DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and gucy2ca

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	352	Identity:	104/352 - (29%)
Similarity:	163/352 - (46%)	Gaps:	65/352 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 LRSILLKGQMFYIKDVDSLIFL---------CSPLIENL---DELHGIGLYLNDLNPHGLSRE-- 423
            :..|..||.::....:...|.|         ||.:.|.|   ....|..::..||:..|:...
Zfish   602 VEGISQKGDVYSFAIISQEIILRKSPFHTSCCSDMAEKLYLVQYPRGPNVFRPDLSFEGVGETEA 666

  Fly   424 ----LVMAGWQ---------------------------HCSKLEIMFEKEEQRSDELEKSLE--- 454
                |:.:.|:                           :.|.::.:..:.:..|..||..:|
Zfish   667 ELFVLIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYMDNLIRRLQMYSRNLEHLVEERT 731

  Fly   455 -LADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNI---QDAM 515
             |..:.:.:.|:|.:.::|.|:...::::.....:.::||::.|.:::     |...|   ...|
Zfish   732 ALYKAERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVTIYFSDIV-----GFTTICHHSTPM 791

  Fly   516 QAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRV---MKKVK 576
            :.|..||.::...|..:....||||||:|..||..||.|..| ..||...|.:||.:   |...:
Zfish   792 EVVDMLNDIYKNFDSILDHHDVYKVETIGDAYMVASGLPRCNGNRHAVDICLMALDILEFMGTFQ 856

  Fly   577 AHALPGVA--IRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQ 639
            ...|||:.  ||:||:|||..|||||.|:||||||||||||||||||:..|..|.:|..|...:|
Zfish   857 LRHLPGIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTGLPLRIHVSESTIKILQ 921

  Fly   640 KVG--YKVEARGFVKVKGKGEMETYWL 664
            :..  ::.|.||...:||||:..||||
Zfish   922 RTDCEFECERRGETFLKGKGKEMTYWL 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	25/154 (16%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	79/188 (42%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141
		PKc_like	428..698	CDD:304357	15/95 (16%)
		Pkinase_Tyr	451..689	CDD:285015	15/86 (17%)
		CYCc	736..929	CDD:214485	72/197 (37%)
		Guanylate_cyc	763..950	CDD:278633	79/191 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910