DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad89D and cdh-3

DIOPT Version :10

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:NP_498687.2 Gene:cdh-3 / 176085 WormBaseID:WBGene00000395 Length:3361 Species:Caenorhabditis elegans


Alignment Length:2507 Identity:492/2507 - (19%)
Similarity:834/2507 - (33%) Gaps:900/2507 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DSEAYPMKSSVKISQKKKASQDMAVICVWVMPLAVFGLIAIGQAAKTGQVQASSGSCAFHTLDGV 66
            :|..|.:|.:||   |.|.|..::|            .:..|:..|:.:::              
 Worm  1244 NSNFYDLKGTVK---KGKLSAPISV------------TLFFGEKMKSREIR-------------- 1279

  Fly    67 AAESEGVRFIRLREDAQVGKEILRLQAYPRSTAALKGADASGDHKYFNLTEHNATTLV--VSLAR 129
                |......:.|::.:|..:              |...:.|...:.|.:.....|:  ..:.|
 Worm  1280 ----ENELMFEIEENSPIGTVV--------------GVVPNSDTTKYRLVDPTCGLLIDQEGIIR 1326

  Fly   130 SLERLVDRDVPRNLLKFRILCAGKQEKLEEGSYLSITVYIEDVNDNAPEFLNVP----------- 183
            : ..:.||: ..:|||.:::      :..|....::.::|.|||||.|:.||.|           
 Worm  1327 T-TTVFDRE-NTSLLKTKMI------EPSENRIWNLLIFIADVNDNKPKILNAPGRIIVYDDLNY 1383

  Fly   184 ----------------YVVDVD-------ENT---SIESIIFEGVQAFDRDKPNTPNSEVHFSMS 222
                            .:||.|       |::   |:.||..|...|..|...|.|..:|||...
 Worm  1384 KLEWEDLDAIASDVSFSIVDGDVFGNLEIEDSGVISLNSIPNESFNATIRIYDNRPPFKVHFDDV 1448

  Fly   223 TVPEQ------------------------------------------------------------ 227
            |:..|                                                            
 Worm  1449 TIEFQVTQKLRAVTCEDAEFWMFFGNEDVGMLIASEIVTWRIVPQIGSDSFKIDPITGIIQSTPN 1513

  Fly   228 --------------LSADG---------------------------------------------- 232
                          :|.||                                              
 Worm  1514 TKPTSDIAKLKIQAISYDGERVGFCDVKIHIDKAAFVENVVLSNGTFEFNISETADRFTEVGKIV 1578

  Fly   233 ---------------SPYFALKSPHRPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQANTTIT 282
                           :.|....||....:.....|||:| |:.::..|       .|.::.:.:.
 Worm  1579 ILGAGLEGSVFRIQDNDYNFTISPFDGTIFTNSPLDFEN-IKTYRFNI-------TAGKSTSQVI 1635

  Fly   283 INVRDVDDLPPKFTEG-VYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQDSLNASLVYDIISGNE 346
            |:|.|.:|..|:|..| |...::.|.......|:.|....|..:    .:..|..:.|.|:||| 
 Worm  1636 IHVTDENDEAPRFITGDVVNLKVLEELDTVSYPLIIGSSIAEDL----DEGQNGLVTYSILSGN- 1695

  Fly   347 RQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEF 411
            ..||.||...|.:.....:|.||.||    ..|.:||:....|...|.::|.:.|.|:|||.|||
 Worm  1696 TSLFAVNSTTGDILSLIPLDREESSL----HELLIEAKDAGIPSLSATSKILIHVGDINDNTPEF 1756

  Fly   412 EADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRTGWITVRDDRL 476
            |...|.|.|.||...|..::::.|.|:|  :::|..|:|....:....|||:..||||||...  
 Worm  1757 ELSSYFIKISENSKIGSKIIRILATDKD--KDAELQYSLESNDEITIPFRINVATGWITVAGK-- 1817

  Fly   477 LDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLDTNDNTPKFEHGNLYEFKVPIN 541
            ::||:....:..|:..:...|            |||.|||.:.|.|||.|.....|...| ||..
 Worm  1818 VNREENEEFRFFVKVTDGEKS------------SKVIVEIHVEDFNDNHPMINDRNSDIF-VPDP 1869

  Fly   542 APTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNGTIYVGGPLRRGRIAVFVEAT 606
            ..:..:|..:..||.|:               |.::.|.|:|.|                     
 Worm  1870 TRSVEIIHVINVHDLDK---------------SDHLKFSLNNSN--------------------- 1898

  Fly   607 DQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVGQVRTTLIYEGGD-E 670
               .|.||.    ..||::                        :||.|:| .||.|:..:.|. .
 Worm  1899 ---LNLSEN----GEITLK------------------------SPLQTAV-PVRVTVSDDAGHVA 1931

  Fly   671 IMYDLLHTYS-EGVPFAIEERSGIITV-IRELSEFKRKVYQF--EAVANYLFANSSQSLVMSRSS 731
            .|..|.|.:| :..|..:|:   :.|| :||..|.:..|::.  :::...:.:..|..|.|.:|:
 Worm  1932 FMEYLFHPHSRKHFPVFVEK---LDTVSVREHDEQELAVFKANGDSIRYSIVSRCSDHLEMEKST 1993

  Fly   732 SPLTTIAS-PAELSDEGVLITNLTIHIVNKPEQKVPLRPV-IEEINMN-------VIHFHVEENV 787
            ..|.|.:| .||...|.::....|.:..|||...:....: |.:||.|       :..|:|.||.
 Worm  1994 GILKTKSSLDAEEYSECLVFIIATTYFDNKPLSTITKATIKIVDINDNSPRFDQQLYRFNVTENS 2058

  Fly   788 VGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLV-GD 851
            ...:||.::                                  :|:..|||    |:...:| ||
 Worm  2059 GPKLIGHVI----------------------------------ARDIDRSS----RVFYEIVGGD 2085

  Fly   852 ANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIK 916
            ||              ::..:||.|.:.::..||||.:..|.| ::.....|.....|...|.:.
 Worm  2086 AN--------------HEFMVTESGQIESVRDLDRETKSEYHL-IVEAIDDGKPRRRGNTTVIVT 2135

  Fly   917 VDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEY 981
            |.|.:||||:|:.:.:|. :.|:..:|..:....|   .||||..|..|.:...|:     .|.:
 Worm  2136 VLDEDDNAPRFSRIFHVE-VPEDVRIGEPVIQLSA---SDADEHSNHRFELDGGGE-----GIPF 2191

  Fly   982 VNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRG 1046
                        ::...||...:       ||                                .
 Worm  2192 ------------RVDENTGMVFV-------ND--------------------------------S 2205

  Fly  1047 LDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNAPMFER---ISVFKDSRLEIREY-TTDM 1107
            ||.||:|.|.:|:...| |.......|.|.|.|||||||:||:   :.:.:::..||.:: .:||
 Worm  2206 LDFEKKQSYRIKVKLTD-GAWLIETSLFVNVKDVNDNAPIFEKPEYLFISEENSAEIGQFHASDM 2269

  Fly  1108 EI-------------YF-VESSSGMTA------PQATAAMMLAPPPYHIPGSPRFN-------VD 1145
            :.             || :|.|:|:.:      ||...::.:....:   |.||..       ||
 Worm  2270 DSENNGKIRYSVTSPYFKIEPSTGVLSRFRQQLPQPLMSLKVTATDH---GVPRLQKTVLAHLVD 2331

  Fly  1146 RERSVGAGLGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSAS------DEDFGKNAL 1204
            :. |.|         |.::|.:|..|....:.....|:  |..:..|..:      |....|||.
 Worm  2332 KS-SFG---------KIKQRRIRETTKVGDVIGKKIDS--GATIFPLDVATVTRDGDVVLKKNAT 2384

  Fly  1205 LHYELQGEQV---ERTPGMPMLRVHGVKYFAIDKLSGELSVNYPL----------------SANI 1250
            ..:.|:.:.:   .:|..|...:...:..    .::.::|: |||                |.|.
 Worm  2385 QFWILENDTIYEFVKTDAMESTKNENITL----NITSDISM-YPLQVDGCFENFILVESRNSDNF 2444

  Fly  1251 EIM---------------------------------LNLTVTDIDGLKDSTCLRFTVMDVNNHAP 1282
            :::                                 :||.|.::|..::|..|.        ..|
 Worm  2445 KVLRNGSLIVFGFSGNQAHLKIQCDDGFWPKQDRKIINLVVNNLDADRNSFPLA--------RQP 2501

  Fly  1283 TFKKSW---------YSFDTPEGEYKDSVLGQLTAIDMDFGEN-ANITYTLSDSHLPFTIK-PAS 1336
            |.:||.         ..||:|.|    :::.:.....:.:.|| .|:.::....:|  .:| |..
 Worm  2502 TIRKSMSLPKTMILNIPFDSPTG----TIIWKNLENAVQYMENQKNVNFSNGSKNL--ILKTPLE 2560

  Fly  1337 GVLKI---GGQLDREL----------------KDKYSFQVIATDNAPVMQRMS----SSVDVEVN 1378
            ..::|   |...:|..                |:.|.|:.:|..::.....:.    ||.:::..
 Worm  2561 ETMQIDIFGQNFERSALTITPNRSLMACPVFQKNFYFFESVANLDSKHPTEIHNFGWSSDEIKGC 2625

  Fly  1379 VLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLP-VYKAYLDRSTQPGTFVRQ-----LTAIDK 1437
            .:||.|....|  |.:.:..:...|       :|| .|:..|...:|..:.:|.     :|.|..
 Worm  2626 QIDIFDKTHLF--YQNGSSLIFLKP-------LLPGTYQFSLQIKSQSDSKIRSACHVVVTVIPP 2681

  Fly  1438 DNVGNGN-GLVLYSIRHQEMQAPLFQI--------DSR------DGTISTISRIN---------G 1478
            .|:...| ..|:::.|:..: ..||.:        |.|      .||...||:::         |
 Worm  2682 TNLTTWNIPSVIFATRNYNI-PNLFHLPSGYSLSSDQRTFSLIGSGTGKNISKLSSGVYQVNVVG 2745

  Fly  1479 YNDYEHLNVSVIASDVG-------------SPALSATAIV------------------------- 1505
            .::.:.: |.::..||.             |..||...|.                         
 Worm  2746 KDEKKEI-VRILLDDVADDVTSKDIEYHVVSSTLSNLKIPTPIDVECFPRTEENLYEITKDCRLL 2809

  Fly  1506 ----IVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEV-------------M 1553
                ::|.....||.|..||      .|:.:...:...||..|||...:|:             :
 Worm  2810 FNSDVINTTIPVVTSPANST------WNLRIINESPETVKSLENNAVSLEIITQKSSIPRLITDL 2868

  Fly  1554 RLNLSAGLNPENYRWSLWLEEGLDETDAHPPF-----------EYDAKNMLLYALK--------- 1598
            |:..|   :.:.|....|  :..::...|..|           |.:|:..|...||         
 Worm  2869 RVTYS---DMKIYCLGTW--QTSEDIKYHITFVIVDRNGVVIEESEARQTLTSFLKKHRPGYLDF 2928

  Fly  1599 -PFDREHI---------SRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLN-------EC-- 1644
             .||::..         |..|..:..|..||..   :|.|..:.|..::.|:..       :|  
 Worm  2929 VDFDKDPCDGVTCIQKNSTCQPTLVGDSASRLV---SRSSSVIFDLPLKKLTARCFCSSGIDCYD 2990

  Fly  1645 -----------RI-LVHIADENDNAPK----FRGNGQPIVAVLPQSASFGYPVTRVEAND---LD 1690
                       :| ::...|:.|..|:    ...:.|||.. ..|.....|...|  |:|   :.
 Worm  2991 DTTNETIQKTQKINVITTCDDIDCGPRGKCFMEESSQPICR-CGQGFESMYSCER--ADDVFSMS 3052

  Fly  1691 EGLNAEIRYR-----LLN----------------------EPARLFGID--ELSGNIRLLG---E 1723
            .|.:.||..|     ||.                      |.:.||.:|  :....|.|:|   .
 Worm  3053 TGGSVEISVRNGTSHLLKCSENCDGRDIQKIEFDFRTVQLEKSELFRVDFGKQVALIELIGGSLT 3117

  Fly  1724 LSRTEHIYGFDVKATDRMGADDGRSGIVNVFVYIINEAKQVRLVVAGMPVEVERRIEGLMEALSD 1788
            .|.|: .|...::.......:|||..  .:...:..:.:::.:.|.|...||:.|:.  ::.|..
 Worm  3118 FSITD-AYARPIETRIEKRVNDGRWH--RLLFQMSEDGRRISIQVNGRGKEVKSRVP--LQMLFT 3177

  Fly  1789 AIGKDVRVRLLEPYSGGLEP--ATNAYIYAVDPHTNSIMEMEQLQDALAGLQLDALQLQQQKLDG 1851
            |    .:::|:.|.:.....  |.|.:::.: .:.|...|:.....:....|.|::|       .
 Worm  3178 A----KKIQLMTPAAFCFRRLLAQNQFVHPI-LNRNKFFEISSTGTSRNECQFDSIQ-------S 3230

  Fly  1852 GKPMPRILELAEFGQLARPAHASASSFMGGLEFVTVVLLALISLGALIAACCYVCMRQKRRLWSQ 1916
            |....|:.                |:|......:.::.||||||...     .||:...||.|.|
 Worm  3231 GSGGFRLF----------------SNFSNTTTLILLITLALISLIGF-----SVCLLAIRRRWRQ 3274

  Fly  1917 RDFSASDAGLTYTIAGIGSPRGQKQRRQRQQRHTQRCSKGSTGSQRP-TSAFMPESVCSSAQTQS 1980
            :                 ||..|||        |:| |.|.||...| ....:..|:..|....:
 Worm  3275 K-----------------SPGDQKQ--------TER-SNGWTGHVMPRRRGHINRSMVKSPDDDT 3313

  Fly  1981 TATATEKLEQQLHHHHQQQAMATQQQHHQYLNEQQRQ 2017
            ...||.         :..::.:|....|.|.:...|:
 Worm  3314 YDVATV---------YGMKSTSTDDITHIYTSSSSRR 3341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 34/278 (12%)
Cadherin_repeat 325..407 CDD:206637 25/81 (31%)
Cadherin_repeat 416..524 CDD:206637 33/107 (31%)
Cadherin_repeat 534..626 CDD:206637 17/91 (19%)
Cadherin_repeat 641..>714 CDD:206637 20/77 (26%)
CA 851..925 CDD:214520 19/73 (26%)
CA 1026..1085 CDD:214520 17/58 (29%)
Cadherin_repeat 1177..1280 CDD:206637 22/160 (14%)
Cadherin_repeat 1289..1385 CDD:206637 21/120 (18%)
Cadherin_repeat 1414..1510 CDD:206637 27/166 (16%)
CA 1576..1658 CDD:214520 22/132 (17%)
Cadherin_repeat 1666..1760 CDD:206637 26/128 (20%)
cdh-3NP_498687.2 Cadherin_repeat 31..113 CDD:206637
Cadherin_repeat 121..225 CDD:206637
Cadherin_repeat 242..326 CDD:206637
Cadherin_repeat 448..529 CDD:206637
Cadherin_repeat 637..734 CDD:206637
Cadherin_repeat 1116..1184 CDD:206637
Cadherin_repeat 1285..1364 CDD:206637 17/100 (17%)
Cadherin_repeat 1559..1643 CDD:206637 13/91 (14%)
Cadherin_repeat 1671..1752 CDD:206637 27/89 (30%)
Cadherin_repeat 1760..1853 CDD:206637 33/108 (31%)
CA 1975..2043 CDD:214520 18/67 (27%)
Cadherin_repeat 2050..2142 CDD:206637 30/144 (21%)
Cadherin_repeat 2149..2241 CDD:206637 31/152 (20%)
Cadherin_repeat 2250..2329 CDD:206637 14/81 (17%)
LamG 3082..3201 CDD:214598 24/127 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.