DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and adcy1b

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	303	Identity:	87/303 - (28%)
Similarity:	140/303 - (46%)	Gaps:	53/303 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 LYLNDLNPHGLSRELVMAGWQHCS--------KLEIMFEKEEQRSDELEKSLELADSWKRQGDE- 465
            ||:..|...|..|   .:||...|        .|.:........|.:|:..|.|...|..|.:|
Zfish   741 LYITILELSGFRR---ASGWALLSVRGLEPLLSLLLFSTAVALHSRQLDLKLRLDFLWATQAEEE 802

  Fly   466 -------------LLYSMIPRPIAERMRKSE----EHVCQSFEEVSVIFIEVMNIYD----SGSN 509
                         :|::::|..:|:....|.    :...||:.:|.|:|..:.|..|    ...|
Zfish   803 RDGMEKVKLDNKRILFNLLPVHVAQHFLLSNPRNMDLYYQSYAQVGVLFASIPNFNDFYIELDGN 867

  Fly   510 NIQDAMQAVTTLNKVFSALDEEIISPFVY----KVETVGMVYMAVSG--------APDVNPLHAE 562
            |:  .::.:..||::.:..| |::....|    |::|:|..||:..|        |......|..
Zfish   868 NM--GVECLRLLNEIIADFD-ELMDKECYKDIEKIKTIGSTYMSAVGLVPTIGTKAKKSTATHLS 929

  Fly   563 HACDLALR---VMKKVKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSD 624
            ...|.|:.   |:.::...:.....:|||||.|||||||:|.:.|:|.::|:|||.||||:|:..
Zfish   930 TIADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGV 994

  Fly   625 PWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWLLEG 667
            |..||::. ...::.:..|.:..||.|.|||||:|.||: |||
Zfish   995 PGKIQVTE-DVYRLLQNNYDLMCRGNVSVKGKGQMLTYF-LEG 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	19/90 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	64/195 (33%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831
		CYCc	236..431	CDD:214485
		Guanylate_cyc	272..454	CDD:278633
		DUF1053	498..585	CDD:283888
		CYCc	806..1012	CDD:214485	56/209 (27%)
		Guanylate_cyc	839..1035	CDD:278633	65/200 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900