DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and NPR2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	358	Identity:	117/358 - (32%)
Similarity:	192/358 - (53%)	Gaps:	63/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 PATGQRR---HSVG--LRSILLKGQMFYIKDVDSLIFLCSP--LIENLDELHGIGLYLN-DLNPH 418
            |.||.::   :|.|  |:.|.|:...||::.:|     .||  :::.:  .:|...|.. .::..
Human   754 PTTGMQKADVYSFGIILQEIALRSGPFYLEGLD-----LSPKEIVQKV--RNGQRPYFRPSIDRT 811

  Fly   419 GLSRELVMAGWQHC---------------------------SKLEIMFEKEEQRSDELEKSLE-- 454
            .|:.|||:. .:.|                           |.|:.:..:.||.::.|||.:|
Human   812 QLNEELVLL-MERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEER 875

  Fly   455 ----LADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAM 515
                |.:  ||:.:.|||.::|..:||::::.|....::|:.|::.|.:::......:.:  ..|
Human   876 TQAYLEE--KRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES--TPM 936

  Fly   516 QAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKVKAHA 579
            |.||.||.:::..|..|.:..||||||:|..||.|||.|..| ..||.....:||.::..|.:..
Human   937 QVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFR 1001

  Fly   580 L-----PGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQ 639
            :     ..:.:|:|:::|||.|||||:|:||||||||||||||||||:.....|.:|:.|...:.
Human  1002 IRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALD 1066

  Fly   640 KVG-YKVEARGFVKVKGKGEMETYWLL---EGP 668
            ::| :::|.||.|::||||:|.|||||   :||
Human  1067 ELGCFQLELRGDVEMKGKGKMRTYWLLGERKGP 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	37/157 (24%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	75/183 (41%)
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556
		PK_GC-A_B	521..848	CDD:270944	20/101 (20%)
		HNOBA	<857..902	CDD:311573	15/46 (33%)
		CYCc	881..1065	CDD:214485	71/187 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810