DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and cdh-1

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_497641.2 Gene:cdh-1 / 187783 WormBaseID:WBGene00019994 Length:2779 Species:Caenorhabditis elegans


Alignment Length:2690 Identity:532/2690 - (19%)
Similarity:898/2690 - (33%) Gaps:900/2690 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 AVFGLIAIGQAAKTGQVQ--ASSGSCAFHT-------------LDGVAAESEGVRFIRLREDAQV 84
            ::...::|.|..:..:::  .||..|...|             ||...|....::|: |.:|.|:
 Worm   358 SIVARVSIAQQYRDTKLRLIGSSALCPQQTDQAHVYLLLLCGILDRETASEHHLKFL-LEKDGQI 421

  Fly    85 GKEILRLQAYPRSTAALKGADASGDHKYFNLTEHNATTL---------------------VVSLA 128
            ..|..:|..............:|..|...|.|:..:.||                     :||:.
 Worm   422 IIEHPQLLTIGDINDNAPQWHSSQIHISLNRTQGGSRTLTAKDPDLGQNGWIRYSVLDTELVSID 486

  Fly   129 RSLERL-VDRDVPRNL---LKFRILCAGKQEKLEEG------SYLSITVYIEDVNDNAPEFLNVP 183
            :...|: |...:..|:   :|||:       :.|:|      :.|.:...:.|.....|:|....
 Worm   487 KETGRIFVPNTIDCNIGSEIKFRV-------RAEDGGSPALSTDLQVVADLLDTESKPPQFEKAL 544

  Fly   184 YVVDVDENTSIESIIFEGV-----------------------------------QAFDRDKPNT- 212
            :.|::.|:|.|.:.:.:.|                                   :.||.:|..: 
 Worm   545 WQVEIPEDTPIGTCLVKVVANNSQCGNSKRIRYSLQNQDEHLTVDTMSGTVCIQKTFDFEKQKSY 609

  Fly   213 --------PNSEVHFSMSTVPEQLSADGSPYFALK----------SPHRPLLILKRELDFDNGI- 258
                    .|||...|:.::..:...|..|.|...          .|..|||::... |.|:|. 
 Worm   610 QTTVIATNANSETSTSLISIRLKDVNDNWPIFYPNEYHLTVREGPKPEEPLLVVSAS-DMDSGTF 673

  Fly   259 -------------------------------RQFKLPIFAWDRGTPANQANTTITINVRDVDDLP 292
                                           .:|.|.:.|.|.|..:::.:..|.|.|.|.|...
 Worm   674 GEVSYHILSESSSFSINPVTGEVFAQKPLARGRFHLVVSAKDGGGQSSENSANIHITVIDKDTKT 738

  Fly   293 PKFTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQDSLNA--SLVYDIISGNERQLFRVNPH 355
            |:|:...|..|..|.. :.|:.|               .|:.|  .:.|.|.||::...|.::..
 Worm   739 PQFSRSKYEIRTTEDI-LPGIAI---------------GSVGAMSKVKYSIYSGDQDHNFSIDED 787

  Fly   356 NGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNISI 420
            .|.:|:.:.:|.:..    :|.:|.::|........:....|.:|  |.|||.|:|.:....|||
 Worm   788 TGKIYVTRYLDADVH----DTVLLNIQATLPSGESNQTQVVIFIE--DHNDNPPQFSSSLVEISI 846

  Fly   421 VENLPTGFSVLQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRTGWITVRDDRLLDREQRRSI 485
            .|:|........|.|.|:|:.:|.|..|:::.:...: :..||..||.::.  ..|||.|..|:.
 Worm   847 REDLKLHEPFYVVQASDKDKKKNGEVRYSIISSHPGS-SIEIDQFTGQLST--GSLLDYEATRNY 908

  Fly   486 QLNVEALERN-PSYLDDKHLKKPGPSKVQVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIG 549
            :|.|:|.:.. |          |..|.:.:.|.:||.|||.|:||. :.|..:|..|:|...::|
 Worm   909 KLRVKATDLGIP----------PRSSNMTLFIHVLDVNDNAPEFEK-SWYTMEVLENSPPKTIVG 962

  Fly   550 QVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNGTIYVGGPLRR---GRIAVFVEATDQPTN 611
            :|||.|.|...||.::|.:  ..||.|  |.:|.|.|.:|....:.|   ..:.:.:.|.|:...
 Worm   963 KVVARDKDSLENGQIVYRI--TNGSEY--FGIDEKLGNVYTKRSIDREVISHVDISIVAEDKGVP 1023

  Fly   612 PSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVGQV---------RTTLIYEG 667
            |   |.|.|...|.|....|:........|  ..|.|.:||.|::|.:         ..:::|..
 Worm  1024 P---RSSTASARISVLDVNDNPPSCLSITP--IVVPAGSPLSTAIGTIVAMDPDKGLNGSVLYRA 1083

  Fly   668 GDEIMYDLLHTYSEGVPF------AIEERSGIITVIRELSEFKRK-------VYQFEAVANYLFA 719
              ::...|....|.|..:      |.:||...::||.......||       |...:..|:....
 Worm  1084 --QLQSSLFVVKSNGDVYLRRQLNASDERHQRLSVIVSDQGVPRKSVVCHVPVRISKGSADIQIQ 1146

  Fly   720 NSSQSLVMSRSSSP----LTT---------IASPAELSD-----EGVLITNLTIHIVNKP----- 761
            ...|..:....|.|    |||         :...:|:|:     ||||.  :..|.:::|     
 Worm  1147 EPFQKYIEIPKSCPTGCRLTTLNATGVSSWLIQSSEISNHFAIREGVLF--MISHPIHRPPYSLV 1209

  Fly   762 ---------EQKVPLRPVI--------EEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELG 809
                     ::.:.||.:.        |.|.::      :.|.:|..||:|..|:..........
 Worm  1210 IVLSDKNDRQKSIQLRVLASGEAANKEETIRIS------DSNSIGTKIGRLGEKSADGSFFYRFS 1268

  Fly   810 TYREMPSEPTSR-------------------------NITMGSRFRSRNRSRSSKSKRRLPRRLV 849
            :....|.|....                         |.|.||....|.....|::|...||...
 Worm  1269 SEESCPLELDQTGGLLYLADGLRRGDTHNFSCFFEKFNTTDGSAEEMRVDLEISRTKSDKPRFDT 1333

  Fly   850 GDANIKLR------YIIANQQE----------------VVNKISITE-DGTLLTLTGLDREQQPS 891
            |...:.:|      .||.....                :::..||.: .|.:..:..|.....|:
 Worm  1334 GHLRVNIREDTPTGSIITTVNATVSDDSASPISYRFPLLIDNFSIDQFTGDITLIDTLHWHVTPT 1398

  Fly   892 YELTVIVEYSTGLVSGAG-IYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQ 955
            |.|  |||..|   ||.| ...|.:.||||||:.| |.......|:..:...|   .|.|.::..
 Worm  1399 YNL--IVEAFT---SGPGTTLLVTVNVDDVNDHTP-FIVSQPTVLLPSSYRKG---GMVHRVVAI 1454

  Fly   956 DADEGPNAEFRVQLQG-DYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQE 1019
            |.|:.|...:.::..| :.:.||                                     ||..|
 Worm  1455 DLDKDPEIRYSLKYAGSEVAKEF-------------------------------------FKIDE 1482

  Fly  1020 LHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNA 1084
                        .||..|.:.               :...::...||......||:...|:.|..
 Worm  1483 ------------KSGEIFVVE---------------SSSALSTSFGGAGLPETLTIRATDLQDLT 1520

  Fly  1085 PMFERISVFKDSRLE------IREYTTDMEIYFVESSSGMTAPQATAAMML----APPPYHIPGS 1139
            ...|:..:.|.|...      ..|...|:.|.       .|:||.:..:.|    ......||.|
 Worm  1521 KFDEQKVLLKASNASRSTWHFFDEQHKDVTIL-------STSPQGSQILQLKFQEGVDLQLIPSS 1578

  Fly  1140 PRFN------VDRERSVGAG---LGVVARA------KSRRRMVRALTTKCPLFAIYEDTPVGTKV 1189
            |.|.      |.:..||..|   ..:||:.      .:.:..|..:.|:.|..:   .|..|...
 Worm  1579 PHFELKSSKIVQKSASVATGTQRFTIVAQKDDELDYSTLKIHVEPVFTEPPKIS---STSCGVVT 1640

  Fly  1190 LQLSASDEDF------GKNALLHYELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPL-- 1246
            ::.:...|||      |......:..||...:               |:|:..:|.:|| .||  
 Worm  1641 IEENVGIEDFKRILATGMTEESRFRFQGNAPK---------------FSINSTTGSISV-LPLDR 1689

  Fly  1247 SANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYS-FDTPEGEYKDSVLGQLTAID 1310
            .|:.|.:|.:.:||.....||..:|.||.|.|::.|....|..| .:..|......||.:..|.|
 Worm  1690 EASQEHLLIIILTDGGSRNDSCTVRVTVADQNDNKPQLDASTPSELEIAESSRVGDVLHRFRASD 1754

  Fly  1311 MDFGEN----------------------------------------------------------- 1316
            ||.|:|                                                           
 Worm  1755 MDIGQNGKFSFELLEDSSGSLDLVPETGDLVLRRLSSLQSWKIKLRVVDHGVPGLYVEKNLEISN 1819

  Fly  1317 ---------------------------------------ANITYTLSDSHL--PFTIKPASGVLK 1340
                                                   |.:||::.:.::  .|:: .:.||::
 Worm  1820 RNPQTEAKAPLEFLKQTYLSTIDEGLPRGQFIAKLQPELAGLTYSIVEGNIDSAFSV-DSEGVIR 1883

  Fly  1341 IGGQLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEF---------------- 1389
            ...:||||:.::||.:||.|.:.   |::.:.|||.||  ::|||.|.|                
 Worm  1884 TNLELDREILERYSLKVIGTGSG---QQIGTRVDVRVN--NLNDNVPSFPMSKPRRVPENLRVGS 1943

  Fly  1390 ----IG----------------------------------------------------------- 1391
                :|                                                           
 Worm  1944 YVATVGAKDVDNLAPLRYFLVSDSSGQTPTHFNIDQFTGTIHLTAPLDFEVLPEHTLTIKATDGS 2008

  Fly  1392 YDDQTKAVKFIPSVADR--TLMLPVYKAYLDRST-QPGTFVRQLTAIDKDNVGNGNGLVLYSIRH 1453
            :|..|....|:..:.|.  |...|:|:..:..:| .||....::.|.|.|    ..|.:.||:  
 Worm  2009 FDTFTNLTIFVSDINDNAPTFSKPLYQTTVSPATFSPGQPFAKIEAHDLD----ARGALTYSL-- 2067

  Fly  1454 QEMQAPLFQIDSRDGTI-STISRINGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQGQAVTDP 1517
            .:..:.:|::....|.: ..:....|    |...|:|.|:|.|.|:.| |::.:..:.|:|    
 Worm  2068 GQGSSSIFRVAPESGALFMKVLPPAG----ERYLVTVTATDNGVPSFS-TSVPVSVIIGEA---- 2123

  Fly  1518 PKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPE-NYRWSLWLEEGLDETDA 1581
             :.|.||.       |:.|.:..::.||::..:::.  |||...:.| :||        :.:.:|
 Worm  2124 -EPTDKPG-------FEKAEFRFEVMENSKIGLQIG--NLSGEESREFHYR--------IQDPEA 2170

  Fly  1582 HPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRI 1646
            ...|..| |...|:...|.|||..:.::.::..|       |....|..|           :|:.
 Worm  2171 SKIFSID-KFGRLFVAGPIDREQRATHEFQVEID-------NEMMTSQKV-----------QCKC 2216

  Fly  1647 LVHIADENDNAPKFRGNGQPIVAV---LPQSASFGYPVTRVEANDLDEGLNAEIRYRLLN-EPAR 1707
            .|.:.|||||.|.|..     ||.   |..|.:.|..:.::.|:|.|.|.|..:.||:|: ....
 Worm  2217 HVIVLDENDNLPVFTS-----VAYYLSLKDSMAHGQKIGQIMASDQDSGENGRVSYRILSGNDLN 2276

  Fly  1708 LFGIDELSGNIRL-------LGEL-SRTEHIYGFDVKATD----------------RMGADDGRS 1748
            :..::..:|:|:|       |.|. :.|..|.   |:|.|                :|.:..|.:
 Worm  2277 IVTLNPDTGSIQLNEWNDAQLDEFPNATWQIL---VEARDHGHPARAAVGKVQVSLKMSSWSGSA 2338

  Fly  1749 GIVNVFVYIINEAKQVRLVVAGMPVEVERRI----EGLMEALSDAIGK---DVRVRLLEPYSGGL 1806
            ....:.||.::..:...:......:....|:    :||:.:|.:..||   ||:       :|.|
 Worm  2339 PFFVLPVYEVHVLEDTSVGTVLQKIRASNRLGMRNDGLLYSLKEHQGKLGIDVK-------TGEL 2396

  Fly  1807 ----------EPATNAYI---------------YAVDP-------HTNSIMEMEQLQDALAGLQL 1839
                      ||..:.|:               ..|:|       .|.|...::......||..:
 Worm  2397 TLKTHLDWESEPIISMYLSVSDGNGRSAVVPLKIVVEPVDEFAPVFTKSSYTLQIPISTPAGESV 2461

  Fly  1840 DALQLQQQKLDGG----------------------------KPM--PRILELAEFGQLARPAHAS 1874
            .  |:|....|||                            ||:  .|.|.:.:...:|..:...
 Worm  2462 G--QMQAIDEDGGVHGVVKYSISDRQSTVKIEEHTGIIRLQKPLVSRRNLTIEQITVVAYSSPTK 2524

  Fly  1875 ASSFMGGLEF------------------VTVVLLALISLGALIAACCYVCMRQKRRLWSQRDFSA 1921
            .|.....||.                  |.:.:.:||.|..|:.....:||.:.||         
 Worm  2525 QSKTTVYLEIGPFDVQPSLPKLLLHSKPVQIAVASLILLLFLLIVVICICMCKSRR--------- 2580

  Fly  1922 SDAGLTYTIAGIGSPRGQKQRRQRQQRHTQ--RCSKGSTGSQRPTSAFMPESVCSSAQTQSTATA 1984
                              |.:.:::::|..  ..::....||:||.    :....|.:|....|.
 Worm  2581 ------------------KTQNEKEKKHPDVIVTAERRPSSQKPTL----QKQVYSVKTGEIRTL 2623

  Fly  1985 TEKLEQQLHHHHQQQAM----ATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVTSGGDGAV 2045
            :   :.|.||||...:|    :|.....:.:....|.|....||   |.:::..::||   |..|
 Worm  2624 S---DAQHHHHHPTHSMTSSVSTSSDALRMVRGSSRSQMDSGID---PDNVSINSSVT---DYLV 2679

  Fly  2046 GVGSTPFVLKYNACQPVNNLNNYETSLFSLHSTGQDSGVEFLSSR--ELYETSPDSFQHGGSKRG 2108
            .:|     :..|...|....|....||.:          |::.:|  ::....|.|         
 Worm  2680 SLG-----VNANPIPPRIRPNTTYDSLMN----------EYIYARVEDVLPPGPIS--------- 2720

  Fly  2109 NNTEVLCPRHAKAHLELRQPNTDSS 2133
                :..|..   |..||||.:.||
 Worm  2721 ----LTTPNQ---HSLLRQPLSTSS 2738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 31/192 (16%)
Cadherin_repeat 325..407 CDD:206637 17/83 (20%)
Cadherin_repeat 416..524 CDD:206637 31/108 (29%)
Cadherin_repeat 534..626 CDD:206637 29/94 (31%)
Cadherin_repeat 641..>714 CDD:206637 19/94 (20%)
CA 851..925 CDD:214520 24/97 (25%)
CA 1026..1085 CDD:214520 9/58 (16%)
Cadherin_repeat 1177..1280 CDD:206637 27/110 (25%)
Cadherin_repeat 1289..1385 CDD:206637 32/196 (16%)
Cadherin_repeat 1414..1510 CDD:206637 22/97 (23%)
CA 1576..1658 CDD:214520 20/81 (25%)
Cadherin_repeat 1666..1760 CDD:206637 27/121 (22%)
cdh-1NP_497641.2 Cadherin_repeat 29..118 CDD:206637
Cadherin_repeat 129..229 CDD:206637
Cadherin_repeat 238..328 CDD:206637
Cadherin_repeat 459..532 CDD:206637 13/79 (16%)
Cadherin_repeat 546..637 CDD:206637 12/90 (13%)
Cadherin_repeat 645..733 CDD:206637 15/88 (17%)
Cadherin_repeat 746..833 CDD:206637 22/108 (20%)
Cadherin_repeat 843..938 CDD:206637 31/107 (29%)
Cadherin_repeat 947..1041 CDD:206637 30/100 (30%)
Cadherin_repeat 1051..1136 CDD:206637 18/86 (21%)
Cadherin_repeat 1337..1426 CDD:206637 23/93 (25%)
Cadherin_repeat 1445..>1515 CDD:206637 19/136 (14%)
Cadherin_repeat 1638..1723 CDD:206637 25/100 (25%)
Cadherin_repeat 1734..1817 CDD:206637 9/82 (11%)
Cadherin_repeat 1836..1923 CDD:206637 22/92 (24%)
Cadherin_repeat 1934..2025 CDD:206637 4/90 (4%)
Cadherin_repeat 2034..2120 CDD:206637 22/96 (23%)
Cadherin_repeat 2135..2226 CDD:206637 26/119 (22%)
Cadherin_repeat 2235..2330 CDD:206637 21/97 (22%)
Cadherin_repeat 2345..2437 CDD:206637 17/98 (17%)
Cadherin_repeat 2446..2534 CDD:206637 14/89 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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