DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad89D and cdh9

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	XP_017950449.1	Gene:	cdh9 / 100495910	XenbaseID:	XB-GENE-6039319	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	905	Identity:	176/905 - (19%)
Similarity:	307/905 - (33%)	Gaps:	342/905 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   850 GDANIKLRYIIANQQEVVNKISITED--GTLLTLTGLDREQQPSYEL-TVIVEYSTGLVSGAGIY 911
            |:.|:|  ||::.  :....:.|.::  |.:.....||||::..|.| .:.::..||       .
Frog    87 GEGNLK--YILSG--DGAGSVFIIDENTGDIQAAKRLDREEKSMYVLRAMAIDRKTG-------K 140

  Fly   912 QVN------IKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQ 970
            ||.      ||:.|:|||.|||....|...:.|...|||.:....|:...|...|.:|:.
Frog   141 QVEPESQFVIKIHDINDNEPKFTKDVYYASVPEMSEVGTSVIQVTALDNDDPSYGNSAKI----- 200

  Fly   971 GDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGP 1035
                                             ::::                       :...|
Frog   201 ---------------------------------VYSI-----------------------IQGQP 209

  Fly  1036 YFRIS------YTGKRGLDREKQQLYNLKIIAAD----TGGLSGYAHLTVLVADVNDNAPMFERI 1090
            ||.|.      .|....::||.::.|.:.|.|.|    .|||||...:.:.:.|||||.|.|.:
Frog   210 YFSIDPESGIIKTALPDMNRENREHYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQ- 273

  Fly  1091 SVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLG 1155
            |:::
Frog   274 SIYQ------------------------------------------------------------- 277

  Fly  1156 VVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYE-LQGEQ------ 1213
                                 |:..|...:|..:.::.|:|||.||||.:||: :.|::
Frog   278 ---------------------FSSTESAAIGKAIGRIKANDEDMGKNAEIHYKIIDGDEEGHFDI 321

  Fly  1214 ------------VERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVT----DID 1262
                        |::.......|:|                .:.:.|:     |:.|.    .:.
Frog   322 ITDQETQEGIITVKKLLDFESRRLH----------------TFEVEAS-----NMNVEPRFFHLG 365

  Fly  1263 GLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTL---S 1324
            ..||:..::..:.|. :.||.|.||:|..:..|...:.:::||:||.|.|..:|. :.|::   :
Frog   366 PFKDTATVKVVLQDA-DEAPVFSKSFYVIEVDEDAKEGNIVGQVTAQDPDSSKNP-VRYSIDRNT 428

  Fly  1325 DSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVIATD-NAPVMQRMSSSVDVEVNVLDINDNRPE 1388
            |....|:|...:|.:.:...||||....::..||||: |.|   ::|.||.|...:|||||:.||
Frog   429 DIEKMFSIYSGNGSIFLEKSLDREEIPWHNITVIATEANNP---KLSRSVHVYFKILDINDHAPE 490

  Fly  1389 FIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRH 1453
            |..:                      |:.::..:.:.|..::.::|||||....|:......:..
Frog   491 FAKH----------------------YETFVCENAKQGQLIQTVSAIDKDEPPRGHRFYFEMVPD 533

  Fly  1454 QEMQAPLFQIDSRDGTISTISRINGY----------------NDY------EHLNVSVIASD--- 1493
            ..:......:|::|.|.|..::.|||                |||      |.|.:.|.|.|
Frog   534 FSINPNFTVLDNKDNTASIFTKRNGYNRHKISTYVLPIIIFDNDYPVQSSTETLTIRVCACDSKG 598

  Fly  1494 ---------------VGSPALSATAIVIVNLQG-----QAVTDPPKSTP----KPEPPANVTVFQ 1534
                           :.:.||.|..:.|:.|..     .|:....|..|    |.:...||..:.
Frog   599 NMQSCNLEATFFPAGLSTGALIAILLCIIILLTLVILFTALKRQRKKEPLIFSKDDVRDNVVTYN 663

  Fly  1535 H--------AYYEVKLTENNEA-----------PIEVMRLNLSAGLNPENYRWSLWLEEGLDETD 1580
            .        ..:::....|.||           |..|.::.....| .||.....::.:.|:|.|
Frog   664 DEGGGEEDTQAFDISTLRNPEARDENKLRRDILPDTVFQIRKPVPL-WENIDVQDFIHKRLNEND 727

  Fly  1581 AH---PPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIE 1637
            ..   ||::    ::..||.:..|                 ..|...:.:..|.::|.::
Frog   728 TDTTAPPYD----SLATYAYEGND-----------------SIAETLSSLESPAIEENLD 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520	22/82 (27%)
		CA	1026..1085	CDD:214520	21/68 (31%)
		Cadherin_repeat	1177..1280	CDD:206637	23/125 (18%)
		Cadherin_repeat	1289..1385	CDD:206637	32/99 (32%)
		Cadherin_repeat	1414..1510	CDD:206637	27/135 (20%)
		CA	1576..1658	CDD:214520	11/65 (17%)
		Cadherin_repeat	1666..1760	CDD:206637
cdh9	XP_017950449.1	CA	82..160	CDD:214520	23/83 (28%)
		Cadherin_repeat	166..267	CDD:206637	28/161 (17%)
		Cadherin_repeat	275..382	CDD:206637	23/210 (11%)
		Cadherin_repeat	391..487	CDD:206637	32/99 (32%)
		Cadherin_repeat	494..592	CDD:206637	20/119 (17%)
		Cadherin_C	640..790	CDD:366437	24/149 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11590
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000