Protein Alignment Gyc89Db and Gucy1a2

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_076446.1
• Gene: Gucy1a2 / 66012
• RGDID: 621655
• Length: 730
• Species: Rattus norvegicus
• Alignment Length: 600
• Identity: 145/600 - (24%)
• Similarity: 267/600 - (44%)
• Gaps: 131/600 - (21%)

  Fly    64 FCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK---MKSPSMQLTNMD 125
            |...||..||..      .::::|:.|....||....|.:...:|.::.|   ::|||.....:.
  Rat   171 FGEEFFKICFDE------NERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELP 229

  Fly   126 DDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGP-------IKLTE 183
            :....:.|......:...::|.:....|..|.|::....:|::. .|...:.|       ..:.|
  Rat   230 EGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEK-FCSDGSTPSNYSCLTFLIKE 293

  Fly   184 GPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPS---VDLNVFLELFPFTIVLDHDMKITLAG 245
            ...|.|.|               |:....||:  |:   :.:|.|...|||.::.|.:|.:...|
  Rat   294 CETTQITK---------------NIPQGTSQI--PTDLRISINTFCRTFPFHLMFDPNMVVLQLG 341

  Fly   246 EKIVETWILHNPGVNPKTFIGSHILERFK-CRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAA 309
            |           |:..:....:|.:.:|: |                      ||::....| |.
  Rat   342 E-----------GLRKQLRCDNHKVLKFEDC----------------------FEIVSPKVN-AT 372

  Fly   310 YDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLR 374
            :|..|                    |..:..|......|  |:...::|::
  Rat   373 FDRVL--------------------LRLSTPFVIRTKPE--ASGTDNEDKV-------------- 401

  Fly   375 SILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMF 439
             :.:||||.::.:.::::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...
  Rat   402 -MEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGL 463

  Fly   440 EKEEQRSDE----LEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEV 500
            :|   |.|:    |||:.:..:..|::..:||||:.|..:|:::.:.::...:.|::|:::|.::
  Rat   464 KK---RMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDI 525

  Fly   501 MNIYDSGSNNI---QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAE 562
            :     |...|   ...||.::.||::::..|.:.....:|||||:|..|...||....:..||:
  Rat   526 V-----GFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAK 585

  Fly   563 HACDLALRVMKKVKAHALPG---VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSD 624
            ....:||::|:..:....|.   :.:|:||:||.|:|||||:::|||||||:.|..||:.||.|.
  Rat   586 PIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSH 650

  Fly   625 PWMIQLS--NYTALK 637
            |..|.:|  .|..||
  Rat   651 PRRINISPTTYQLLK 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	20/99 (20%)
		HNOBA	218..479	CDD:462234	60/268 (22%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	54/157 (34%)
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:462233	20/102 (20%)
		HNOBA	314..501	CDD:462234	58/262 (22%)
		Guanylate_cyc	512..696	CDD:425528	54/158 (34%)