DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and adcy2a

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_692173.5	Gene:	adcy2a / 563724	ZFINID:	ZDB-GENE-061109-1	Length:	1155	Species:	Danio rerio

Alignment Length:	291	Identity:	80/291 - (27%)
Similarity:	152/291 - (52%)	Gaps:	36/291 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 LIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQ 462
            ::::|..:..:.|::..:....|:|:.     ::..:|:.:::      ::.:|..|..::.:..
Zfish   862 VLKDLKTMGSVSLFIFFITLLVLARQN-----EYYCRLDFLWK------NKFKKECEEIETMENL 915

  Fly   463 GDELLYSMIPRPIAE----RMRKSEEHVCQSFEEVSVIFIEV---MNIYDSGSNNIQDAMQAVTT 520
            ...||.:::|..:||    |..|:|:...||::.|.|:|..:   ...|.....| ::.::.:..
Zfish   916 NRVLLENVLPAHVAEHFLARNWKNEDLYHQSYDLVCVMFASIPDFKEFYTESDVN-KEGLECLRL 979

  Fly   521 LNKVFSALDEEIISP---FVYKVETVGMVYMAVSG-----AP------DVNPLHAEHACDLALRV 571
            ||::.:..||.:..|   .|.|::|:|..|||.:|     .|      |...:|.....:.|..:
Zfish   980 LNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGPEYTQEHDRQYMHIGTMVEFAFAL 1044

  Fly   572 MKK---VKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNY 633
            :.|   :..|:.....:|||||.|||.|||:|.:.|:|.::|:|||.||||:|:.....||::..
Zfish  1045 VGKLDVINKHSFNDFKLRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEE 1109

  Fly   634 TALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            |:..:|.:||....||.:.||||||::||::
Zfish  1110 TSCILQTLGYTCSCRGIINVKGKGELKTYFV 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	12/84 (14%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	65/197 (33%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831
		CYCc	295..498	CDD:214485
		Guanylate_cyc	340..524	CDD:278633
		DUF1053	554..658	CDD:283888
		CYCc	912..1120	CDD:214485	62/208 (30%)
		Guanylate_cyc	942..1141	CDD:278633	65/200 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810