DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and cdh-5

DIOPT Version :10

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_001343640.1 Gene:cdh-5 / 177671 WormBaseID:WBGene00000397 Length:1449 Species:Caenorhabditis elegans


Alignment Length:1842 Identity:365/1842 - (19%)
Similarity:626/1842 - (33%) Gaps:549/1842 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 LQVNAVDRD-QGENSEFLYNLVETKDAAGAFRIDSRTGWITVRDDRL-LDREQRRSIQLNVEALE 493
            ||:...|.| |.......|..:.|...|..|.:|.| |::.:...:: .|.....:.||||||.|
 Worm    16 LQILVNDEDLQPGMPPATYQYILTGLGATIFAVDQR-GFVYLNVPKIDADPPNPSTYQLNVEARE 79

  Fly   494 RN--PSYLDDKHLKKPGPSKVQVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDP 556
            .|  |:       ::..|  |.:.|.:||.|||:|:||. .:|......:.....|: :|||.|.
 Worm    80 VNTVPT-------RRSEP--VTITIHILDINDNSPQFEQ-PIYMANTTASGDERDVV-KVVATDV 133

  Fly   557 DEGPNGHLLYELQRPKGSGYIPFRLDNKNGTIYVGGPLRRG-RIAVFVEATDQPTNPSERRFSLA 620
            |.|..|.:.|.:.:....|...||.:.....:...|.|..| |..|.:||.|     ...|.|.|
 Worm   134 DSGAFGQVTYTIAQVTNGGEDKFRYETATNMLVATGNLVPGERYQVVIEAID-----GGGRSSQA 193

  Fly   621 VITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDLLH-TYSEGVP 684
            ::.:                                              :..|.:| |:|...|
 Worm   194 IVIV----------------------------------------------LALDPMHQTFSSLAP 212

  Fly   685 FAIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVL 749
            .     .|:.|.:                                 .:||....:|      |.:
 Worm   213 L-----PGMETFM---------------------------------PNPLAMATTP------GTM 233

  Fly   750 ITNLTIHIVNKPEQKVPLRPVIEEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREM 814
            :|:        .|.:..::..:.|:|.|                                     
 Worm   234 VTS--------AESEETIQTFVTEVNEN------------------------------------- 253

  Fly   815 PSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRY--IIANQQEVVNKISITEDGT 877
             :.|.:..:::|.                       :::.:|.|  ::...:|  .|.:|.:.||
 Worm   254 -TPPNTVVVSLGD-----------------------ESSRELTYFNVVGGNEE--GKFAIDDAGT 292

  Fly   878 LLTLTGLDREQQPSYELTVIVE--------YSTGLVSGAGIYQVNIKVDDVNDNAPKFN------ 928
            ::|...||||:...|.|.|...        |.|         .|.:.|.|||||||.|.      
 Worm   293 IVTAEELDREKTAMYSLQVETRSRNPDQHLYWT---------LVQVTVMDVNDNAPTFTDPQPIR 348

  Fly   929 ---ALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIE-----YVNG- 984
               ::..:..:..|.::|       .|.::|||...|....:::...::..|:|.     .||| 
 Worm   349 LRLSIDDIEQLTGNMIIG-------RIGVEDADADDNGRLELRIMPPHNKLFAISNDGILSVNGD 406

  Fly   985 -TSSENSTH--------HKMPSTT----------GAFNIFNLTDQWNDEFKY-----QELHTT-- 1023
             |::....|        |..||..          |...........|:.|:|     :|..||  
 Worm   407 FTAAHFGEHDLTVVARDHGEPSLETRARVQISIFGTLITMATVAPTNEVFEYTSSVEEEPQTTNP 471

  Fly  1024 --FMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNAPM 1086
              .:||   :::.|..:         ::..||:::  ...|.....:|        |.|....|.
 Worm   472 DEHLQT---VTTSPSTK---------NQVSQQIFS--SFPAPQVEQTG--------APVEPEFPQ 514

  Fly  1087 FERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVG 1151
            |..............|...|.|:......:..|.|..|.|     |.|    |..:..:...|..
 Worm   515 FPTFPTLSPHPQIDEETEEDEEVTDEYPDTVATVPTVTVA-----PDY----SEEYGQEASSSSS 570

  Fly  1152 AGLGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVL-----------QLSASDEDFGKNALL 1205
            ..|..|....|.   :..|.::.|:  .|.::|:.....           :::.......:|.|.
 Worm   571 TILPDVQGVWSE---ISELPSENPI--TYTESPITESTAPAPETSPETAPEITPERGSSAENELY 630

  Fly  1206 HYELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTD-IDGLKDSTC 1269
            ..|:..|.||:..                    ||:.:  ||...|...|..:.| ::..::...
 Worm   631 PTEIAPENVEKPT--------------------ELAPD--LSETTENTENQWLPDVVETSQELPS 673

  Fly  1270 LRFTVM--------------DVNNHAPTFKKSWYSFDTPEGEYKDSVL-GQLTAIDMDFGENANI 1319
            |..|.|              .....||.||.|..:....|.|.:..:. ...|..|   |.:..|
 Worm   674 LPTTKMAPPQPVPTQSPPLPTPKRLAPVFKPSQITVQIDENESQVEITKAHATYPD---GLSGTI 735

  Fly  1320 TYTL--SDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVIATDNAPVMQ---RMSSSVDVEVNV 1379
            ||.|  .|..| |::...||.:.:...||.|.....:.| |:|..|..::   :::..|.:.:||
 Worm   736 TYVLHKGDPSL-FSVSSYSGSVNLLRALDAETNSTVTIQ-ISTSEAQTLEVDPKLAHFVSITINV 798

  Fly  1380 LDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGN 1444
            .|.||..|.|     ::.:.:|  .|.:.||              |||.|.|:.|.|:|.....|
 Worm   799 ADKNDWIPNF-----ESASYEF--DVKEDTL--------------PGTIVGQVNAFDQDRDEPNN 842

  Fly  1445 GLVLYSIRHQEMQA----PLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIV 1505
                 .||::.:.|    ..|.:::..|.|:....|:.:.. |.:.:.:..:|.|...||:|..|
 Worm   843 -----RIRYRLLSAGGLEAHFNVNAESGLITLARPIDAFAG-EKITLRIEGADSGMLPLSSTTTV 901

  Fly  1506 IVNLQGQAVTDPPKSTPKPEPPANVTV-FQHAYYEVKLTENNEAP--IEVMRL------------ 1555
            ::|:...:....|.::|....|....: |....|...::|....|  ::|:.:            
 Worm   902 LINVVATSSHLIPDASPVSNTPNEGELQFSLRNYTASVSEAVRPPHLVQVLSVMNKPTDTRFIIC 966

  Fly  1556 NLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSRE 1620
            |:.:|    |||.:..:..|.|            .|..|......|||.:.||.|.|..  .:..
 Worm   967 NIISG----NYRGAFGITAGND------------GNCELRTQMELDRETVERYLLNITV--TAGA 1013

  Fly  1621 ARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAPKF-----RGNGQPIVAVLPQSASFGYP 1680
            ..:||.||                   :.:.|.|||.|:|     .|......||...:.:|...
 Worm  1014 QTDYALVS-------------------ITVLDVNDNVPRFVYDSDLGLTTYFGAVSSVANAFTRV 1059

  Fly  1681 VTRVEANDLDEGLNAEIRYRL--LNEPARLFGID---ELSGNIRLLGELSRTE-HIYGFDVKATD 1739
            :| |:|.|.|.|.::.:.|.|  |:..::.|.|.   |:|....:...|||.. ..:.|.|.|.|
 Worm  1060 LT-VKAEDADLGNSSLVNYALDPLSAHSKYFSISPFGEISTKQSMSTILSRNRLQFFEFRVSACD 1123

  Fly  1740 RMGADDGRSGIVNVFVYIINEAKQVRLVVAGM-PVEVERRIEGLMEALSDAIGKDVRV---RLLE 1800
            ...:........:|.|.:|....:.::::.|: |.::::..:.|:::.....|....:   :::|
 Worm  1124 SPISGQQLCSKADVVVNVIGSTNRFKMIIYGLNPQQLKKHEKDLVKSTRQFTGSCNLLTIEKMIE 1188

  Fly  1801 PYSGGLEPATNAYIYAVDPHTNSIMEMEQLQDAL--AGLQLDALQLQQQKLDGGKPMPRILELAE 1863
            ..:...:..|:.|.|||:|.|..|.:.:.::...  :.:||.|.::|        |..|:..::|
 Worm  1189 HTAIENQIRTDIYWYAVNPTTKKICKKQDIRKLFETSNVQLIAGKVQ--------PWFRLERISE 1245

  Fly  1864 FGQLARPAHASASSFMGGL--------EFVTVVLLALISLGALIAACCYVCMRQKRRLWSQRDFS 1920
                  .|....:...||:        ..:.::|...::|||:|..|. ||:     .||:    
 Worm  1246 ------DAGDEGNMSSGGILSTNWKTSNILLIILAVTVALGAIIGICA-VCV-----FWSR---- 1294

  Fly  1921 ASDAGLTYTIAGIGSPRGQKQRRQRQQRHTQRCSKGSTGSQRPTSAFMPESVCSSAQTQSTATAT 1985
                   |..|         ||......|:.        .|:....:.|..:....:|:      
 Worm  1295 -------YKTA---------QRNASNFSHSY--------PQKLGPIYHPTMMGVDPRTE------ 1329

  Fly  1986 EKLEQQLHHHHQQQAMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVTSGGDGAVGVGST 2050
                    :.::.|.:      :..::::....|...|.||..:.:....|  .||.|..|.|. 
 Worm  1330 --------YDYETQNV------NMLISDEDLTMKSGSIGVPAHQRMTLMGA--GGGPGMGGPGG- 1377

  Fly  2051 PFVLKYNACQPVNNLNN--YETSLF-SLHSTGQDSGVEFLSSRELYETSPDSFQHGGSKRGNNTE 2112
                      |.|...|  |.|..: ..|||..:.  :|.....:|..:|.......:||.....
 Worm  1378 ----------PQNGQGNQSYRTYGYRPAHSTAYEG--DFSIEESMYAINPSGRLDPITKRIQTIV 1430

  Fly  2113 VLCP-RHAKAHLELRQPNTDSS 2133
            :..| .|.:.|     ||...|
 Worm  1431 IPTPDYHQRTH-----PNQHKS 1447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637
Cadherin_repeat 325..407 CDD:206637
Cadherin_repeat 416..524 CDD:206637 28/96 (29%)
Cadherin_repeat 534..626 CDD:206637 24/92 (26%)
Cadherin_repeat 641..>714 CDD:206637 7/73 (10%)
CA 851..925 CDD:214520 24/83 (29%)
CA 1026..1085 CDD:214520 9/58 (16%)
Cadherin_repeat 1177..1280 CDD:206637 18/128 (14%)
Cadherin_repeat 1289..1385 CDD:206637 26/101 (26%)
Cadherin_repeat 1414..1510 CDD:206637 24/99 (24%)
CA 1576..1658 CDD:214520 18/81 (22%)
Cadherin_repeat 1666..1760 CDD:206637 26/99 (26%)
cdh-5NP_001343640.1 Cadherin_repeat 4..103 CDD:206637 28/96 (29%)
Cadherin_repeat 125..201 CDD:206637 23/127 (18%)
Cadherin_repeat 245..337 CDD:206637 27/163 (17%)
Cadherin_repeat 364..439 CDD:206637 16/81 (20%)
Atrophin-1 461..>753 CDD:460830 65/353 (18%)
Cadherin_repeat 706..803 CDD:206637 25/101 (25%)
Cadherin_repeat 812..906 CDD:206637 28/115 (24%)
Cadherin_repeat 935..1030 CDD:206637 26/131 (20%)
Cadherin_repeat 1044..1142 CDD:206637 25/98 (26%)
Blue background indicates that the domain is not in the aligned region.

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