Protein Alignment Cad89D and cdh-12

DIOPT Version :10

• Sequence 1: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Sequence 2: NP_001360600.1
• Gene: cdh-12 / 190583
• WormBaseID: WBGene00022103
• Length: 2893
• Species: Caenorhabditis elegans
• Alignment Length: 2472
• Identity: 484/2472 - (19%)
• Similarity: 863/2472 - (34%)
• Gaps: 828/2472 - (33%)

  Fly    17 KKKASQDMAVICVWVMPLAVFGLIAIGQAA-------KTGQVQASSGSCAFHTLDGVAAESEGVR 74
            ||::||:                  :|.|:       |..:.:|.|.:.....:||...|..|||
 Worm   617 KKQSSQE------------------VGGASRSEDKKTKEPEDEAESDTVTEKKVDGAGQEVGGVR 663

  Fly    75 ----------FIRLREDAQVGKEILRLQAYPRSTAA----LKGADASGDHKYFNLTEHNATTLVV 125
                      ....:|:.:..:||......|:|.|:    :.||:::..:|..:.:..|  .|.:
 Worm   664 PEVGGDNQEMGGASKENIEETEEIEEETEEPKSEASSQDKVGGANSNFQNKSTDKSLEN--QLNI 726

  Fly   126 SLARSLERL----------VDRDVPRNLLKFRILCAGKQEKLEEGSYLSITVYIEDVNDNAPEFL 180
            |.:.:.:.:          |.::..:.:||...  .|:.|.||.         :||..|  .|.:
 Worm   727 SESETSKEMGGATIQKVGGVKQENVKTILKAPE--TGESENLEN---------LEDSED--VEVV 778

  Fly   181 NVPYVVDVDENTSIESIIFEGVQ------------AFDRDKPNTPNSEVHFSMSTVPEQLSADGS 233
            .|...|:|:|:..:.....|.|:            ..|..:..|...|.    :||.|:..|..:
 Worm   779 TVIEEVEVEEDDDVIEDHVENVENDVRTTTASMSRTVDHQRTTTEEPEA----NTVEEEPPAPTT 839

  Fly   234 PYFALKSPHRPLLILKRELDFDNGIRQF----KLPIFAWDR------------------------ 270
            ..|:...|.........|:..::.|.:.    :...:|.||
 Worm   840 TVFSFPQPEYTYDAFGMEIQENDVIGKVAAGPRTEFYAVDREMIGLIKINEAGELLAGKKLNRHK 904

  Fly   271 ------------GTPANQANTTITINV-RDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIPLYFA 322
                        |....:|..|:..:. |||....|:|....||..|||..             .
 Worm   905 DGPLKFGVSATNGFETARAQVTVLRDANRDVMSAMPRFDRETYRFSINENQ-------------Q 956

  Fly   323 PPIMAFDQ-------DSLNASLVYDIISGN--ERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFV 378
            |.::.|.:       .|.:..|.|.:|:..  :...|.::..:|.:...:.:|.|::..
 Worm   957 PEVIGFVRAFHSAISSSESVRLTYSLIAPAHIDELPFEIHEQSGEVSTSRPLDTEQKKF------ 1015

  Fly   379 LQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGEN 443
            .:.:.|........:.:.:.|||:|:|||.|.|.......::..::|.|..::::.|.|.|.|.|
 Worm  1016 YRFQVRACLTQTICSTSDVIVEVVDVNDNPPIFTNRKLEATVESDVPPGTRIVKLFAKDADAGNN 1080

  Fly   444 SEFLYNLVETKDAAGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPG 508
            |...:.|:...:   .|.||..:|.:|..                 ::|.| |.|.....:...|
 Worm  1081 SRLSFALMSENE---PFSIDPNSGQLTTS-----------------QSLTR-PLYTILVSVSDAG 1124

  Fly   509 -PSK---VQVEITLLDTNDNTPKFEHGNLYEFKVPINAP--TGYVIGQVVAHDPDEGPNGHLLYE 567
             |.:   .:|.:.:..||.:.|.|:.   .|:|..|.||  .|.|||:|.|.|||.|..|.:.|:
 Worm  1125 VPQRSDTAEVTVVVKGTNPSPPAFDQ---KEYKAVIAAPIRAGQVIGEVRATDPDPGMEGLVTYK 1186

  Fly   568 LQRPKGSGYIPFRLDNKNGTIYVGGP--LRRGRIAVFVEATDQPTNPSERRFSLAVITIEVYATI 630
            |.|...:.:..|.:::|.|.|....|  |..|.|.:.:||||...|...:..:...|.|     |
 Worm  1187 LLRSDNNDHQKFMINSKTGVISAISPLSLEDGPIELGIEATDNGKNLKRKVKTNMKIDI-----I 1246

  Fly   631 DDQAIDFVGAPYEFWVGANTPLGTSVGQV-----------------RTTLIYEG----------- 667
            |.:.:.|:..|...::.....:|:.:.:|                 .:..:.:|
 Worm  1247 DSKTLKFLPLPTTVYISTEKAVGSVILRVSAVSTDNENIKFRALQENSQFVMDGDLLRVANHLVE 1311

  Fly   668 GDEIM---------------------------------YD------------------------L 675
            |:.|:                                 ||                        |
 Worm  1312 GESILSIRAETDTVHVDHQLKVIVMSDRDKYPVFPQLTYDFDVSTDGHFPRIVHQFNAKLGAGTL 1376

  Fly   676 LHTYSEGVP----FAIEERSGIITVIRELSEFKRK-----VYQFEAVANYLFANSSQSLVMSRSS 731
            .:|:....|    |.:::::|.:.|..:..|.||:     |......||..:::...::....::
 Worm  1377 RYTFFPPSPAPAGFYLDDKTGELFVTSQYPETKRETVFVVVRAVNMQANKFYSDVGVAITPVSTT 1441

  Fly   732 SP---------------------------LTTIASPAELS---DEGVL--ITNLTIHIVNK---- 760
            :|                           :|...|||:||   |...|  ..|.|:.:..|
 Worm  1442 NPTLRFQQPNYNFEVYESLGEGEAIGTISVTGSTSPAKLSLSPDTSFLGIHQNGTLFLAQKVDAE 1506

  Fly   761 --------------------PEQ-----KVPLRPVIE---EINMNVIHFHVEENVV--GGIIG-- 793
                                ||.     .|.:|.|.|   |.:.:.:.|.:|..|.  |..||
 Worm  1507 EIESLSQEFTVLAESSGKENPETARALIHVAIRDVNEFQPEFDEDDVEFSLERGVATPGATIGRV 1571

  Fly   794 -----------QLLYK--------------NGINLVNNEL------------------GTYRE-- 813
                       :|:|:              :|..:|.:|.                  |.:..
 Worm  1572 QAHDQDVSEKNRLIYRVVGGSGRKLVFIQEDGTIIVGDEQIPAAVDEFDLIIEAVDRNGNHDSTH 1636

  Fly   814 -------------------MPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRYI 859
                               .|:||...|:|.|:....:.::.|..    :..|:||..:..|
 Worm  1637 VIVYIDGAPTSSTEEHEPLFPAEPLVWNVTEGTTQSFQLQTASDD----VIYRIVGGNDDGL--- 1694

  Fly   860 IANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNA 924
                      ..::..|.|..::.|||.:|.||.|.|..:.| |:...|.: .|||.....|.:|
 Worm  1695 ----------FELSSRGELKIVSELDRTRQKSYTLQVEAKKS-GVAKVAEV-TVNINPTISNAHA 1747

  Fly   925 PKFNALTYVGLINENCVVGTELSMNHAILIQDADEGP--------------------NAEFRVQL 969
            |||....|.|.:..:..:|..:....|.   |.|:.|                    ...::|.:
 Worm  1748 PKFTRDHYSGTVPLDAPIGFPIVTMEAF---DEDDDPVQYTFKGTGCADQLGIDNSGRVAYKVAM 1809

  Fly   970 Q---------------GDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQE 1019
            :               |::|.|..:..:...:.|..|..|.|:....|::...|      |...:
 Worm  1810 KDRTTGSLECTVVVSDGEHSAETMLTLLVQENEEVETPQKPPNHAPTFSMAEYT------FTIPQ 1868

  Fly  1020 LHT---TFMQT-------NFKLSSGPY---FRISYTGK---RGLDREKQQLYNLKIIAADTGG-- 1066
            ..|   |.|.|       :|.:....|   |.:..:|:   ||  ..:||.|:..::|.|.|.
 Worm  1869 NSTDLGTVMATDPDGDLIDFSIEPTEYRNLFHVDSSGRIFVRG--PLEQQRYSFLVVAEDRGSPI 1931

  Fly  1067 LSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAP 1131
            ||.:.::.||                                   ||::.....|:|::
 Worm  1932 LSSFVNVKVL-----------------------------------VEATQEQLDPEASS------ 1955

  Fly  1132 PPYHIPGSP---RFNVDRERSVGAGLGVV--------------------ARAKSRRRMVRALT-- 1171
             |.|...|.   .:.|:....||:.:|.|                    ..:..|..:|:.||
 Worm  1956 -PQHFQFSQAVYSWRVESGLPVGSIVGFVKPVGVTDGISYSFISGDYLAIDSDGRVAVVKPLTET 2019

  Fly  1172 --------------TKCPLFAIYEDTPVGTKVL------QLSASDEDFGKNALLHYELQGEQVER 1216
                          .:..:|...|.:...|::|      |:.:::..    |......:.....|
 Worm  2020 VNDVVIAMKNGEILAETRIFVGVEPSEATTRILGPVTTTQVPSTEAP----ATSTQSSEESPSSR 2080

  Fly  1217 TPGMPML---------RVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRF 1272
            |..:|.|         |...:.....:.:|...:...|..|.|:    |....:.|
 Worm  2081 TSELPTLPPATPRITSRPSQLTLAPTEDISMVSTEQGPTLAPID----LPTRAVTG--------- 2132

  Fly  1273 TVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASG 1337
            .|:.:::...||....||..:.||::|..:..::.......|.:...::::.|:.|||.:.|...
 Worm  2133 RVIPLDSGRFTFTSPIYSAFSLEGDFKSGIELEIKPTLAVQGSSEPPSFSIEDTTLPFFLTPEGK 2197

  Fly  1338 VLKIGGQLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFI 1402
            ::..  :.|||..:.|.|.::|.     .|...:...:.|.:||:|||.|.|..:.|   ||..
 Worm  2198 LIMF--EADRERHESYLFTIVAK-----AQGQMARARLNVTILDVNDNYPRFQAHPD---AVGI- 2251

  Fly  1403 PSVADRTLML--PVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDS 1465
                .||:.|  |:|               ||.|:|.|...:..  |.||     :.:|...|||
 Worm  2252 ----SRTMHLGSPIY---------------QLKAVDLDKFPDNQ--VTYS-----LNSPWISIDS 2290

  Fly  1466 RDGTISTISRINGYNDY----EHLNVSVIASDVGSPALSATAIVIVNLQGQAVTDPPK--STP-- 1522
            |:|.:    |:||  |.    |.|:::|.|.|.|.|.|.:...:.:.:..|.:   ||  .||
 Worm  2291 REGLL----RVNG--DLQAAPESLDLTVEAQDSGKPPLKSETHLRILIFKQNI---PKFLETPLE 2346

  Fly  1523 ------KPEPPANV-------TVFQ------------HAYYEVKLTE---------NNEAPIEVM 1553
                  |..|.|::       ||.:            :..:|:|...         :|||..| .
 Worm  2347 VTQIPTKMAPGAHIKTLLAGPTVSEQDTILYRLVDTVNGLFEIKHAGELVLARRPLDNEAGRE-Y 2410

  Fly  1554 RLNLSAGLNPENYRWSLWL-----EEG-----------------------LDETDAH-------- 1582
            :||::|    ||.:.:.|:     .||                       ::.:.||
 Worm  2411 QLNVTA----ENSKGTDWVVLPIFVEGRLSSTNTPSTSCQFQQKVYRAQVMENSGAHDAVVRVQA 2471

  Fly  1583 --------------PPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVD 1633
                          ..||.|:::..:|..:|.|||..|.|.|.:.....:|:.::         |
 Worm  2472 GCQKKFRYAFHTQSKEFEIDSQSGQIYTTEPLDRETKSTYFLTVNVIEQNRKRQS---------D 2527

  Fly  1634 ERIEGLSLN----ECRILVHIADENDNAPKFRG--NGQPIVAVLPQSASFGYPVTRVEANDLDEG 1692
            .::|.||..    :..::|.:.|:|||||.|..  ....:.||:.|:|:...|||.::|.|||.
 Worm  2528 VQVEQLSSKLSPWQTLVVVTVLDDNDNAPVFLHMLPDSTLAAVVDQNANLMSPVTHLQARDLDV- 2591

  Fly  1693 LNAEIRYRLLNEPARLFGIDELSGNIRLLGELSRT--EHIYGFDVKATDRMGADDGRSGI-VNVF 1754
            |...:::.|....|..|.::..:|.::|...|.::  ||   |:::||    ..||:..: |.:.
 Worm  2592 LPGNLKFELEGPEADSFFLNSTNGLVQLAKSLEKSDVEH---FELQAT----VTDGKHAVHVPLN 2649

  Fly  1755 VYIINEAKQVRLVVAGM------PVEVERRIEGLMEALSDAIGKDVRVRLLEPY---SGGLE-PA 1809
            :|:::....|..:....      |..|||:       |::.:|.|.|:.:.:|:   .|..: ..
 Worm  2650 IYVLSVDTNVVQLTKNTPHSDIDPSAVERK-------LTEILGMDTRILVAQPFVSDDGKTDMKK 2707

  Fly  1810 TNAYIYAVDPHTNSIMEMEQLQDALAGLQLDALQLQQQKLDGGKPMPRILELAEFGQLARPAHAS 1874
            ::.::|::|..:...:..::|:           :|.....||..|:          |::..:..|
 Worm  2708 SHVFVYSLDNLSQKPISRDELK-----------RLLMAHSDGLHPL----------QISSVSLLS 2751

  Fly  1875 ASSFMGGLEFVTVVLLALISLGALIAACCYVCMRQKRRLWSQRDFSASDAGL---TYTIAGIGS- 1935
            ..:..|..:|:..|:|.::.:..|:..|..:....|||       :.:.||:   .|.|..:||
 Worm  2752 TGNAAGNGQFLLTVVLLVVLIALLLFICALIMCCAKRR-------ARNTAGVMEGAYMINSVGSG 2809

  Fly  1936 PR 1937
            ||
 Worm  2810 PR 2811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	25/159 (16%)
		Cadherin_repeat	325..407	CDD:206637	15/90 (17%)
		Cadherin_repeat	416..524	CDD:206637	23/111 (21%)
		Cadherin_repeat	534..626	CDD:206637	34/95 (36%)
		Cadherin_repeat	641..>714	CDD:206637	18/166 (11%)
		CA	851..925	CDD:214520	18/73 (25%)
		CA	1026..1085	CDD:214520	17/73 (23%)
		Cadherin_repeat	1177..1280	CDD:206637	18/117 (15%)
		Cadherin_repeat	1289..1385	CDD:206637	22/95 (23%)
		Cadherin_repeat	1414..1510	CDD:206637	27/99 (27%)
		CA	1576..1658	CDD:214520	23/107 (21%)
		Cadherin_repeat	1666..1760	CDD:206637	27/96 (28%)
cdh-12	NP_001360600.1	Cadherin_repeat	385..479	CDD:206637
		Cadherin_repeat	487..576	CDD:206637
		Cadherin_repeat	946..1044	CDD:206637	21/116 (18%)
		Cadherin_repeat	1054..1142	CDD:206637	21/108 (19%)
		Cadherin_repeat	1152..1247	CDD:206637	34/99 (34%)
		Cadherin_repeat	1562..1641	CDD:206637	9/78 (12%)
		Cadherin_repeat	1677..1739	CDD:206637	20/80 (25%)
		myxo_dep_M36	<1723..1985	CDD:468355	61/316 (19%)
		Cadherin_repeat	1861..1943	CDD:206637	22/124 (18%)
		Cadherin_repeat	<2174..2238	CDD:206637	17/70 (24%)
		Cadherin_repeat	2251..2332	CDD:206637	31/113 (27%)
		Cadherin_repeat	2347..>2419	CDD:206637	15/76 (20%)
		Cadherin_repeat	2451..2554	CDD:206637	21/111 (19%)