  :|....|.|||         ||                          |.|::.:||..
Mouse  1272 DEGLNGSITYSIEESDEESFRIDPVTGVVSSSSTFAAGEYNILTIKATDSGQPALSTSVRLHIEW 1336

  Fly   760 KPEQK---VPLR--------PVIEEINMN-------------VIHFHVE----------ENVVGG 790
            .|:.:   :||.        .|:|...:|             :..||:.          |...|.
Mouse  1337 IPQPRPSSIPLSFDESHYSFAVMETDPVNHMLGVISVEGRPGLFWFHISDGDKDMDFDIEKTTGS 1401

  Fly   791 IIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMG--------------SRFRSRNRSRSSKSK 841
            |:           :...|.|.|:     :|.|:|:.              ....:.|..|....:
Mouse  1402 IV-----------IARPLDTRRK-----SSYNLTVEVTDGFHTIATQVHILMIANINHHRPQFLQ 1450

  Fly   842 RRLPRRLVGDA--NIKLRYIIANQQE----VVNKISITED-------------GTLLTLTGLDRE 887
            .....|:..|.  .::|..:.|..|:    ::..|..:.|             |.|:|:..||..
Mouse  1451 DHYDIRVPQDTLPGVELLRVQATDQDHGKGLIYTIHSSRDPGSANLFQLDPSSGVLVTVGTLDLH 1515

  Fly   888 QQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAI 952
            ..||..:..::.....:........|.|.|:|.|.::|.|....|...:.:....||||....|:
Mouse  1516 SGPSQHILTVMVRDQEMPIKRNFVWVTIHVEDGNLHSPHFTQPRYEANVPDTTTPGTELLQVRAV 1580

  Fly   953 LIQDADEGPNAEFRVQ-LQGDYSDEFSIEYVNG--TSSENSTH---------------------- 992
               |||.|.|||.... |:|:....|:|:.:.|  |.::...|                      
Mouse  1581 ---DADRGANAEVHYSFLKGNSEGFFNIDSLLGIITVAQRLDHVHLNRHALTVKAEDQGSPQRHD 1642

  Fly   993 ------HKMPSTTGAFNIFNLTDQWNDEFKYQ------------------------ELHTTFMQT 1027
                  |..||.:.| .||:     .||:..:                        ||......:
Mouse  1643 LAMVVVHVHPSDSSA-PIFS-----KDEYFIEIPESVPIGSPILLISAASSSDVTYELREGNKNS 1701

  Fly  1028 NFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNAPMFERISV 1092
            .|.::|  |..:..|.|| ||.||...|.|||..::..|:.......|.:.|.|||||.|.: |.
Mouse  1702 VFSMNS--YSGLISTQKR-LDHEKVSSYQLKIRGSNMAGVFTEVVALVYIIDENDNAPAFLK-ST 1762

  Fly  1093 F-----------------KDSRLEIREYTTDME----------------IYFVESSSG------- 1117
            |                 .:|.|.||...:|.|                .:.::.|.|       
Mouse  1763 FVGHISEAAPLHSLILGEDNSPLVIRASDSDQEANSLLVYKILEPEALKFFKIDPSMGTLTITSE 1827

  Fly  1118 ----------------------MTAPQATAAMML------APP-------------PYHIPGSPR 1141
                                  :.||::...::.      :||             |.| ||...
Mouse  1828 LDYETTPLFQFSIYVHDQGTPILFAPRSARVIIHVRDVNDSPPRFSEQIYEVAVVEPIH-PGMEL 1891

  Fly  1142 FNVDRE---------------------RSVGAGLGVVARAKSR---RRMVRALTTKCPLFAIYED 1182
            ..|..|                     ..:...:.||..|..|   :..:||..      .:|:|
Mouse  1892 LTVQAEDNDSKVTYSIKTSNTDEAVTIHPITGQISVVNPAALRLFPKLNIRAFD------GLYQD 1950

  Fly  1183 TPVGTKVLQLSASDEDFGKNALLHYELQGEQ-------VERTPG---MPMLRVHG------VKYF 1231
            |.| .|:....|.|:          .||.:|       .|.||.   :.:|.|||      :.||
Mouse  1951 TAV-VKISLTQALDK----------SLQFDQDIYRARVTENTPHSNVLVILGVHGNHLNDTLSYF 2004

  Fly  1232 AIDKLSGELSVNYPLSANI----------------EIMLNLTVTDIDGLKDSTCLRFTVMDVNNH 1280
            .   |:|....:...||.:                |:.:.:....:........:|.:|.|||::
Mouse  2005 L---LNGTDLFHMVKSAGVLQTRGVTFDREQQDTHEVAVEVRDNRVPRRVAQALVRVSVEDVNDN 2066

  Fly  1281 APTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKP----------- 1334
            .|.|:...|.....:|.....||.|::|.|.|.|.|..:||..::.:..|.|.|           
Mouse  2067 IPEFQHLPYYTVIQDGTEPGDVLFQVSATDKDLGANGTVTYGFAEDYAYFRIDPYVGDISLKKPF 2131

  Fly  1335 ----------------------------------------------------------------- 1334
                                                                             
Mouse  2132 DYQALNKYHLRVTARDAGTPPLQTEVEVHVTVRNKSNPLFQSPYYKVKVPENITLYTPILHTQAR 2196

  Fly  1335 ------------------------ASGVLKIGGQLDRELKDKYSFQVIATDNAPVMQRMSSSVDV 1375
                                    .:|||.:.|.||.|.|:|:.|.|.|||.|   ....|...|
Mouse  2197 SPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTA---LGSFSEATV 2258

  Fly  1376 EVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNV 1440
            ||.|.|||||.|.|...                     ||...:...:...|.|.||.|.|:|:.
Mouse  2259 EVLVEDINDNPPTFSQL---------------------VYSTSVSEGSPAQTPVIQLLASDQDSG 2302

  Fly  1441 GNGNGLVLYSIRHQEMQ-APLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAI 1504
            .|.:  |.|.|...... :..|:|:...|.:.||..:: |..::|..|.|.|:|.|.|.|:...:
Mouse  2303 QNQD--VSYQIVEDGSDVSKFFRINGSTGEMFTIQELD-YEAHQHFRVKVRATDRGDPPLTGETL 2364

  Fly  1505 VIVNLQGQAVTDPPKSTPKPEPPANVTVFQ---HAYYEVKLTE---------------------- 1544
            |:||:..  :.|.|....:|:..|||:...   |...:|:..:                      
Mouse  2365 VVVNVSD--INDNPPEFREPQYEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHF 2427

  Fly  1545 --NNEAPIEVMRLNLSAGLNPENYRWSLWLEEG---------LDETDAH---PPFEYDAKNMLLY 1595
              |:.:.| :...||.......:|...:...:|         ::.|:|:   |.|:.:     :|
Mouse  2428 SINSTSGI-ISMFNLCKKQLDSSYNLRVGASDGVFQATVPVYINTTNANKYSPEFQQN-----VY 2486

  Fly  1596 ALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVD--------------------------- 1633
            ..:..:...:....:.:.|  :.:::..|..|.|.:::                           
Mouse  2487 EAELAENAKVGTKVIELLA--IDKDSGPYGTVDYTIINKLAGERFFINPSGQITTLQKLDRENST 2549

  Fly  1634 ERIEGLSLNE---------CRILVHIADENDNAPKFRGNGQPIVAVLPQSASFGYPVTRVEANDL 1689
            ||:..:.:..         |.:.:.:.|||||||:|:.:|..:  .:|.:.|...|:.:|.|.|.
Mouse  2550 ERVIAIKIMARDGGGKVAFCTVKIILTDENDNAPQFKASGYTV--SIPSNVSRDSPIIQVLAYDA 2612

  Fly  1690 DEGLNAEIRYRL-----LNEPARLFGIDELSGNIRLLGELSRTEHIYGFDVKATD-RMGADDGR- 1747
            |||.||::.|.:     |.|  .:..::..:|.:::      .|.:.|.:.||.| .:.|.||. 
Mouse  2613 DEGRNADVTYSVDSTEDLAE--EIIEVNPTTGVVKV------KESLVGLENKAVDFNIKAQDGGP 2669

  Fly  1748 ---SGIVNVFVYIINEAKQVRLVVAGMPVEVERRIEGLMEALSDAIGKDVRVRLLEP--YS--GG 1805
               ..:|.|.:.::  ..::.|.....|:......|.|.|  ...||....|...:|  ||  .|
Mouse  2670 PHWDSLVPVRLQVV--PNEIPLPKFSEPLYTFSASEDLPE--GSEIGSVKAVAAQDPIIYSLVQG 2730

  Fly  1806 LEPATNA-YIYAVDPHTNSIMEMEQLQD--ALAGLQLD----------------ALQLQQQKLDG 1851
            ..|.:|: .::::|..| .::::::..|  :....|:|                ::.:|.:.::.
Mouse  2731 TTPESNSDDVFSLDQDT-GVLKVKKAMDHESTKWYQIDLMAHCPHEDTDLVSLVSVNIQVEDVND 2794

  Fly  1852 GKPMPRILELAEFGQLARPAHASASSFM-GGLEFVTVVLLALISLGALIAACCYVCMRQKRRLWS 1915
            .:|   :.|       |.|..|..:..| ||...:.|..                         :
Mouse  2795 NRP---VFE-------ADPYKAFLTENMPGGTTVIQVTA-------------------------N 2824

  Fly  1916 QRDFSASDAGLTYTIA-----------GIGSPRGQKQRRQRQQRHTQRCSK--------GSTGSQ 1961
            .:| :.||..::|.::           .:.|..|.....|.....||:..:        |.| .|
Mouse  2825 DQD-TGSDGQVSYRLSVEPGSNIHQLFAVDSESGWITTLQELDCETQQTYRFYVVAFDHGQT-IQ 2887

  Fly  1962 RPTSAFMPESVCSSAQTQSTATATEKLEQQLHHHHQQQAMATQQQHHQYLNEQQRQ--------- 2017
            ..:.|.:..|:...........:.:.....:.::...:.:||.:.....::||.||         
Mouse  2888 LSSQALVEVSITDENDNPPRFASEDYRGSVVENNEPGELVATLKTLDADISEQNRQVTCYITEGD 2952

  Fly  2018 ---------------------QKREYI----------DVPLPKSIAKAAAVTSGGD--------- 2042
                                 ..||:|          |.....|:.....|....|         
Mouse  2953 PLGQFSISQVGDEWRITSRKTLDREHIAKYLLRITASDGKFQASVPVEVFVLDINDNSPQCSQLL 3017

  Fly  2043 --GAVGVGSTP--FVLKYNACQPVNNLNNYETSLFSLHS-----------TGQDSGVEFL--SSR 2090
              |.|....||  |:||.:|.....:.|...|  :|||.           ||:.:.:..|  ..:
Mouse  3018 YTGKVREDVTPGHFILKVSAIDVDMDTNAQIT--YSLHGPGAQEFKLDPHTGELTTLSVLDRERK 3080

  Fly  2091 ELYETSPDSFQHGGSKRGNNTEVLCPRHAKAHLE 2124
            ::|.....:...||..        |......|:|
Mouse  3081 DVYNLVAKATDGGGQS--------CQAEVTLHIE 3106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 24/116 (21%)
Cadherin_repeat 325..407 CDD:206637 22/86 (26%)
Cadherin_repeat 416..524 CDD:206637 29/109 (27%)
Cadherin_repeat 534..626 CDD:206637 27/94 (29%)
Cadherin_repeat 641..>714 CDD:206637 19/85 (22%)
CA 851..925 CDD:214520 18/92 (20%)
CA 1026..1085 CDD:214520 20/58 (34%)
Cadherin_repeat 1177..1280 CDD:206637 29/134 (22%)
Cadherin_repeat 1289..1385 CDD:206637 38/195 (19%)
Cadherin_repeat 1414..1510 CDD:206637 30/96 (31%)
CA 1576..1658 CDD:214520 17/120 (14%)
Cadherin_repeat 1666..1760 CDD:206637 25/103 (24%)
Fat2NP_001025159.1 Cadherin_repeat 38..143 CDD:206637
Cadherin_repeat 152..249 CDD:206637
Cadherin_repeat 366..454 CDD:206637
Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..661 CDD:206637 23/92 (25%)
Cadherin_repeat 719..815 CDD:206637 24/116 (21%)
Cadherin_repeat 825..921 CDD:206637 27/111 (24%)
Cadherin_repeat 931..1026 CDD:206637 29/108 (27%)
Cadherin_repeat 1036..1133 CDD:206637 31/105 (30%)
Cadherin_repeat 1141..1238 CDD:206637 18/108 (17%)
Cadherin_repeat 1247..1335 CDD:206637 14/87 (16%)
Cadherin_repeat 1353..1444 CDD:206637 15/106 (14%)
Cadherin_repeat 1452..1551 CDD:206637 19/98 (19%)
Cadherin_repeat 1560..1650 CDD:206637 20/92 (22%)
Cadherin_repeat 1664..1754 CDD:206637 21/92 (23%)
Cadherin_repeat 1762..1867 CDD:206637 11/104 (11%)
Cadherin 1883..1959 CDD:356102 17/83 (20%)
Cadherin_repeat 1972..2066 CDD:206637 19/96 (20%)
Cadherin_repeat 2074..2163 CDD:206637 15/88 (17%)
Cadherin_repeat 2176..2268 CDD:206637 23/94 (24%)
Cadherin_repeat 2276..2375 CDD:206637 30/103 (29%)
Cadherin_repeat 2383..2475 CDD:206637 12/92 (13%)
Cadherin_repeat 2485..2581 CDD:206637 11/97 (11%)
Cadherin_repeat 2590..2683 CDD:206637 25/102 (25%)
Cadherin_repeat 2697..2795 CDD:206637 18/100 (18%)
Cadherin_repeat 2803..2904 CDD:206637 20/127 (16%)
Cadherin_repeat 2913..3009 CDD:206637 12/95 (13%)
Cadherin_repeat 3018..3111 CDD:206637 22/99 (22%)
Cadherin_repeat 3122..3211 CDD:206637
Cadherin_repeat 3226..3319 CDD:206637
Cadherin_repeat 3328..3424 CDD:206637
Cadherin_repeat 3433..3524 CDD:206637
Cadherin_repeat 3544..3621 CDD:206637
Laminin_G_2 3802..3920 CDD:366983
EGF_CA 3953..3986 CDD:238011
EGF 3992..4022 CDD:333761
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4313..4340
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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