DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and Adcy4

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_062158.2	Gene:	Adcy4 / 54223	RGDID:	2034	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	263	Identity:	82/263 - (31%)
Similarity:	143/263 - (54%)	Gaps:	39/263 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 QHCSKLEIMFEK----EEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERM----RKSEEHV 486
            ::..:|:.:::|    |.:.::.:|....|          ||.:::|..:|.:.    |::|:..
  Rat   808 EYYCRLDFLWKKKLRQEREETETMENLTRL----------LLENVLPAHVAPQFIGQNRRNEDLY 862

  Fly   487 CQSFEEVSVIFIEVMNI--YDSGSNNIQDAMQAVTTLNKVFSALDEEIISP---FVYKVETVGMV 546
            .||:|.|.|:|..:.:.  :.|.||...:.::.:..||::.:..||.:..|   .|.|::|:|..
  Rat   863 HQSYECVCVLFASIPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGST 927

  Fly   547 YMAVSGAPDVNP-----LHAEHAC-------DLALRVMKK---VKAHALPGVAIRVGINSGPVVA 596
            |||.:|. :..|     ..||.:|       :.|:.:..|   :..|:.....:|||:|.|||||
  Rat   928 YMAATGL-NATPGQDTQQDAERSCSHLGTMVEFAVALGSKLGVINKHSFNNFRLRVGLNHGPVVA 991

  Fly   597 GVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMET 661
            ||:|.:.|:|.::|:|||.||||||:.....||::..||..:|.:||...:||.:||||||::.|
  Rat   992 GVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGVIKVKGKGQLCT 1056

  Fly   662 YWL 664
            |:|
  Rat  1057 YFL 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	9/52 (17%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	71/197 (36%)
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831
		CYCc	219..422	CDD:214485
		Guanylate_cyc	264..430	CDD:278633
		DUF1053	479..580	CDD:283888
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..523
		CYCc	824..1039	CDD:214485	68/225 (30%)
		Guanylate_cyc	861..1060	CDD:278633	71/200 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810