DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and adcy6b

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_002666536.2	Gene:	adcy6b / 560807	ZFINID:	ZDB-GENE-090127-2	Length:	1174	Species:	Danio rerio

Alignment Length:	860	Identity:	202/860 - (23%)
Similarity:	330/860 - (38%)	Gaps:	274/860 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VDCKHQSFKTHQIYPDK------LMPD---FAAALSASTGESFDFCMNFFGRCFVRFFSNFGYDK 84
            ::.|.:....|:||..|      |..|   |.:..|..|.:.....:|   ..|.||      ||
Zfish   366 INAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLN---ELFARF------DK 421

  Fly    85 M--------IRSTGR-YFCDFLQSI-----DNIH--VQMRFTYPKMKSPSMQLTNMDDDGAVILY 133
            :        |:..|. |:|  :..:     |:.|  |:|.....:..|...::|.::.:..|.::
Zfish   422 LAWENHCLRIKILGDCYYC--VSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIH 484

  Fly   134 RSGRT-----GMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYR 193
             |||.     |:.|:..        :.:..|:|   |.:|.: .||.||.|.:|        |..
Zfish   485 -SGRVHCGVLGLRKWQF--------DVWSNDVT---LANQME-AGGKAGRIHIT--------KAT 528

  Fly   194 LDFDNRDY-------------------------------------MAKRVNVIAHPSQLKMP--- 218
            |.:.|.||                                     |||.....|:.|:..||
Zfish   529 LQYLNGDYEVEAGFGGDRNAYLNNNNIETFFVLGCSQKRKEEKAMMAKMQRARANSSEGLMPRWV 593

  Fly   219 -------SVDLNVFLE-----------------LFPFTIV-----------------LDHDMKIT 242
                   :.|..||.:                 |.|...|                 .||..|..
Zfish   594 PDRSFSRTKDSKVFRQMGIDEASSKDNRCAQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFL 658

  Fly   243 LA------------------GEKIVETWIL-------------HNP---GVNPKTF-IGSHIL-- 270
            |.                  |..:..|.::             |.|   |:....| |.:|:|
Zfish   659 LTFQTPLLEKKYSKKVDDRFGGYVACTLLVFCFIVFIQIVIFPHTPLMLGLFITIFIILAHVLFI 723

  Fly   271 -ERFKCRR--PKDTQIQWETILQMR---------TVLFEFELIRTGHNRAAYDAALN-FDFENFD 322
             ..:.|.:  |...|...:.|:|.|         |:|..|           ..|.:| |..:..|
Zfish   724 CAIYSCVKLFPVTLQTVSKRIVQSRINSTLVGVFTILLLF-----------ISAFVNMFTCDRTD 777

  Fly   323 ----EASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMF 383
                .|..||.::::.|...  ::.....|:.......:....|......:|| |.::|......
Zfish   778 MLACVAGHLNISESVTLCLL--YNLSGLAEDPFFLCLDQPSACPLPEYFTYSV-LLTLLCCSVFL 839

  Fly   384 YIKDVDSLIF-----LC---------SPLIENLDELHGI-GLY-LNDLN---------------P 417
            :|..:..|:.     :|         ..|::|.|.|..: .|| .|:.|               |
Zfish   840 HISSIGKLVLMLFIQICFLLLIEWPLVSLLDNADLLDTVDALYAFNETNYCQETVTKVSLRVSIP 904

  Fly   418 HGLSRELVMAGWQHCSKLE----IMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIA-- 476
            ..|: ..|:|.:.|..::|    :.|..:.|.::|.|:..|| .::.|:   ||::::|:.:|
Zfish   905 VILT-VFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL-QAYNRR---LLHNILPKDVAAH 964

  Fly   477 --ERMRKSEEHVCQSFEEVSVIFIEVMNI----YDSGSNNIQDAMQAVTTLNKVFSALDEEIISP 535
              .|.|:::|...||.|.|:|:|..:.|.    .:..:||  :.::.:..||::.:..| ||||.
Zfish   965 FLARERRNDELYYQSCECVAVMFASISNFSEFYTELEANN--EGVECLRLLNEIIADFD-EIISE 1026

  Fly   536 FVY----KVETVGMVYMAVSGAPD-----VNPLHAEHACDLALRV---MKKVKAHALPGVAIRVG 588
            ..|    |::|:|..|||.||..|     ....|.....|.|:|:   ||.:..|:.....:::|
Zfish  1027 EKYKQLEKIKTIGSTYMAASGLNDSTYDKEGRTHILALADYAMRLREQMKYINEHSFNNFQMKIG 1091

  Fly   589 INSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKV 653
            :|.|||||||:|.:.|:|.::|:|||.||||:|:..|..||::......::..||::|.||.|||
Zfish  1092 LNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLESKGYQLECRGLVKV 1156

  Fly   654 KGKGEMETYWLLEGP 668
            ||||:|.||:|..||
Zfish  1157 KGKGDMTTYFLNSGP 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	33/161 (20%)
		HNOBA	218..479	CDD:400168	71/397 (18%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	72/192 (38%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454	1/9 (11%)
		Guanylate_cyc	378..562	CDD:306677	45/215 (21%)
		DUF1053	590..677	CDD:310728	11/86 (13%)
		Guanylate_cyc	975..1169	CDD:306677	73/196 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900