Protein Alignment Cad89D and Cdhr5

DIOPT Version :10

• Sequence 1: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Sequence 2: NP_612534.1
• Gene: Cdhr5 / 171554
• RGDID: 620504
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 396
• Identity: 102/396 - (25%)
• Similarity: 172/396 - (43%)
• Gaps: 80/396 - (20%)

  Fly   134 LVDRDVPRNLLKFRILCAGKQEKLEEGSYLSITVYIEDVNDNAPEFLNVPYVV---DVDENTSIE 195
            :|..|...|.|...:|...:.:.|.  :...:.|.:.|:|||||||   |:.:   :|.|:|.:.
  Rat    84 IVTPDYEENSLLEAVLECKRGDTLV--TQFRVFVAVLDINDNAPEF---PFTIKEYNVSEDTRVN 143

  Fly   196 SIIF--EGVQAFDRDKPN---------TPNSEVHFSMSTVPEQLSADGSPYFAL-------KSPH 242
            :|:.  ..::|.|.||.:         |||:...||:..:       .||...|       |||:
  Rat   144 TIVIPETELKATDADKDDILVYTLQEVTPNASKFFSLVGI-------NSPALKLDQTLDYYKSPN 201

  Fly   243 RPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQANTTITINVRDVD-----DLPPKFTEGVY-- 300
            ....:|.|:...:|.|              |::.|..|:.:||...|     .||..||:..:
  Rat   202 MTFRLLARDTREENVI--------------PSHTATATVVLNVLPADLRTPWFLPCSFTDDYFCI 252

  Fly   301 RTRINEFYPMTGVPIRIPLYFAP-PIMAFDQD-SLNASLVYDIISGNERQLFRVNPHNGVMYLQK 363
            :.:.:...| ||..:..||..:| ||.|.|.| ::|..:||.|:.||....|.:|..:|.:.:.|
  Rat   253 QAQYHTVIP-TGHKLPSPLILSPGPIYAVDGDQAINQPIVYSIMMGNTDDTFIINKDDGNLTMAK 316

  Fly   364 EIDLEEESLPG-NTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNISIVENLPTG 427
                   |:|. .||.|.:.|.|.| ..:.::.:..||..|:..|..:|....|..::|.....|
  Rat   317 -------SIPSPMTFTLVVRAEQAD-MARYSVTQAVVEARDVTGNPLQFSQSLYFGTVVLGSEAG 373

  Fly   428 FSVLQVNAVDRDQGENSEFL-----YNLVETKDAAGAFRIDSRTGWITVRDDRL--LDREQRRSI 485
            .:|       :|:...||.|     |......::|..:::.:.:.:|..:|..|  :..|..|:|
  Rat   374 TAV-------KDKTFPSEILRIQAQYLGFPDLNSAVTYQVTNSSEFIMNKDILLTTVPMETERTI 431

  Fly   486 QLNVEA 491
            ::.|||
  Rat   432 RIEVEA 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	30/132 (23%)
		Cadherin_repeat	325..407	CDD:206637	25/83 (30%)
		Cadherin_repeat	416..524	CDD:206637	19/83 (23%)
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520
		CA	1026..1085	CDD:214520
		Cadherin_repeat	1177..1280	CDD:206637
		Cadherin_repeat	1289..1385	CDD:206637
		Cadherin_repeat	1414..1510	CDD:206637
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
Cdhr5	NP_612534.1	Cadherin_repeat	133..231	CDD:206637	27/118 (23%)
		Cadherin_repeat	255..353	CDD:206637	32/106 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..658
		Herpes_BLLF1	<470..>650	CDD:282904
		4 X 31 AA approximate tandem repeats	545..648
		Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9HBB8	693..862
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..803
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..862