DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and Cdhr1

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	NP_570948.1	Gene:	Cdhr1 / 170677	MGIID:	2157782	Length:	859	Species:	Mus musculus

Alignment Length:	773	Identity:	188/773 - (24%)
Similarity:	304/773 - (39%)	Gaps:	181/773 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VFGLIAIGQAAKTGQVQASSGSCAFHTLD-GVAAESEGVRFIRLREDAQVGKEILRLQAYPRSTA 99
            |.||:         ::..:..:.|.|..| ||.:.:..:....|.||..||..:.
Mouse    10 VLGLL---------RIYLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVY---------- 55

  Fly   100 ALKGADASGDHKYFNLTEHNATTLVVSLARSLERL-----VDRDVPRNLLKFRILCAGKQEKLE- 158
            .|.|.|..||...::::...:|..|.|:..:...:     :||:              :::::|
Mouse    56 TLNGTDPEGDPISYHISFDPSTRSVFSVDPNFGNITLVEELDRE--------------REDEIEA 106

  Fly   159 -----EGSYL---SITVYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNS 215
                 :|..|   .:.:.:.|.||.||.|:..||::.|.||....|.||: |||.|:|
Mouse   107 IISISDGLNLVAEKVVILVTDANDEAPRFIQEPYIIRVPENIPAGSSIFK-VQAEDKD------- 163

  Fly   216 EVHFSMSTVPEQLSADGSPYFALKSPHRPLLILKRE-----------LDFDNGIRQFKLPIFAWD 269
                        ..:.||..::|::.|.....:.|.           ||::.. |...:.:.|.|
Mouse   164 ------------TGSGGSVTYSLQNLHSSKFSMDRHSGVLRLQAGATLDYEKS-RAHYITVIAKD 215

  Fly   270 RGTPAN------QANTTITINVRDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAF 328
            .|....      .|.||:||||.||.|..|.|....|...:.|        ..:|......::|.
Mouse   216 GGGRLRGADMVFSATTTVTINVEDVQDTAPIFVGTPYYGYVYE--------DTLPGSEVLTVVAI 272

  Fly   329 DQDSLNAS-LVYDIISGNERQLFRVNPHNG-VMYLQKEIDLEEESLPGNTFVLQL-----EARQK 386
            |.|....: ::|.:::.:: .:|.:|..:| :..||....|..|       |.:|     |....
Mouse   273 DGDRGKPNHILYRLLNESD-GIFEINETSGAISVLQSPALLRRE-------VYELHVQVTEVNSP 329

  Fly   387 DNPLKKALARIEVEVLDLNDNVPEFEAD-----YYNISIVENLPTG--FSVLQVNAVDRDQGENS 444
            .:|..:|...:.:.::|||::.|.|..:     .:.:|:.|:.|.|  ...|::...|.|||.|:
Mouse   330 GSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVNDSDQGANA 394

  Fly   445 EFLYNLVETKDAAGAFRIDSRT------GWITVRDDRLLDREQRRSIQLNVEALERN-PSYLDDK 502
            :|...||   ...|.||:..:|      ..|.|.:...:|.|:.:.:...:.|:|.| |....
Mouse   395 KFNLRLV---GPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKLLTFKLLAIEVNTPEKFS-- 454

  Fly   503 HLKKPGPSKVQVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYE 567
                   |...:.|.|||||||.|||. .:.|..::|.|||.|..:..|.|.|||.||.|.:.|.
Mouse   455 -------STADIVIQLLDTNDNVPKFT-SHYYIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYS 511

  Fly   568 LQRPKGSGYIPFRLDNKNGTIYV---------GGPLRRGRIAVFVEATDQPTNPSERRFSLAVIT 623
            :.   |:|...|.:....|.||.         |    ..|...:|:|.|.     :.|:|||
Mouse   512 IY---GTGSDLFLIHPSTGLIYTQPWASLDAEG----TSRYNFYVKAEDM-----DGRYSLA--- 561

  Fly   624 IEVYAT---IDDQAIDFVGAPYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGV-P 684
             ||:.|   ::|....||.:..|..:...|||     ::..|.........:.|...|.:|.| .
Mouse   562 -EVFVTLLDVNDHYPQFVQSVQEKTMVLGTPL-----KIEATDQDAEEPNNLVDYSITRAEPVNV 620

  Fly   685 FAIEERSGIITVIRELSEFKRKVYQFEAVANYL----FANSSQSLVMSRSSSPLTTIA 738
            |.|:..:|.|       ..|..:...||:.|..    ::.|.|.....|.|...:|.|
Mouse   621 FDIDAHTGEI-------RLKNSIRSLEALHNITPSGDYSWSLQVQAKDRGSPSFSTTA 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	33/123 (27%)
		Cadherin_repeat	325..407	CDD:206637	19/88 (22%)
		Cadherin_repeat	416..524	CDD:206637	32/116 (28%)
		Cadherin_repeat	534..626	CDD:206637	30/100 (30%)
		Cadherin_repeat	641..>714	CDD:206637	16/73 (22%)
		CA	851..925	CDD:214520
		CA	1026..1085	CDD:214520
		Cadherin_repeat	1177..1280	CDD:206637
		Cadherin_repeat	1289..1385	CDD:206637
		Cadherin_repeat	1414..1510	CDD:206637
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
Cdhr1	NP_570948.1	Cadherin_repeat	42..130	CDD:206637	19/111 (17%)
		Cadherin_repeat	139..242	CDD:206637	33/123 (27%)
		Cadherin_repeat	251..350	CDD:206637	22/114 (19%)
		Cadherin_repeat	364..469	CDD:206637	32/116 (28%)
		Cadherin_repeat	478..573	CDD:206637	33/110 (30%)
		Cadherin_repeat	580..679	CDD:206637	23/104 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910