DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and si:dkey-206f10.1

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_009293230.1	Gene:	si:dkey-206f10.1 / 560719	ZFINID:	ZDB-GENE-041014-154	Length:	1187	Species:	Danio rerio

Alignment Length:	464	Identity:	118/464 - (25%)
Similarity:	207/464 - (44%)	Gaps:	108/464 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 HNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFE 319
            |:|||          |::|.|...::..::  .:|.:..:                  |:||...
Zfish   717 HSPGV----------LQQFCCWIHENNSMR--NLLTITAI------------------AMNFGMA 751

  Fly   320 NFD----EASSLNEAQAMALASAKEFSAENAKEEAAAAATSKD--EIDPATGQRRHSVGLR-SIL 377
            .||    .:|.:.|      .|.:|.....|.::...|.|..:  .:.........:|.|| |.|
Zfish   752 LFDMMWCNSSEMKE------ISTRETEGYKAGQKPLTACTYPEVFVLSGVVSMVTCAVFLRMSSL 810

  Fly   378 LKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRE----------LVMA----- 427
            ||        :..|:|:.: :.....|:....||::......|||.          |:||
Zfish   811 LK--------LTILLFVVA-VYTYFIEVSFHMLYVHQQEHEHLSRSHFLRRKGVSILLMAMFMIA 866

  Fly   428 ------GWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDE-LLYSMIPRPIA----ERMRK 481
                  .|:..::|:.::..:.|:  |:::..:|     |:.:| ||::::|..:|    ||.|.
Zfish   867 VLYNGRRWEATTRLDFLWRLQAQQ--EVQEMRDL-----REHNECLLHNILPAHVARHFLERNRN 924

  Fly   482 SEEHVCQSFEEVSVIFIEV--MNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPF---VYKVE 541
            .:|...||::||.|:|..:  .|.|........:.::.:..||::.:..||.:...:   :.|::
Zfish   925 DQELYSQSYDEVGVMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIADFDELLEESYFLDIEKIK 989

  Fly   542 TVGMVYMAVSG-APD-----VNPLHAEHACDLAL------RVMKKVKAHALPGVAIRVGINSGPV 594
            |:|..|||.|| :||     ||..|  |..:|.|      ..::::..|::....:||||..|||
Zfish   990 TIGSCYMAASGLSPDKQSRVVNDWH--HLSELVLFALAMQETLREINKHSMNNFQLRVGIAHGPV 1052

  Fly   595 VAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKG---- 655
            ||||:|...|:|.::|.|||.||||:|:.....||:...|...:...|:.:|.||.:.:||
Zfish  1053 VAGVIGATKPQYDIWGMTVNLASRMDSTGVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSER 1117

  Fly   656 KGEMETYWL 664
            ||.:.||::
Zfish  1118 KGRVRTYFI 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	50/256 (20%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	65/198 (33%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:292831
		CYCc	343..538	CDD:214485
		Guanylate_cyc	382..564	CDD:278633
		DUF1053	<611..661	CDD:283888
		CYCc	899..1097	CDD:214485	65/199 (33%)
		Guanylate_cyc	928..1126	CDD:278633	65/199 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810