DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	145/600 - (24%)
Similarity:	267/600 - (44%)	Gaps:	131/600 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK---MKSPSMQLTNMD 125
            |...||..||..      .::::|:.|....||....|.:...:|.::.|   ::|||.....:.
  Rat   171 FGEEFFKICFDE------NERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELP 229

  Fly   126 DDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGP-------IKLTE 183
            :....:.|......:...::|.:....|..|.|::....:|::. .|...:.|       ..:.|
  Rat   230 EGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEK-FCSDGSTPSNYSCLTFLIKE 293

  Fly   184 GPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPS---VDLNVFLELFPFTIVLDHDMKITLAG 245
            ...|.|.|               |:....||:  |:   :.:|.|...|||.::.|.:|.:...|
  Rat   294 CETTQITK---------------NIPQGTSQI--PTDLRISINTFCRTFPFHLMFDPNMVVLQLG 341

  Fly   246 EKIVETWILHNPGVNPKTFIGSHILERFK-CRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAA 309
            |           |:..:....:|.:.:|: |                      ||::....| |.
  Rat   342 E-----------GLRKQLRCDNHKVLKFEDC----------------------FEIVSPKVN-AT 372

  Fly   310 YDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLR 374
            :|..|                    |..:..|......|  |:...::|::
  Rat   373 FDRVL--------------------LRLSTPFVIRTKPE--ASGTDNEDKV-------------- 401

  Fly   375 SILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMF 439
             :.:||||.::.:.::::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...
  Rat   402 -MEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGL 463

  Fly   440 EKEEQRSDE----LEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEV 500
            :|   |.|:    |||:.:..:..|::..:||||:.|..:|:::.:.::...:.|::|:::|.::
  Rat   464 KK---RMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDI 525

  Fly   501 MNIYDSGSNNI---QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAE 562
            :     |...|   ...||.::.||::::..|.:.....:|||||:|..|...||....:..||:
  Rat   526 V-----GFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAK 585

  Fly   563 HACDLALRVMKKVKAHALPG---VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSD 624
            ....:||::|:..:....|.   :.:|:||:||.|:|||||:::|||||||:.|..||:.||.|.
  Rat   586 PIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSH 650

  Fly   625 PWMIQLS--NYTALK 637
            |..|.:|  .|..||
  Rat   651 PRRINISPTTYQLLK 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	20/99 (20%)
		HNOBA	218..479	CDD:400168	60/268 (22%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	54/157 (34%)
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002	20/102 (20%)
		HNOBA	314..501	CDD:285003	58/262 (22%)
		CYCc	483..672	CDD:214485	61/187 (33%)
		Guanylate_cyc	512..696	CDD:278633	54/158 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820