DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and ACXB

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	147/697 - (21%)
Similarity:	243/697 - (34%)	Gaps:	236/697 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SGRT----GMSKYLIGQMTEVAKE---FYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKY 192
            ||||    .:::|.:...||||:.   .....||.|:|         ||.|.:.:...:..:..|
  Fly   445 SGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLL---------TAAPSRNSVRSVDAVHSY 500

  Fly   193 RLDFDNRDYMAKRVNVIAHPSQL---------KMPSVDLNVFLELFPFTIVLDHDMKITLAGEKI 248
             .:.|.....|.|.:.|..|:.:         |||....|:   ..|......:|.|:
  Fly   501 -AEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGFNI---RSPCCRDNSNDEKV------- 554

  Fly   249 VETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRA-AYDA 312
                              :|.|..| |...||:.::|..:.:...:|....|:..|.... .|..
  Fly   555 ------------------NHGLGMF-CVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQ 600

  Fly   313 ALN-----------FDFENFDEASSL----------------NEAQAMALASAKEFSAENAKEEA 350
            .:|           .|...|...:||                |:::.....|.|.|....
  Fly   601 IVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWE----- 660

  Fly   351 AAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLD----ELHGIG-- 409
                           :.:||..||..:      |:..|.|...|.|.::.|.|    ||..|.
  Fly   661 ---------------RIQHSFVLRVTI------YMSIVASYYLLISTILLNCDKNQYELDVINSK 704

  Fly   410 LYLNDL------NPH----------GLS--------------------RELVMAGWQH------- 431
            ||..|:      ||.          |:|                    ..||:..:|:
  Fly   705 LYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHS 769

  Fly   432 -----------------CSKLEIMFEKEEQR----------SDELEKSLELADSWKRQGDELLYS 469
                             |..|..|:.||.|.          :.:|:...:.||...:....||.:
  Fly   770 ATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTN 834

  Fly   470 MIPRPIAERMRKS---EEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEE 531
            ::|..:.|....|   .|...::::.|||:|..::| :.....:::.....:|..:::.:|..|.
  Fly   835 ILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLIN-FQMDLPSLRVLNDIITEFDRLLNAYKEY 898

  Fly   532 IISPFVYKVETVGMVYMAVSGAPDV-------NPLHAEHACDL---------------------- 567
            .:   |.|::.||..|||..|....       :..||.::.:|
  Fly   899 YV---VEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFI 960

  Fly   568 ----ALRVMKKV----KAH-------ALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTAS 617
                ||.:|:.:    ||:       ||....|.:||::|.::|||||...|.|.::|:.||.||
  Fly   961 MTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMAS 1025

  Fly   618 RMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            ||||:..|..|.::..||..:::.......||...|||:||:.||::
  Fly  1026 RMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFV 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	9/32 (28%)
		HNOBA	218..479	CDD:400168	62/364 (17%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	59/221 (27%)
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485	5/13 (38%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	13/47 (28%)
		CYCc	825..1047	CDD:214485	56/225 (25%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	59/222 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740