DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad89D and cdh8

DIOPT Version :9

Sequence 1:	NP_650554.3	Gene:	Cad89D / 42006	FlyBaseID:	FBgn0038439	Length:	2240	Species:	Drosophila melanogaster
Sequence 2:	XP_002935098.2	Gene:	cdh8 / 100486228	XenbaseID:	XB-GENE-1002704	Length:	810	Species:	Xenopus tropicalis

Alignment Length:	752	Identity:	183/752 - (24%)
Similarity:	284/752 - (37%)	Gaps:	244/752 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   816 SEPTSRNITMGSRFRSRNRSRSSKSKRR------------------LPRRLVGD---ANIKLRYI 859
            |...|.|.||.....|..:...::|||.                  |..||..|   .|.|::||
Frog    46 SHTLSTNGTMELNGVSEEQKLLNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGNTKIKYI 110

  Fly   860 IANQQEVVNKISITED--GTLLTLTGLDREQQPSYELTV-IVEYSTG--LVSGAGIYQVNIKVDD 919
            ::.  |....|.:..|  |.:..:..||||::..|.||. .|:..|.  |...:   :..|||.|
Frog   111 LSG--EGAGTIFVINDKTGDIHAMKRLDREEKAEYTLTAQAVDRDTNKPLEPPS---EFIIKVQD 170

  Fly   920 VNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADE---GPNAEFRVQ-LQGDYSDEFSIE 980
            :|||||:|....|...:.|..:|||.::   .:...|||:   |.:|:.... |:|  ...||||
Frog   171 INDNAPEFLNGPYHATVPEMSIVGTYVT---KLTATDADDPVYGNSAKLVYSILEG--QPYFSIE 230

  Fly   981 YVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKR 1045
                                                                  |:..|..|...
Frog   231 ------------------------------------------------------PHTAIIKTALS 241

  Fly  1046 GLDREKQQLYNLKIIAAD----TGGLSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTD 1106
            .:|||.::.|.:.|.|.|    .|||||...:||.:.|||||.|.|
Frog   242 NMDREAREEYLVVIQAKDMGGHMGGLSGTTTVTVTLTDVNDNPPKF------------------- 287

  Fly  1107 MEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKSRRRMVRALT 1171
                                                                 |.|:.:
Frog   288 -----------------------------------------------------AMSQYQ------ 293

  Fly  1172 TKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYEL---QGEQV-------ERTPGMPMLRVH 1226
                 |.:.||..:|..|.::.|:|.|.|.||...:::   .|:.|       :...|:..||
Frog   294 -----FVVPEDVGIGDTVGRVKANDRDTGDNAKSSFDIIDGDGKDVFEMTTDPQTQDGLIRLR-- 351

  Fly  1227 GVKYFAIDKLSGELSVNYPL---SANIEIMLNLTVTDIDGL--KDSTCLRFTVMDVNNHAPTFKK 1286
                   ..|..|...:|.|   :||:    |:....|.|:  ||:..::.||.|. :..|.|..
Frog   352 -------KPLDFESKKSYILKVEAANV----NIDPRFISGVPFKDTATVKITVEDA-DEPPVFSS 404

  Fly  1287 SWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHL----PFTIKPASGVLKIGGQLDR 1347
            ..|..:..|....:.|:||::|.|.| ...:.|.::: |.|.    .|.|....|.:.:..:|||
Frog   405 PTYLLEVHENAVINGVIGQVSARDPD-SSASPIRFSI-DRHTDLDHQFNINADDGKITLAMELDR 467

  Fly  1348 ELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLML 1412
            |....::..|:||:.....|  .|.|.|.:.|||:|||.|||               ..|
Frog   468 ETNMWHNITVVATETRNHSQ--ISRVPVAIKVLDVNDNAPEF---------------ATD----- 510

  Fly  1413 PVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQI-DSRDGTISTISRI 1476
              |:|:|..:.:||..::.::|||||:..||: ..:||:.......|.|.| :::|.::|.::|.
Frog   511 --YEAFLCENGKPGQIIQTVSAIDKDDPRNGH-FFIYSLLPDMANNPNFTIKNNQDNSLSVLARH 572

  Fly  1477 NGYN--DYEHLNVSVIASDVGSPALSATAIVIVNLQG 1511
            ||:|  ..|...:.:|.||.|:|.||:|:.:.:.:.|
Frog   573 NGFNRLKQEVYFLPIIISDNGNPPLSSTSTLTIRVCG 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637
		Cadherin_repeat	325..407	CDD:206637
		Cadherin_repeat	416..524	CDD:206637
		Cadherin_repeat	534..626	CDD:206637
		Cadherin_repeat	641..>714	CDD:206637
		CA	851..925	CDD:214520	26/81 (32%)
		CA	1026..1085	CDD:214520	22/62 (35%)
		Cadherin_repeat	1177..1280	CDD:206637	30/117 (26%)
		Cadherin_repeat	1289..1385	CDD:206637	29/99 (29%)
		Cadherin_repeat	1414..1510	CDD:206637	32/98 (33%)
		CA	1576..1658	CDD:214520
		Cadherin_repeat	1666..1760	CDD:206637
cdh8	XP_002935098.2	CA	98..176	CDD:214520	26/82 (32%)
		Cadherin_repeat	182..>262	CDD:206637	26/138 (19%)
		Cadherin_repeat	291..398	CDD:206637	30/131 (23%)
		Cadherin_repeat	406..503	CDD:206637	29/100 (29%)
		Cadherin_repeat	511..613	CDD:206637	33/100 (33%)
		Cadherin_C	656..801	CDD:366437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11590
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000