DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	691	Identity:	199/691 - (28%)
Similarity:	319/691 - (46%)	Gaps:	113/691 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYIQQEYGMETW---RKVCQIVDCKHQSFKTHQIYPDKLMPDFAAA----LSAST 58
            |||.:..:::..:.:.||.|.|   :|..|:.:  ...|....||.|....|..||    |:.:.
Mouse     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDE--EGQFLVRIIYDDSKTYDLVAAASKVLNLNA 63

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTN 123
            ||    .:..||:.|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:
Mouse    64 GE----ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTD 124

  Fly   124 MD-DDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLT 187
            .: ..|.::.|.|.|.|:...:||.:..||::.:|.::...|::.:|:.|..|...|:..|....
Mouse   125 AEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEE 189

  Fly   188 VIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETW 252
            ...:....|:.......|::..              .|.:.|||.|:.|.::.:|..|..|....
Mouse   190 DFYEDLDRFEENGTQESRISPY--------------TFCKAFPFHIIFDRNLVVTQCGNAIYRVL 240

  Fly   253 ILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFD 317
            ....||               .|                 ::|..|.|:|. |        ::..
Mouse   241 PQLQPG---------------NC-----------------SLLSVFSLVRP-H--------IDIS 264

  Fly   318 FENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQM 382
            |...     |:....:.:..:||...:..|.|.      :||:   ||..     :..:.|||||
Mouse   265 FHGI-----LSHINTVFVLRSKEGLLDVEKLEC------EDEL---TGAE-----ISCLRLKGQM 310

  Fly   383 FYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIMFEK 441
            .|:.:.||::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:
Mouse   311 IYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL--- 372

  Fly   442 EEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVM--NIY 504
                :|.|:.:|...:..|::.|.||||::|..:|..:|.......:.::.|:::|..::  |.:
Mouse   373 ----TDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAF 433

  Fly   505 DSGSNNIQDAMQAVTTLNKV---FSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACD 566
            .|...:.:.||:.|..||.:   |..|.:...:||||||||||..||.|||.|:....||...|.
Mouse   434 CSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICH 498

  Fly   567 LALRVMKKVKAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQ 629
            |||.:|:......:.|  |.|.:||::|.||.||:|.::|||||||:|||..||.|::.:...|.
Mouse   499 LALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKIN 563

  Fly   630 LSNYTALKVQKVG-----YKVEARGFVKVKGKGEMETYWLL 665
            :|.||...:....     :.:|.||.|.:|||.|....|.|
Mouse   564 VSEYTYRCLMSPENSDPLFHLEHRGPVSMKGKKEPMQVWFL 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	48/166 (29%)
		HNOBA	218..479	CDD:400168	69/266 (26%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	71/188 (38%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572	48/169 (28%)
		HNOBA	207..406	CDD:311573	70/279 (25%)
		Guanylate_cyc	412..605	CDD:306677	72/193 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820