DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and FAT2

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_001438.1 Gene:FAT2 / 2196 HGNCID:3596 Length:4349 Species:Homo sapiens


Alignment Length:1984 Identity:444/1984 - (22%)
Similarity:735/1984 - (37%) Gaps:583/1984 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 LKGADASGDHKYFNLTEHNATTLVVSLARSLERLVDRDVPRNLLKFRILCAGKQEKLEEGSYLSI 165
            :.|.|...|   |::.:   ||..:.:||.|:       .|....:.:..     ::.:||....
Human  1384 ISGGDKDMD---FDIEK---TTGSIVIARPLD-------TRRRSNYNLTV-----EVTDGSRTIA 1430

  Fly   166 T----VYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNSEVHFSMSTVPE 226
            |    ..|.::|.:.|:||...|.|.|.::| :..:....|||.|:||..:....:|.|..    
Human  1431 TQVHIFMIANINHHRPQFLETRYEVRVPQDT-VPGVELLRVQAIDQDKGKSLIYTIHGSQD---- 1490

  Fly   227 QLSADGSPYFALKSPHRPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQANTTITINVRDVDDL 291
                .||.......|...:|:...:||..:|..|..|.:...|:..|..:....:||:|.|.:..
Human  1491 ----PGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLH 1551

  Fly   292 PPKFTEGVYRTRINEFYPMTGVPIRIPLYFAP-----PIMAFDQD-SLNASLVYDIISGNERQLF 350
            ||:||:..|..             .:|...||     .:.|.|.| .:||.:.|.::.||....|
Human  1552 PPRFTQLHYEA-------------SVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFF 1603

  Fly   351 RVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADY 415
            .:|...|::.|.:::|....:    ...|.::|..:.:|....||.:.:.|...:.:.|.|....
Human  1604 NINALLGIITLAQKLDQANHA----PHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664

  Fly   416 YNISIVENLPTGFSVLQVNAVDRDQGENSEFLYNLVE-TKDAAGAFRIDSRTGWITVRDDRLLDR 479
            |.:.|.|::|.|..:|.|:|:     ..||..|.|.| .||  |.|.::|.:|.|:.:  :.||.
Human  1665 YFVEIPESIPVGSPILLVSAM-----SPSEVTYELREGNKD--GVFSMNSYSGLISTQ--KKLDH 1720

  Fly   480 EQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLDTNDNTPKF----------EHGNLY 534
            |:..|.||.:.......::.|           |.|.:.::|.|||.|.|          |...||
Human  1721 EKISSYQLKIRGSNMAGAFTD-----------VMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY 1774

  Fly   535 EFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNGT------------ 587
            ...:..| ...:||.   |.|.|:..|..|:|::..|:...:  |::|...||            
Human  1775 SMIMDKN-NNPFVIH---ASDSDKEANSLLVYKILEPEALKF--FKIDPSMGTLTIVSEMDYESM 1833

  Fly   588 ------IYV---GGPL----RRGRIAVFV-EATDQPTNPSERRFSLAVI--------TIEVYATI 630
                  :||   |.|:    |..::.:.| :..|.|...||:.:.:|::        .:.|.|:.
Human  1834 PSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASD 1898

  Fly   631 DDQAID---------------------------FVGAPYEFWVGANTPLGTSVGQVRTTLIYEGG 668
            :|..::                           |:|...:..:.|:..|......|:.:|.....
Human  1899 EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLTIRASDGLYQDTALVKISLTQVLD 1963

  Fly   669 DEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQSLVMSRSSSP 733
            ..:.:| ...|...|...:::|..::.:..:.:.....:       :|...|.:....|.:|:..
Human  1964 KSLQFD-QDVYWAAVKENLQDRKALVILGAQGNHLNDTL-------SYFLLNGTDMFHMVQSAGV 2020

  Fly   734 LTT--IASPAELSDEGVLITNLTIHIVNKPEQKVP---LRPVIEEINMNVIHF-HVEENVV---G 789
            |.|  :|...|..|...|...:.   .|:..|:|.   :|..||::|.|...| |:....:   |
Human  2021 LQTRGVAFDREQQDTHELAVEVR---DNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDG 2082

  Fly   790 GIIGQLLYKNGINLVNNELGT-------------------------------YREM--------- 814
            ...|.:|::  ::..:.:|||                               |:.:         
Human  2083 TEPGDVLFQ--VSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIA 2145

  Fly   815 -----PSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLV-----------GDANIKLRYIIANQ 863
                 ||..:...:.:..|.:|....:|...|.|:|..:.           ....::|.|.|..:
Human  2146 RDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEE 2210

  Fly   864 QEVVNKISITEDGT-LLTLTG-LDREQQPSYELTV-IVEYSTGLVSGAGIYQVNIKVDDVNDNAP 925
            :.::  :..|:..| :||:|| ||.|.:..:..|| ..:.:.|..|.|   .|.:.|:|||||.|
Human  2211 EPLM--LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEA---TVEVLVEDVNDNPP 2270

  Fly   926 KFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENS 990
            .|:.|.|...|:|.....|.:..   :|..|.|.|.|.:...|:..|.||......:||::.|.|
Human  2271 TFSQLVYTTSISEGLPAQTPVIQ---LLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMS 2332

  Fly   991 THHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLY 1055
            |                         .||                           ||.|.||.:
Human  2333 T-------------------------VQE---------------------------LDYEAQQHF 2345

  Fly  1056 NLKIIAADTGG--LSGYAHLTVLVADVNDNAPMFER------IS--------VFK---------- 1094
            ::|:.|.|.|.  |:|...:.|.|:|:|||.|.|.:      :|        |.|          
Human  2346 HVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRD 2410

  Fly  1095 DSRLE--IREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVV 1157
            .||||  |.....|.. :|:.||||:.:       |......|:..|  :|:    .|||..||.
Human  2411 TSRLEYLILSGNQDRH-FFINSSSGIIS-------MFNLCKKHLDSS--YNL----RVGASDGVF 2461

  Fly  1158 ARAKSRRRMVRALTTKCPLFA-----------IYEDTPVGTKVLQLSASDEDFGKNALLHY---- 1207
            .....    |...||....::           :.|:..|||||:.|.|.|:|.|....:.|    
Human  2462 RATVP----VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIIN 2522

  Fly  1208 ELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRF 1272
            :|..|:....|...:.        .:.||..|.|....::  |::|    ..|..|......::.
Human  2523 KLASEKFSINPNGQIA--------TLQKLDRENSTERVIA--IKVM----ARDGGGRVAFCTVKI 2573

  Fly  1273 TVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLS------------- 1324
            .:.|.|::.|.||.|.|:........|||.:.|:.|.|.|.|:||::||:::             
Human  2574 ILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINP 2638

  Fly  1325 --------DS------------------------------------------------------H 1327
                    ||                                                      .
Human  2639 VTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPED 2703

  Fly  1328 LP----------------------------------FTIKPASGVLKIGGQLDRELKDKYSFQVI 1358
            ||                                  |::.|.:||:|:...:|.|....|...|:
Human  2704 LPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVM 2768

  Fly  1359 A--TDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDR 1421
            |  ..|..|:    |.|.|.:.|.|:|||||.|               .||      .|||.|..
Human  2769 AHCLQNTDVV----SLVSVNIQVGDVNDNRPVF---------------EAD------PYKAVLTE 2808

  Fly  1422 STQPGTFVRQLTAIDKDNVGNGNGLVLYSIR-------HQEMQAPLFQIDSRDGTISTISRINGY 1479
            :...||.|.|:||||||.  ..:|.|.|.:.       |:     ||.|||..|.|:|:..:: .
Human  2809 NMPVGTSVIQVTAIDKDT--GRDGQVSYRLSADPGSNVHE-----LFAIDSESGWITTLQELD-C 2865

  Fly  1480 NDYEHLNVSVIASDVGSP-ALSATAIVIVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLT 1543
            ...:..:..|:|.|.|.. .||:.|:|.|     ::||...:.|:         |....|...:.
Human  2866 ETCQTYHFHVVAYDHGQTIQLSSQALVQV-----SITDENDNAPR---------FASEEYRGSVV 2916

  Fly  1544 ENNEAPIEVMRL--NLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNM----LLYALKPFDR 1602
            ||:| |.|::..  .|.|.::.:|.:.:.::.||      .|..::....:    .:.:.|..||
Human  2917 ENSE-PGELVATLKTLDADISEQNRQVTCYITEG------DPLGQFGISQVGDEWRISSRKTLDR 2974

  Fly  1603 EHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAP---KFRGNG 1664
            ||.::|.||:.|.    :.:..|.|:                 :.:.:.|.|||:|   :....|
Human  2975 EHTAKYLLRVTAS----DGKFQASVT-----------------VEIFVLDVNDNSPQCSQLLYTG 3018

  Fly  1665 QPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPARLFGIDELSGNIRLLGELSR-TE 1728
            :....|.|     |:.:.:|.|.|||...||:|.|.|....|..|.:|..:|.:..|..|.| .:
Human  3019 KVHEDVFP-----GHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERK 3078

  Fly  1729 HIYGFDVKATDRMGADDGRSGIVNVFVYI--INE 1760
            .::....||||    ..|||...::.:::  :|:
Human  3079 DVFNLVAKATD----GGGRSCQADITLHVEDVND 3108

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 27/106 (25%)
Cadherin_repeat 325..407 CDD:206637 19/82 (23%)
Cadherin_repeat 416..524 CDD:206637 31/108 (29%)
Cadherin_repeat 534..626 CDD:206637 26/125 (21%)
Cadherin_repeat 641..>714 CDD:206637 8/72 (11%)
CA 851..925 CDD:214520 24/76 (32%)
CA 1026..1085 CDD:214520 17/60 (28%)
Cadherin_repeat 1177..1280 CDD:206637 25/117 (21%)
Cadherin_repeat 1289..1385 CDD:206637 35/206 (17%)
Cadherin_repeat 1414..1510 CDD:206637 35/103 (34%)
CA 1576..1658 CDD:214520 16/85 (19%)
Cadherin_repeat 1666..1760 CDD:206637 27/96 (28%)
FAT2NP_001438.1 Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..659 CDD:206637
Cadherin_repeat 719..816 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1038..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1354..1444 CDD:206637 15/77 (19%)
Cadherin_repeat 1453..1551 CDD:206637 27/106 (25%)
Cadherin_repeat 1559..1650 CDD:206637 22/107 (21%)
Cadherin_repeat 1664..1754 CDD:206637 31/109 (28%)
Cadherin_repeat 1762..1867 CDD:206637 23/110 (21%)
Cadherin_repeat 1887..1963 CDD:206637 9/75 (12%)
Cadherin_repeat <1998..2066 CDD:206637 17/77 (22%)
Cadherin_repeat 2074..2163 CDD:206637 9/90 (10%)
Cadherin_repeat 2176..2268 CDD:206637 25/96 (26%)
Cadherin_repeat 2276..2375 CDD:206637 35/153 (23%)
Cadherin_repeat 2383..2475 CDD:206637 26/109 (24%)
Cadherin_repeat 2486..2581 CDD:206637 25/108 (23%)
Cadherin_repeat 2589..2682 CDD:206637 15/92 (16%)
Cadherin_repeat 2696..2793 CDD:206637 20/100 (20%)
Cadherin_repeat 2801..2902 CDD:206637 37/113 (33%)
Cadherin_repeat 2910..3007 CDD:206637 25/124 (20%)
Cadherin_repeat 3016..3109 CDD:206637 29/102 (28%)
Cadherin_repeat 3120..3209 CDD:206637
Cadherin_repeat 3224..3317 CDD:206637
Cadherin_repeat 3325..3422 CDD:206637
Cadherin_repeat 3431..3522 CDD:206637
Cadherin_repeat 3535..3619 CDD:206637
Laminin_G_2 3800..3921 CDD:280389
EGF_CA 3949..3984 CDD:238011
Cadherin_repeat 37..143 CDD:206637
Cadherin_repeat 152..247 CDD:206637
Cadherin_repeat 366..454 CDD:206637
EGF 3990..4020 CDD:278437
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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