DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and cdh-8

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_001294412.1 Gene:cdh-8 / 184652 WormBaseID:WBGene00017576 Length:1684 Species:Caenorhabditis elegans


Alignment Length:1996 Identity:404/1996 - (20%)
Similarity:665/1996 - (33%) Gaps:723/1996 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   341 IISGNERQLF---RVNPHNGVMYLQKEIDLEEES---LPGNTFVLQLEARQKDNPLKKALARIEV 399
            |:||:....|   ::|.....:.|...:|.::|:   |.|.:|.|.:...      ||:.|.:||
 Worm    55 ILSGDPASYFTVVKINETCSTLQLNLALDADKENADGLRGQSFSLVIAGP------KKSRATLEV 113

  Fly   400 EVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRD-----------QGENSEFLYNLVET 453
            :::|:|||.|:|.....:..|.||...|..:.:|..:|.|           :|::|   :.|.:.
 Worm   114 QIVDVNDNSPQFSNTPSSFEISENAEIGTDIFKVTTLDPDTGISGISRFSVEGDSS---FTLAKR 175

  Fly   454 KDAAGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITL 518
            |.::|......|..       :.||.|::.....|:.|.:.:|      |..:.......|.|.:
 Worm   176 KCSSGKCSTQLRLA-------KKLDFEEKPIHTFNITAKDGDP------HSNRTHTVAHTVTIHV 227

  Fly   519 LDTNDNTPKFEHGNLYEFK--VPINAPT--GYVIGQVVAHDPDEG--------PNGHLLYELQRP 571
            .:.||..|||    |.:|.  .||...|  |.:|.::.|.|.:.|        .|.||       
 Worm   228 KNENDEPPKF----LTDFSQVFPIFKSTKPGDIIAKLEAIDVENGAEIQFGMKENEHL------- 281

  Fly   572 KGSGYIPFRLDNKNGTIYVGGPLRRGRIAVFVEATDQPTNPSERRFSLAVITIEVYAT------- 629
                    ::|:|:|.:.:               ...||:.       |:||:|:|||       
 Worm   282 --------KIDSKSGNVLL---------------KKLPTDD-------ALITVELYATSSKNGKS 316

  Fly   630 ---------IDDQAI-----------DFVGAP-YEFWV----GA-NTPLG----TSVGQVRTTLI 664
                     ::|:|.           :....| ||..:    |. :|||.    .|:.:.:..||
 Worm   317 KTVEMKLRLMNDEATLPKIAENQEKPELCEFPIYEAHLIQGTGTFSTPLKIKTLKSMAEEKPRLI 381

  Fly   665 YEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQSLVMSR 729
              ||.| .:||                   .||.:. ..:.||...|.||:.:. :|:|.||.|:
 Worm   382 --GGSE-SFDL-------------------NVIDDF-HVELKVLNAEKVASQVL-DSAQLLVKSQ 422

  Fly   730 SSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRPVIEEINMNVIHFHVEENVVGGIIGQ 794
            |......:.|.|:::.:...|.           ||:.:.|..|:   :...|.|.||....::|:
 Worm   423 SGQCRIVLRSAAQMTPKASPIA-----------QKLKIIPKFEK---SEYQFQVVENREPTVLGE 473

  Fly   795 LLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRYI 859
            :                                                   :::.|..:....:
 Worm   474 V---------------------------------------------------KVISDGPVTYEIL 487

  Fly   860 IANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNA 924
            ..|.:    |..|:.||.:..|..:|||....:||.|   .:|.|...:|..|:.|.|.|.|||:
 Worm   488 GENGE----KFQISNDGEIQNLEPIDRETYEKFELIV---KATDLNGSSGKSQLIIHVKDENDNS 545

  Fly   925 PKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSEN 989
            |.|:...|...::|.      .|....|...|||.|.|.:.                        
 Worm   546 PIFDKEHYFITVDEG------KSEKLKITATDADSGKNGQI------------------------ 580

  Fly   990 STHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDRE---K 1051
                          :::: ||..|              |..:...|...: :.|  .:|||   .
 Worm   581 --------------VYSI-DQKID--------------NLPIDISPDGML-FIG--AIDRENMGN 613

  Fly  1052 QQLYNLKIIAADTG--GLSGYAHLTVLVADVNDNAPMF--ERISVFKDS---------RLEIREY 1103
            ....||.:.|:|:|  ..|..|.:|:.|.|:|||:|:|  .|.|:..|:         |||..:.
 Worm   614 SNEVNLTVTASDSGEPKRSASATVTIRVKDINDNSPVFSNSRYSIPLDANISPGGIIGRLEATDA 678

  Fly  1104 TTDMEIYFVESSSG---MTAPQATAAMMLAPPPYHIPGSPRFNV------DRERSVGAGLGVVAR 1159
            .:.....:|..:||   .|...:...:...|.......|..|||      |...|..| |.|:..
 Worm   679 DSTSPNNYVTYTSGDPKFTVSDSGEILFTGPGTLEKSASLEFNVTAQDGGDPMNSANA-LVVINE 742

  Fly  1160 AKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVE---RTPGMP 1221
            .:|.:.:...|||                  |::::|..            ||:.|   ...|||
 Worm   743 HRSMKSIENELTT------------------QINSNDTG------------GEKSEIKWLNAGMP 777

  Fly  1222 -----MLRVHG--------VKYFAIDKLSG-------------------------------ELSV 1242
                 ::|...        ..:.:||..||                               ||.:
 Worm   778 GYTYEIIRASADGFSDSEVATWISIDSKSGRIYTLKKVDPSRVKQIKLHISMRKGKREVPVELII 842

  Fly  1243 NY---------------PLSANIEIMLNLTVTD--IDGLKDSTCLRF------------------ 1272
            |.               .||......|..||.|  ::|:|:...:::                  
 Worm   843 NVMDTDDVTPIYSTPTRKLSVTESATLGTTVVDMPVEGIKEQNEIKYSLKITSGPRGKLQIDRYG 907

  Fly  1273 -------------------------------------TVMDVNNHAPTFKKSWYSFDTPEGEYKD 1300
                                                 |::|.|::.|.||.   |.:......:.
 Worm   908 TIKIIKSLDFETEQIIKGIVEGMVVKNGKAAKSSFILTILDANDNRPIFKN---SSNFAVSLLES 969

  Fly  1301 SVLGQL------TAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVIA 1359
            ||||.:      .|.|.|..:.:.:.|:::.....|.|..::..:::...||.|.:..:|..:..
 Worm   970 SVLGTVLDLPYPLATDRDSSKFSTLKYSMTGDEGYFKIDESNSTIRLVAPLDFETQRVHSLSIKC 1034

  Fly  1360 TDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQ 1424
            .||............|.|.|:|:|||.|.....|                    :....::...|
 Worm  1035 VDNQGREPHHEVFASVTVTVIDVNDNAPVIHNTD--------------------LTHLSIEEDAQ 1079

  Fly  1425 PGTFVRQLTAIDKDNVGNGNGLVLYSIRHQE--MQAPLFQIDSRDGTISTISRINGYNDYEHLNV 1487
            .|..|..|...|.|..|         ::..|  :.:.||:.|| |..:..|:.:.|:.. :.:..
 Worm  1080 VGQVVTVLVISDSDEGG---------VQKTEIDVNSTLFRADS-DKKLVVIASLKGHAG-QRICS 1133

  Fly  1488 SVIASDVGSPALSATAIVIVNLQGQAVT--DPPKSTPKPE------------------------P 1526
            :|.|:|||  .|.||:...|.:.....|  :|...|||..                        .
 Worm  1134 TVTATDVG--GLRATSPYCVTVYPAKNTHHNPLVITPKQNSIHYFDENIVYDELLKVKVLEEDGD 1196

  Fly  1527 PANVT-----VFQHAYYEVKLTENN-----------------EAPIEVMRLN------LSAGLNP 1563
            ..|||     :|:..:....:.|.|                 |..|...|:|      |...:|.
 Worm  1197 IGNVTFRLDEMFKKDWQMFTIGEINGSLHARQAFDFEKKTVHEIKILACRINNCTSTHLFISVND 1261

  Fly  1564 ENYRWSLWLEEGLD--------------------ETDAH------------PPFEY-DAKNMLLY 1595
            .|....::.::.:.                    ::|.|            |.|.: |....:|:
 Worm  1262 RNDNCPMFPKQDVRLTVLENEKGKRQVGRIPAALDSDFHSDNTKVCYTTDTPLFFFSDPTLPILF 1326

  Fly  1596 ALKPFDREHISRYQLRIRADRLSREARN-YARVSYPVVDERIEGLSLNECRILVHIADENDNAPK 1659
            ....|||||..::|:.|.|.......|: :..::..:|             .|:.:.|.|||.||
 Worm  1327 TNSSFDREHKKQHQISITAYDCHLSCRDPHKPINGTIV-------------ALIDVLDINDNFPK 1378

  Fly  1660 FRGNGQPIV--AVLPQSASFGYPVTRVEANDLD---EGLNAEIRYRLLNEPARLFGIDELSGNI- 1718
            |   .:.|.  .|:....:.|..:..|:|.|||   |||...|| ..:..|:..|...|...:| 
 Worm  1379 F---SEKIYTSTVVQGHVTTGSHILTVQATDLDEEPEGLKYSIR-GFVRSPSHSFVAAESPISID 1439

  Fly  1719 RLLGELSRTEHI----YGFDVKATDRMGADDGRSGIVNVFVY-----------IINEAKQVRLVV 1768
            :..||||.||.:    |.|.|..||..|.:|..|.:|....|           ::..|:|..||.
 Worm  1440 KSTGELSATEILKDSSYSFTVVVTDGAGHEDTASVVVIDLSYELSTNASFQISVVTYAQQTELVF 1504

  Fly  1769 AGMPVEV----ERRIEGLMEALSDAIGKD--------------VRVRLLEPYSGGLEPATNAYIY 1815
             ..|.|:    |::|   .|.||:|.|..              :.|..::         .|....
 Worm  1505 -DAPFELIMKNEKKI---AENLSNATGLQTIVDKCRQNANFTLMLVHFMD---------INGQFV 1556

  Fly  1816 AVDPHTNSIM----EMEQLQDALAGLQLDALQLQQQKLDGGKPMPRILELAEFGQLARPAHASAS 1876
            .||...|.:|    |..:...::.||:           :...|:|...::.::            
 Worm  1557 NVDRAVNLLMSSSAESRRELRSVYGLR-----------EAFPPVPIPSKVPQY------------ 1598

  Fly  1877 SFMGGLEFVTVVLLALISLGALIAACCYVCMRQKRRLWSQRDFSASDAGLTYTIAGIGSPRGQKQ 1941
                  ..:.|:|..:||    |.:.|..| ||:.....:....::.|...:|:. :|  ||.| 
 Worm  1599 ------ILIAVLLFFVIS----ILSMCIWC-RQRNNYERKLRHISAQASTVHTVT-LG--RGGK- 1648

  Fly  1942 RRQRQQRHTQRCSKG------STGSQRPTSAFMPESVCSSAQTQST 1981
                     |.|:.|      .:....|..|..|.   :||..|||
 Worm  1649 ---------QTCNPGYGEIPIISRHHHPPPAPPPP---TSADLQST 1682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637
Cadherin_repeat 325..407 CDD:206637 19/71 (27%)
Cadherin_repeat 416..524 CDD:206637 23/118 (19%)
Cadherin_repeat 534..626 CDD:206637 20/103 (19%)
Cadherin_repeat 641..>714 CDD:206637 20/82 (24%)
CA 851..925 CDD:214520 23/73 (32%)
CA 1026..1085 CDD:214520 19/63 (30%)
Cadherin_repeat 1177..1280 CDD:206637 27/221 (12%)
Cadherin_repeat 1289..1385 CDD:206637 22/101 (22%)
Cadherin_repeat 1414..1510 CDD:206637 24/97 (25%)
CA 1576..1658 CDD:214520 21/115 (18%)
Cadherin_repeat 1666..1760 CDD:206637 33/114 (29%)
cdh-8NP_001294412.1 Cadherin_repeat <55..121 CDD:206637 19/71 (27%)
Cadherin_repeat 131..232 CDD:206637 22/116 (19%)
Cadherin_repeat 457..544 CDD:206637 26/144 (18%)
Cadherin_repeat 552..647 CDD:206637 29/156 (19%)
Cadherin_repeat 656..741 CDD:206637 19/85 (22%)
Cadherin_repeat 861..952 CDD:206637 11/90 (12%)
Cadherin_repeat 964..1060 CDD:206637 21/95 (22%)
Cadherin_repeat 1184..1265 CDD:206637 13/80 (16%)
Cadherin_repeat 1275..1375 CDD:206637 19/112 (17%)
Cadherin_repeat 1396..1476 CDD:206637 29/80 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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