Protein Alignment Der-2 and RHBDD2

DIOPT Version :10

• Sequence 1: NP_650553.1
• Gene: Der-2 / 42005
• FlyBaseID: FBgn0038438
• Length: 261
• Species: Drosophila melanogaster
• Sequence 2: NP_001035546.1
• Gene: RHBDD2 / 57414
• HGNCID: 23082
• Length: 364
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 63/262 - (24%)
• Similarity: 104/262 - (39%)
• Gaps: 80/262 - (30%)

  Fly     5 RQFYLEIPVVTRAYTTVCVLTTLAVH----LDLVSPLQLYFNP-TLIVRKFQIWRLATTFLYFGT 64
            |.|.|:.|:.....|    |.:.|:.    ..||:.:.:|.|| :|:.....|||.|..|  ..|
Human    35 RLFLLQQPLAPSGLT----LKSEALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNF--ERT 93

  Fly    65 IGISFFFNMVFTYRYCRMLEDGSFRGRSSDFVMMF-IFGGVLMTFFGIFVNLLFLGQ-------- 120
            :|         |.|:|             .|.::| ||..::...|....:|..||:
Human    94 VG---------TVRHC-------------FFTVIFAIFSAIIFLSFEAVSSLSKLGEVEDARGFT 136

  Fly   121 --AFTLM-LVYVWSR-RNPLVPMNFFGVLNFQAPYLPWVLLCCSMILGNTVWV-DVIGMGVGHIY 180
              ||.:: :..|.|| |..||    ||:: ..:..:||:||..|.::..|.:: :|.|:.:|..|
Human   137 PVAFAMLGVTTVRSRMRRALV----FGMV-VPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAY 196

  Fly   181 YV---------------LEDVYPTLSNGYRLIKTPYFLKRLFNEHIERNFQAAAEDR-----PGG 225
            .:               |:..:|     :.|::.....|.:.....||.   ||:.|     ||.
Human   197 GLTYCYSIDLSERVALKLDQTFP-----FSLMRRISVFKYVSGSSAERR---AAQSRKLNPVPGS 253

  Fly   226 FP 227
            :|
Human   254 YP 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Der-2	NP_650553.1	DER1	11..201	CDD:427988	51/223 (23%)
RHBDD2	NP_001035546.1	Rhomboid	54..204	CDD:426384	45/178 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..282		5/14 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..364