DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad89D and Cdh23

DIOPT Version :9

Sequence 1:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster
Sequence 2:XP_038954289.1 Gene:Cdh23 / 114102 RGDID:619760 Length:3352 Species:Rattus norvegicus


Alignment Length:2806 Identity:603/2806 - (21%)
Similarity:930/2806 - (33%) Gaps:995/2806 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 HKYFNLTEHNATTLVVSLARSLERLVDRDVP--------RNLLKFRILCAGKQEKLEEGSYLSIT 166
            :|:::|   |:||   ...|:...::||:.|        |.::.....|.  :..|:..|..::.
  Rat   819 NKFYSL---NSTT---GKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCG--RPPLKATSSATVF 875

  Fly   167 VYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNSEVHFSMSTVPEQLSAD 231
            |.:.|:|||.|.|.|:|:|.:|.|.|.....::: |.|.|.|:  ..|..|.:.|..        
  Rat   876 VNLLDLNDNDPTFQNLPFVAEVLEGTPAGVSVYQ-VVAIDLDE--GLNGLVSYRMQV-------- 929

  Fly   232 GSPY--FALKSPHRPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQANTTITINVRDVDDLPPK 294
            |.|.  |.:.|. ..::....|||.:. |.:::|.:.|.|.|||...:.:|:||.|.||:|..|.
  Rat   930 GMPRMDFVINST-SGVVTTTAELDRER-IAEYQLRVVASDAGTPTKSSTSTLTIRVLDVNDETPT 992

  Fly   295 FTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQD-SLNASLVYDIISGNERQLFRVNPHNGV 358
            |...||...::|     .||....:.:   :...|.| .|||.|.|.|.:||....|.|...:.|
  Rat   993 FFPAVYNVSVSE-----DVPREFRVVW---LNCTDNDVGLNAELSYFITAGNVDGKFSVGYRDAV 1049

  Fly   359 MYLQKEIDLEEESLPGNTFVLQLEARQKDN-PLKK---ALARIEVEVLDLNDNVPEFEADYYNIS 419
              ::..:.|:.|:....|.||:    ..|| |:.|   ..|.:.|.|||:|||.|.|....|..|
  Rat  1050 --VRTVVGLDRETTAAYTLVLE----AIDNGPVGKRRTGTATVFVTVLDVNDNRPIFLQSSYEAS 1108

  Fly   420 IVENLPTGFSVLQVNAVDRDQGENSEFLYNLV--------------------------------- 451
            :.|::|.|.|::|:.|.|.|:||.....|.::                                 
  Rat  1109 VPEDIPEGHSIVQLKATDADEGEFGRVWYRILHGNHGNNFRLHVSSGLLVRGPRPLDRERNSSHV 1173

  Fly   452 -------------------------------------------------------------ETKD 455
                                                                         :|.|
  Rat  1174 LMAEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYNRLGLRETAGIGTSVIVVRATDRDTGD 1238

  Fly   456 -----------AAGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALERNPSY----------- 498
                       |.|.|.||..||.|...|  .||.|.:.|..:||.|.:..|.:           
  Rat  1239 GGLVNYRILSGAEGKFEIDESTGLIVTVD--YLDYETKTSYLMNVSATDGAPPFNQGFCSVYVTL 1301

  Fly   499 ---LDD-------------------------------------------------KHLKK----- 506
               ||:                                                 |.|.|     
  Rat  1302 LNELDEAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLNQITYRFDAYTSAQAKALFKIDAIT 1366

  Fly   507 -------------------------PGP---SKVQVEITLLDTNDNTPKFEHGNLYEFKVPINAP 543
                                     .||   |.|:|.:|:||.|||:|:|:..:.....||.:.|
  Rat  1367 GVITVKGLVDREKGDFYTLTVVADDGGPKVDSTVKVYVTVLDENDNSPRFDFTSDSAISVPEDCP 1431

  Fly   544 TGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYI--PFRLDNKN---GTIYVGGPLRRGRIAVF- 602
            .|..:..|.|.|||.|.||.:::.|    .||.|  .|.:...|   |.::|..||.|..:..: 
  Rat  1432 VGQRVATVKARDPDAGSNGQVVFSL----ASGNIAGAFEIITSNDSIGEVFVAKPLDREELDHYI 1492

  Fly   603 --VEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPL--GTSVGQVRTT- 662
              :.|:|:.|.|.::...|.|..::|.   |:..:  :.:|:.:.|..|..:  ||||.|||.| 
  Rat  1493 LKIVASDRGTPPRKKDHILQVTILDVN---DNPPV--IESPFGYNVSVNENVGGGTSVVQVRATD 1552

  Fly   663 -----------LIYEGGDEI------------------------MYDLLHTY-SEGVP------- 684
                       .|.||.:::                        .|.|:.|. .||.|       
  Rat  1553 RDIGINSVLSYYITEGNEDMTFRMDRISGEIATRPAPPDRERQNFYHLVVTVEDEGTPTLSATTH 1617

  Fly   685 ---------------------------------------------------------------FA 686
                                                                           |.
  Rat  1618 VYVTIVDENDNAPVFQQPHYEVVLDEGPDTVNTSLITVQALDLDEGPNGTVTYAIVAGNIINTFR 1682

  Fly   687 IEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQSLVMSRSSS-PLTTIASPAELSDEGVLI 750
            |..|:|:||..:||              :|..::...:|:::.:.. |:        ||..   :
  Rat  1683 INRRTGVITAAKEL--------------DYEISHGRYTLIVTATDQCPI--------LSHR---L 1722

  Fly   751 TNLTIHIVNKPEQKVPLRPVIEEINMNVIHF---------------------------------H 782
            |:.|..:||           :.:||.||..|                                 .
  Rat  1723 TSTTTVLVN-----------VNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTFLAHDRDSGPNGQ 1776

  Fly   783 VEENVVGG----------IIGQLLYKNGINLVNNELGTY------REMPSEPTSRNITMGSRFRS 831
            ||.:||.|          :.|.|..:..:.|....:..|      |:....|.|..:.:|.|...
  Rat  1777 VEYSVVDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGVPPLSSTMLVGIRVLD 1841

  Fly   832 RNR--------------SRSSKSKRRLPRRLVGDA----NIKLRY-IIANQQEVVNKISITEDGT 877
            .|.              |.:|.....:...|..||    |..|.: |.|..:|....|:.| .|.
  Rat  1842 INDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNALLTFNITAGNRERAFFINAT-TGI 1905

  Fly   878 LLTLTGLDREQQPSYELTVIV------------EYSTGLVSGAGIYQVNIKVDDVNDNAPKFNAL 930
            :.....||||:.|.|.|||.|            ::...|||.|          |.|||.|.|...
  Rat  1906 VTVNRPLDRERIPEYRLTVSVKDNPENPRIARKDFDLLLVSLA----------DENDNHPLFTEG 1960

  Fly   931 TYVGLINENCVVGTELS-MNHAILIQDADEGPNAEFRVQLQGDYSDEFSIE-------------- 980
            ||...:.||...||.|: :|..||..||||...|....||.|.:||.|.|:              
  Rat  1961 TYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGTHSDLFVIDNSTGVVTVRSGVII 2025

  Fly   981 --------------------YVNGTS-------SENS----------THHKMPSTTGAFNIFNLT 1008
                                .:|||:       .:|.          |.|.:.:....|::..:|
  Rat  2026 DREAFSPPFLELLLLAEDVGQLNGTAYLFITILDDNDNWPTFSPPAYTVHLLENCPPGFSVLQIT 2090

  Fly  1009 DQWNDEFKYQELHTTFMQTNFKLSSG--------PYFRISYTGKRGLDREKQQLYNLKIIAADTG 1065
            ....|.....||       .:::.:|        |...:...|...:|||:|:.|.|.::|.|.|
  Rat  2091 ATDEDSGLNGEL-------VYRIEAGAQDRFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRG 2148

  Fly  1066 --GLSGYAHLTVLVADVNDNAPMF----ERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQAT 1124
              .|||.|.:|:|:.|:||:.|.|    :.:||.:                  .:..|......|
  Rat  2149 TVPLSGTATVTILIDDINDSRPEFLNPIQTVSVLE------------------STEPGTVIANVT 2195

  Fly  1125 AAMMLAPP--PYHI------PGSPRFNVDRERSVGAGL---GVVARAKSRRRMVRA--------- 1169
            |..:...|  .|||      ..:.|...|:|.:....:   .|:.::...|.:|..         
  Rat  2196 AIDLDLNPKLEYHILSIVAKDDTDRLVPDQEDAFAVNINTGSVIVKSPLNRELVATYEVTLSVID 2260

  Fly  1170 -----------------------LTTKCPLF----------AIYEDTPVGTKVLQLSASDEDFGK 1201
                                   :....|.|          .:.|....||.::.::|.|.|.|.
  Rat  2261 NASDLPERSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERVLEGATPGTTLIAVAAVDPDKGL 2325

  Fly  1202 NALLHYELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKD 1266
            |.|:.|.|. :.:  .||...|.         |..:|::..|..:.......||.||...|....
  Rat  2326 NGLITYTLL-DLI--PPGYVQLE---------DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP 2378

  Fly  1267 STCLRFTV----MDVNNHAPTFKKSWYSFDTPEGEYKDSVLG----QLTAIDMDFGENANITYTL 1323
            .......|    :|:|::.|.|.:..|.    |..::|..:|    ::||.|.|.|..|.|.|:|
  Rat  2379 PRAAEIPVYLEIVDINDNNPIFDQLSYQ----EAVFEDVAVGTVILRVTATDADSGNFALIEYSL 2439

  Fly  1324 SDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVIATDNA--PVMQRMSSSVDVEVNVLDINDNR 1386
            .|....|.|.|.:|.:.:...||||.||.|....:|.||.  ....|..:||.|.:.|||:||.|
  Rat  2440 VDGEGKFAINPNTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIRVLDVNDCR 2504

  Fly  1387 PEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSI 1451
            |:|                     ..|.:...:..:...||.|..:.|.|:|.  ..||.:.||:
  Rat  2505 PQF---------------------SKPQFSTSVYENEPAGTSVITMLATDQDE--GSNGQLTYSL 2546

  Fly  1452 RHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQGQAVTD 1516
            ....|:|  |.:|...|.::|...:   ..||..|::|:|:|.|.|.|..|.:::|.     |.|
  Rat  2547 EGPGMEA--FSVDMDSGLVTTQRPL---QSYERFNLTVVATDGGEPPLWGTTMLLVE-----VID 2601

  Fly  1517 PPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEGLDETDA 1581
            ...:.|....|.|.|:. |...|:.|..|   ..||...:...|||.. .|:|.....|..:.:.
  Rat  2602 VNDNRPVFVRPPNGTIL-HIKEEIPLRSN---VYEVYATDKDEGLNGA-VRYSFLKSTGNRDWEY 2661

  Fly  1582 HPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRI 1646
               |..|..:.|:...:..|||..:.|.|.:.|..|.:          ||..|.::.|.      
  Rat  2662 ---FTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQ----------PVPYETMQPLQ------ 2707

  Fly  1647 LVHIADENDNAPKF----RGNGQPIVAVLPQSASFGYPVTRVE-ANDLDEGLNAEIRYRLL--NE 1704
             |.:.|.:||.|.|    :|:.|..:..:|:.:..|..|..|. |.|.|||.||.:.|.:.  ||
  Rat  2708 -VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNE 2771

  Fly  1705 PARLFGIDELSGNIRLLGELSR-TEHIYGFDVKATDR---------------------------- 1740
            . :.|.: :..|.:.:|.:|.| ||.|:.|.|||:..                            
  Rat  2772 D-KNFHL-QPDGRLLVLRDLDRETEAIFSFIVKASSNRSWTPPRGPSPALDLLTDLTLQEVRVVL 2834

  Fly  1741 ----------------------------------MGADDGRS----------------------- 1748
                                              :.||.|.:                       
  Rat  2835 EDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILAIHYFRALANDSEDV 2899

  Fly  1749 ----------GIVNVF------------------------------VYIINEAKQVRLVVAGMPV 1773
                      ||:..|                              :||:.:.::|::|:..:|.
  Rat  2900 GQVFTMGSVDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIPD 2964

  Fly  1774 EVERRIEGLMEALSDAIGKDVR---VRLLEPYSGGLEPA-TNAYIYAVDPHTNSIMEMEQLQDAL 1834
            .|....|..:..||:..|..|.   |:......|.:..| |...|:.|:..||.|::::::    
  Rat  2965 RVRGFEEEFIRLLSNITGAIVNTDDVQFHVDMKGRVNFAQTELLIHVVNRDTNRILDVDRV---- 3025

  Fly  1835 AGLQLDALQLQQQKLDGGKPMPRILELAEFGQL-ARPA-HASASSFMGGLEFVTVVLLALISLGA 1897
                       .|.:|..|...|.| ...:..| .:|| .......|..|:...:||..|:.|.|
  Rat  3026 -----------IQMIDENKEQLRNL-FRNYNVLDVQPAISVQLPDDMSALQMAIIVLAILLFLAA 3078

  Fly  1898 LIAACCYVCMRQKRRLWSQRDFSASDAGLTYTIAGIGSPRGQKQRRQRQQRHTQR---------- 1952
            ::    :|.|....|...:|...|       .:||....||..........:...          
  Rat  3079 ML----FVLMNWYYRTIHKRKLKA-------IVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLD 3132

  Fly  1953 --CSKGSTGSQRPTSAFMPESVCSSAQTQSTATATEKLEQQLHHHHQQQAMATQQQHHQYLNEQQ 2015
              |......:|......:||::...|...::.|.|       |....::..|.:.:..:||    
  Rat  3133 PFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRT-------HGTFGREPAAVKPEDDRYL---- 3186

  Fly  2016 RQQKREYIDVPLPKSIAKAAAVTSGGDGAVGVGSTPFVL-------KYNACQPVNNLNNYETSLF 2073
            |...:||      .:|||...:..  :|.:.......||       |..|.:.|...::..:|:.
  Rat  3187 RAAIQEY------DNIAKLGQIIR--EGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSCHSSIS 3243

  Fly  2074 SLHSTGQDSGVEFLSSRELYETSPDSFQHGGSKRGNNTEVLCPRHAKAHLELRQPN--------- 2129
            .|..|            :|.|...|.....||.|.        || |...||:.|:         
  Rat  3244 ELIHT------------DLEEEPGDHSPGQGSLRF--------RH-KPPTELKGPDGIHIVHGST 3287

  Fly  2130 -----TDSSDTYEDSLK-TDEPLVAHNCRSANCEHRQHQQHPSHHPHYQNTRFEK-RSCVRHSFS 2187
                 ||.:...||..| .|..|.......|....|             |.|.|. :|...|...
  Rat  3288 GTLLATDLNSLPEDDQKGLDRSLETLTASEATAFER-------------NARTESAKSTPLHKLR 3339

  Fly  2188 GVKDDLMQQSP 2198
                |::.:||
  Rat  3340 ----DVIMESP 3346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 32/108 (30%)
Cadherin_repeat 325..407 CDD:206637 28/86 (33%)
Cadherin_repeat 416..524 CDD:206637 46/308 (15%)
Cadherin_repeat 534..626 CDD:206637 29/99 (29%)
Cadherin_repeat 641..>714 CDD:206637 28/181 (15%)
CA 851..925 CDD:214520 28/90 (31%)
CA 1026..1085 CDD:214520 21/68 (31%)
Cadherin_repeat 1177..1280 CDD:206637 26/116 (22%)
Cadherin_repeat 1289..1385 CDD:206637 36/101 (36%)
Cadherin_repeat 1414..1510 CDD:206637 27/95 (28%)
CA 1576..1658 CDD:214520 18/81 (22%)
Cadherin_repeat 1666..1760 CDD:206637 34/222 (15%)
Cdh23XP_038954289.1 Cadherin_repeat 42..128 CDD:206637
Cadherin_repeat 136..231 CDD:206637
Cadherin_repeat 240..344 CDD:206637
Cadherin_repeat 352..454 CDD:206637
Cadherin_repeat 463..555 CDD:206637
Cadherin_repeat 564..665 CDD:206637
Cadherin_repeat 674..772 CDD:206637
Cadherin_repeat 780..884 CDD:206637 16/72 (22%)
Cadherin_repeat 892..988 CDD:206637 32/108 (30%)
Cadherin_repeat 997..1096 CDD:206637 33/112 (29%)
Cadherin_repeat 1104..1201 CDD:206637 13/96 (14%)
Cadherin_repeat 1216..1306 CDD:206637 19/91 (21%)
Cadherin_repeat 1315..1412 CDD:206637 12/96 (13%)
Cadherin_repeat 1424..1521 CDD:206637 30/103 (29%)
Cadherin_repeat 1531..1628 CDD:206637 19/96 (20%)
Cadherin_repeat 1636..1738 CDD:206637 19/137 (14%)
Cadherin_repeat 1750..1845 CDD:206637 15/94 (16%)
Cadherin_repeat 1853..1953 CDD:206637 29/110 (26%)
Cadherin_repeat 1961..2063 CDD:206637 26/101 (26%)
Cadherin_repeat 2072..2167 CDD:206637 26/101 (26%)
Cadherin_repeat 2178..2287 CDD:206637 15/126 (12%)
Cadherin_repeat 2299..2396 CDD:206637 25/108 (23%)
Cadherin_repeat 2404..2502 CDD:206637 35/101 (35%)
Cadherin_repeat 2511..2605 CDD:206637 29/105 (28%)
Cadherin_repeat 2618..2716 CDD:206637 28/122 (23%)
Cadherin_repeat 2733..2839 CDD:206637 26/107 (24%)
Cadherin_repeat 2848..2949 CDD:206637 7/100 (7%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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