DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Der-2 and DERL2

DIOPT Version :9

Sequence 1:	NP_650553.1	Gene:	Der-2 / 42005	FlyBaseID:	FBgn0038438	Length:	261	Species:	Drosophila melanogaster
Sequence 2:	NP_057125.2	Gene:	DERL2 / 51009	HGNCID:	17943	Length:	239	Species:	Homo sapiens

Alignment Length:	234	Identity:	151/234 - (64%)
Similarity:	188/234 - (80%)	Gaps:	2/234 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALRQFYLEIPVVTRAYTTVCVLTTLAVHLDLVSPLQLYFNPTLIVRKFQIWRLATTFLYFGTIGI 67
            :||..||:||.|:|||||.|||||.||.|:|::|.||||||.||.:.||||||.|.||:||.:|.
Human     5 SLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLFFGPVGF 69

  Fly    68 SFFFNMVFTYRYCRMLEDGSFRGRSSDFVMMFIFGGVLMTFFGIFVNLLFLGQAFTLMLVYVWSR 132
            :|.|||:|.||||||||:||||||::|||.||:|||.|||.||:||:|:|||||||:||||||||
Human    70 NFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFLGQAFTIMLVYVWSR 134

  Fly   133 RNPLVPMNFFGVLNFQAPYLPWVLLCCSMILGNTVWVDVIGMGVGHIYYVLEDVYPTLSNGYRLI 197
            |||.|.|||||:||||||:|||||:..|::|||::.||::|:.|||||:.||||:|....|.|::
Human   135 RNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGHIYFFLEDVFPNQPGGIRIL 199

  Fly   198 KTPYFLKRLFNEHIE-RNFQAAAEDRPGGFPWGGEGQPL 235
            |||..||.:|:...| .|:....|:|||||.| ||||.|
Human   200 KTPSILKAIFDTPDEDPNYNPLPEERPGGFAW-GEGQRL 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Der-2	NP_650553.1	DER1	11..201	CDD:282380	129/189 (68%)
DERL2	NP_057125.2	DER1	13..203	CDD:398288	129/189 (68%)
DERL2	NP_057125.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..239		13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154213
Domainoid	1	1.000	290	1.000	Domainoid score	I1562
eggNOG	1	0.900	-	-		E1_COG5291
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9356
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2515
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54051
OrthoDB	1	1.010	-	-		D1609512at2759
OrthoFinder	1	1.000	-	-		FOG0000789
OrthoInspector	1	1.000	-	-		otm41327
orthoMCL	1	0.900	-	-		OOG6_101672
Panther	1	1.100	-	-	LDO	PTHR11009
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2482
SonicParanoid	1	1.000	-	-		X1827
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800